ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

FDA approval for Diovan (Valsartan)

Novartis Pharmaceuticals Corporation announced today that the US Food and Drug Administration (FDA) approved Diovan (valsartan), the most prescribed ARB (angiotensin receptor blocker) in the US and worldwide, for a new indication to reduce cardiovascular death in patients at high risk (with left ventricular failure or left ventricular dysfunction) following a heart attack.

4 Aug 2005

Not enough women take part in heart drug trials

Scientists say because women are under-represented in the clinical trials of heart drugs, doctors are left in the dark as to how treatments may work differently in their bodies.

3 Aug 2005

Controlling high blood pressure in individuals age 80 years and older has become a major national health problem

The study found that almost three fourths of those 80 years and older have hypertension -- blood pressure greater than 140 systolic over greater than 90 diastolic. Fewer than 10 percent have "normal" blood pressure levels -- less than 120 systolic over less than 80 diastolic.

26 Jul 2005

GenoMed submits 50th provisional patent application

GenoMed announced today that the Company has submitted its 50th provisional patent application, a major milestone in any development stage company. GenoMed has so far been awarded two patents, one for treating acute kidney failure without dialysis, and another for hastening lung maturation in prematurely born infants.

26 Jul 2005

Eplerenone shows benefit for patients with damaged hearts

In the first thirty days following a heart attack, one in three deaths among patients with signs of heart failure may be preventable by early treatment with a drug called eplerenone (Inspra, Pfizer Ltd), according to new data published in the Journal of the American College of Cardiology (JACC).

26 Jul 2005

ACE inhibitors should be available at no cost to the 8 million Americans over age 65 who have diabetes

Nothing in life is free, the old saying goes. But maybe some things should be, according to a new University of Michigan Health System study.

18 Jul 2005

Study compares four standard measures for heart failure treatment

UCLA investigators found large gaps and marked variation in U.S. hospitals' heart failure treatment based on adherence to four standard quality measures. The study points to the need for hospitals to establish education programs and systems to improve quality of care for this patient population.

11 Jul 2005

Major study says for diabetics with high blood pressure diuretics are the best option

A major new study has found that for people with type 2 diabetes and high blood pressure, cheaper diuretic medications may be the most cost-effective option in reducing hypertension.

29 Jun 2005

Diuretics work better than newer and more costly medicines for diabetics with high blood pressure

Diuretics (water pills) work better than newer and more costly medicines in the treatment of high blood pressure and prevention of some forms of heart disease in people with type 2 diabetes, according to results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

28 Jun 2005

National Service Framework for chronic heart failure is urgently needed

A new National Service Framework for chronic heart failure is urgently needed, because patients with heart failure are getting a raw deal, despite the availability of effective treatment, say leading cardiologists in Heart.

15 Jun 2005

Ruboxistaurin shows favorable effects on kidney damage and function in people with type 2 diabetes and nephropathy

Eli Lilly and Company today announced encouraging results from a one-year pilot study examining the effect of ruboxistaurin mesylate in persons with type 2 diabetes and kidney disease (also known as "diabetic nephropathy").

12 Jun 2005

Diabetes knowledge has little effect on improving outcomes

A new study by Duke Clinical Research Institute researchers finds little relationship between what a diabetic patient knows about the disease and control of its associated cardiovascular risk factors or how well the patient ultimately fares.

3 Jun 2005

Latest patterns of medication use in the U.S.

In 2004, 82 percent of adults and more than 50 percent of children took at least one prescription, over-the-counter (OTC), or herbal/natural medication in any given week, Boston University researchers revealed recently.

30 May 2005

Hormone Replacement Therapy (HRT) has a beneficial impact on cardiovascular health in hypertensive postmenopausal women

Oral Hormone Replacement Therapy (HRT) seems to have a beneficial impact on cardiovascular health in hypertensive postmenopausal women, researchers reported at the American Society of Hypertension Twentieth Annual Meeting held in San Francisco.

16 May 2005

Polypill improves survival rates for heart disease sufferers

A ‘polypill’ made up of a combination of drugs could extend the lives of thousands of patients with coronary heart disease, say researchers at The University of Nottingham.

10 May 2005

Heart failure patients do better when treated according to guidelines, but too many doctors still fail to prescribe the best treatments

Heart failure patients who are treated in accordance with established European guidelines do better than patients who are not, yet many doctors are still not adhering to the guidelines, according to pioneering research published in Europe’s leading cardiology journal, the European Heart Journal.

4 May 2005

Diuretics work better for high blood pressure

Study results by faculty members of the University of Texas School of Public Health at Houston suggests that the older, cheaper diuretics remain the drug of choice for both black and non-black patients in treating high blood pressure and reducing risk of heart disease, and confirms earlier findings that diuretics rather than newer, more expensive drugs such as ACE inhibitors, calcium channel blockers, or beta blockers should be preferred as a first therapy for most patients.

5 Apr 2005

Blood pressure control suggests new approach to hypertension therapy

The kidneys have long been known to play a major role in many cases of high blood pressure, but a new study by researchers at Duke University Medical Center reveals that the body's control of blood pressure depends as much on other organs in the body.

3 Apr 2005

Questions about validity of HOPE TOO vitamin E study

A study published in the March 16 issue of Journal of the American Medical Association (JAMA) suggesting that a "daily-dose" of vitamin E (400 international units) among high-risk (chronically ill) cardiovascular patient populations is associated with a greater risk of heart failure is being challenged by leading health researchers around the country who claim the study lacks the adequate research and controlled sampling audience to justify this conclusion.

16 Mar 2005

Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack

Although the type and intensity of treatment for acute myocardial infarction (AMI) [heart attack] varies widely across the country, elderly patients who receive intensive medical treatment may have comparable survival as those who undergo invasive cardiac procedures (such as angioplasty and bypass surgery), according to a study in the March 16 issue of JAMA.

15 Mar 2005

ACE Inhibitors News and Research

Further Reading

FDA approval for Diovan (Valsartan)

Not enough women take part in heart drug trials

Controlling high blood pressure in individuals age 80 years and older has become a major national health problem

GenoMed submits 50th provisional patent application

Eplerenone shows benefit for patients with damaged hearts

ACE inhibitors should be available at no cost to the 8 million Americans over age 65 who have diabetes

Study compares four standard measures for heart failure treatment

Major study says for diabetics with high blood pressure diuretics are the best option

Diuretics work better than newer and more costly medicines for diabetics with high blood pressure

National Service Framework for chronic heart failure is urgently needed

Ruboxistaurin shows favorable effects on kidney damage and function in people with type 2 diabetes and nephropathy

Diabetes knowledge has little effect on improving outcomes

Latest patterns of medication use in the U.S.

Hormone Replacement Therapy (HRT) has a beneficial impact on cardiovascular health in hypertensive postmenopausal women

Polypill improves survival rates for heart disease sufferers

Heart failure patients do better when treated according to guidelines, but too many doctors still fail to prescribe the best treatments

Diuretics work better for high blood pressure

Blood pressure control suggests new approach to hypertension therapy

Questions about validity of HOPE TOO vitamin E study

Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack

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