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Researchers identify compounds from Aspergillus that may be effective against SARS-CoV-2

Researchers from Ain Shams University have been exploring the use of compounds isolated from Aspergillus sp. against SARS-CoV-2.

13 May 2022

Development of a novel surface plasmon resonance-based assay to determine kinetics of SARS-CoV-2 spike – human ACE2 interaction

A team of scientists has recently studied the kinetic and thermodynamic characteristics of interaction between human ACE2 and spike receptor-binding domains of different variants of SARS-CoV-2.

13 May 2022

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

In a recent study posted to the bioRxiv* preprint server, researchers explored the role of the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein in SARS-CoV-2 fusion with the host membranes and coronavirus disease 2019 (COVID-19).

12 May 2022

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

In a recent study posted to the bioRxiv* preprint server, researchers assessed the selection effects in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Bayesian viral allele selection.

12 May 2022

Researchers identify cellular serpins as host factors that restrict SARS-CoV-2 infection

Researchers investigated differences in susceptibility between individuals and may have discovered a new opportunity for treatment.

12 May 2022

Delta- and Omicron BA.1-variant specificity of B cell repertoires established by an initial Wuhan strain infection

Researchers performed an unbiased evaluation of the early memory B cell repertoire specific for the Omicron and Delta variants of SARS-CoV-2.

12 May 2022

Imprinted antibody responses towards SARS-CoV-2 Omicron subvariants

A new study analyzed the imprinted antibody responses towards the SARS-CoV-2 Omicron subvariants.

12 May 2022

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

In a recent study published in the journal Vaccines, researchers revealed how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron evades neutralizing antibodies (nAbs).

12 May 2022

Antifungal agent Bifonazole as an antiviral against SARS-CoV-2

In a recent study published in the journal Molecular Therapy, researchers identified Bifonazole, an imidazole-based antifungal agent, to have potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using high-throughput screening of small molecules.

12 May 2022

Discovery of host co-factors necessary for SARS-CoV2 infection

A new study published in the journal EMBO Reports has reported on the shedding of two proteases, namely, ADAM10 and ADAM17, which aids in S protein-dependent molecular events.

11 May 2022

COVID-19-induced non-cell-autonomous anosmia

Researchers reported that SARS-CoV-2-induced anosmia was based on non-cell-independent processes.

11 May 2022

Decoy ACE2 nanoparticles block the entry of SARS-CoV-2 into cells

In a recent study posted to the bioRxiv* preprint server, researchers reported that nanoparticles could prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cell entry.

10 May 2022

Evasion of COVID-19 vaccine-medicated mucosal immunity by SARS-CoV-2 Omicron

Researchers depicted the evasion of the SARS-CoV-2 Omicron variant to mucosal immunity in SARS-CoV-2 vaccine recipients.

10 May 2022

Research highlight reports on the observed differences in transmissibility and pathogenicity of Omicron vs. earlier variants of SARS-CoV-2

A new paper published in Signal Transduction and Targeted Therapy reports the observed differences in transmissibility and pathogenicity of Omicron vs. earlier variants of SARS-CoV-2.

10 May 2022

mRNA boosters enhance neutralization of SARS-CoV-2 BA.1, BA.2 and BA.3

A study recently published in the journal Cell Host & Microbe has described that all three sublineages of the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibit similar host cell entry efficiency and are neutralized equally by antibodies generated in response to coronavirus disease 2019 (COVID-19) booster vaccination

10 May 2022

Deoxyribonucleic acid nanostructure sensor found to rapidly detect and inhibit SARS-CoV-2

Researchers reported on a three-layer designer deoxyribonucleic acid (DNA) nanostructure (DDN) strategy-based sensor designed by them for rapid and accurate SARS-CoV-2 detection and inhibition.

9 May 2022

Differences in COVID-19 outcomes related to sex

Researchers looked at gender variations in COVID-19 outcomes such as hospitalization, ICU admission, mortality, and heart damage.

9 May 2022

Study reveals immune responses to SARS-CoV-2 peptides in COVID-19 convalescent patients

A new study aimed to demonstrate the reactivity of COVID-19 serum obtained from patients in Tatarstan, Russia with S and N peptides that were previously identified as immunogenic.

9 May 2022

Infection with SARS-CoV-2 results in antibodies against common colds

A study published in the journal Science Advances uses electron microscopy-based polyclonal epitope mapping (EMPEM) methodology to elucidate the spike epitopes of β-HCoV targeted by preexisting serum antibodies and compares them to the epitopes targeted by antibodies elicited by SARS-CoV-2 infection using electron microscopy-based polyclonal epitope mapping (EMPEM) methodology.

8 May 2022

Scientists explore immunopathology of COVID-19

Researchers explored the interactions between severe acute respiratory syndrome coronavirus 2 and the host in the development of COVID-19.

6 May 2022

ACE2 News and Research

Researchers identify compounds from Aspergillus that may be effective against SARS-CoV-2

Development of a novel surface plasmon resonance-based assay to determine kinetics of SARS-CoV-2 spike – human ACE2 interaction

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

Researchers identify cellular serpins as host factors that restrict SARS-CoV-2 infection

Delta- and Omicron BA.1-variant specificity of B cell repertoires established by an initial Wuhan strain infection

Imprinted antibody responses towards SARS-CoV-2 Omicron subvariants

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

Antifungal agent Bifonazole as an antiviral against SARS-CoV-2

Discovery of host co-factors necessary for SARS-CoV2 infection

COVID-19-induced non-cell-autonomous anosmia

Decoy ACE2 nanoparticles block the entry of SARS-CoV-2 into cells

Evasion of COVID-19 vaccine-medicated mucosal immunity by SARS-CoV-2 Omicron

Research highlight reports on the observed differences in transmissibility and pathogenicity of Omicron vs. earlier variants of SARS-CoV-2

mRNA boosters enhance neutralization of SARS-CoV-2 BA.1, BA.2 and BA.3

Deoxyribonucleic acid nanostructure sensor found to rapidly detect and inhibit SARS-CoV-2

Differences in COVID-19 outcomes related to sex

Study reveals immune responses to SARS-CoV-2 peptides in COVID-19 convalescent patients

Infection with SARS-CoV-2 results in antibodies against common colds

Scientists explore immunopathology of COVID-19

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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