ACE2 News and Research

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What genes affect the COVID-19 gender imbalance?

Many studies have established that coronavirus disease 2019 (COVID-19) is more infective in men than women, and men are more at risk of severe disease. While some have suggested that behavioral differences could explain increased transmission to men, this does not explain the more morbid prognosis.

16 Nov 2021

How effective is the COMIRNATY BNT162b2 vaccine against the SARS-CoV-2 Lambda variant?

Now, researchers from Public Health Services Israel have been investigating a new variant called Lambda to see if it qualifies as a variant of concern. Their research is published in the journal Eurosurveillance.

16 Nov 2021

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Researchers recently conducted a study to identify host factors affecting cellular interactions of the SARS-CoV-2 spike protein.

16 Nov 2021

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

The current study analyzed the interaction of SARS-CoV-2 at the human maternal-fetal interface by using an advanced ex vivo model.

16 Nov 2021

Broad neutralization capability of potent nanobody against SARS-CoV-2 variants

A new study has described the molecular basis of the neutralization potency and breadth of nanobodies.

16 Nov 2021

Rapid finger stick test to detect antibodies against SARS-CoV-2 variants

A new preprint reports a semi-quantitative test that can measure neutralizing antibodies to the SARS-CoV-2 pathogen at the point of care, using a finger stick or venipuncture blood.

16 Nov 2021

Could drugs derived from microalgae be effective against COVID-19?

Researchers discuss the ability of some microalgae metabolites to prevent cytokine storm syndrome during COVID-19.

15 Nov 2021

Updated mapping of the human genetic architecture of COVID-19

In the present study, researchers presented extensive meta-analysis and added ten new genome-wide significant loci.

15 Nov 2021

Vaccination protects against COVID-19 related hospitalization in patients with and without comorbidity

Researchers from University Medical Centre Utrecht have been investigating the efficiency of vaccines against the alpha variant in the Netherlands.

15 Nov 2021

Detection of a coronavirus similar to SARS-CoV-2 in Cambodian bats

Now, a new study published in the journal Nature Communications reports the identification of SARS-CoV-2 related coronaviruses in two horseshoe bats sampled in Cambodia in 2010.

15 Nov 2021

Partial resistance to neutralizing antibodies and enhanced transmissibility of SARS-CoV-2 Delta variant

A new study estimates the efficacy of the immune response induced by vaccination and natural COVID-19 infection against the Kappa and Delta lineages.

14 Nov 2021

Impact of mutations on binding affinity of SARS-CoV-2 variants with ACE2 and existing antibodies

Researchers explained their analysis of the mechanisms that trigger the docking of SARS-CoV-2 variants to ACE2 and the antibodies, referred to as protein-protein docking.

12 Nov 2021

Study may pave the way for a more personalized approach to COVID-19 diagnosis and treatment

Using some of the most advanced molecular sequencing tools available to evaluate COVID-19 rapid autopsy tissues, researchers have identified four major regulatory pathways, specific molecular effectors behind COVID-19 symptoms, and differences that drive diverging clinical courses among individual patients.

11 Nov 2021

Analysis of immunodeficient patients granted REGEN-COV under compassionate use COVID-19 program

A team of scientists describe the safety and response to REGEN-COV® for COVID-19 patients with immunodeficiency-associated antibody disorders.

11 Nov 2021

Long-lasting anti-spike and anti-membrane antibodies can differentiate between COVID-19 infection and vaccination

Researchers have been investigating which other proteins remain prevalent long enough for tests against them to be worthwhile.

11 Nov 2021

Immunity following COVID-19 vaccination and natural infection in India

The researchers evaluated immune response markers in a cross-section of people from the Indian state of West Bengal, including those vaccinated with either Covishield or Covaxin, the unvaccinated cohort, and the naturally infected.

11 Nov 2021

Effectiveness of sotrovimab demonstrated in patients with mild to moderate COVID-19

In an attempt to study the safety and effectiveness of sotrovimab in more vulnerable patients suffering from mild to moderate symptoms of COVID-19, a multinational team of researchers conducted the COVID-19 Monoclonal antibody Efficacy Trial-Intent to Care Early (COMET-ICE) trial.

11 Nov 2021

Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

A German case study recently published in the journal Nature Communications has characterized a long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dynamics in an immunosuppressed kidney transplant recipient and provided evidence for the evolution of SARS-CoV-2 into potentially harmful immune escape mutants during persistent infections.

10 Nov 2021

Current understanding of the link between COVID-19 and cardiovascular disease

A review published in Chemo-Biological Interactions has focused on the prevalence of COVID-19 in CVD patients associated with ACE2 mechanisms.

10 Nov 2021

Mechanisms and strategies for antibody binding and escape in SARS-CoV-2

A new study investigated the mechanisms for binding and strategies to escape several hNAbs used by SARS-CoV-2 strains through molecular simulations.

10 Nov 2021

ACE2 News and Research

What genes affect the COVID-19 gender imbalance?

How effective is the COMIRNATY BNT162b2 vaccine against the SARS-CoV-2 Lambda variant?

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

Broad neutralization capability of potent nanobody against SARS-CoV-2 variants

Rapid finger stick test to detect antibodies against SARS-CoV-2 variants

Could drugs derived from microalgae be effective against COVID-19?

Updated mapping of the human genetic architecture of COVID-19

Vaccination protects against COVID-19 related hospitalization in patients with and without comorbidity

Detection of a coronavirus similar to SARS-CoV-2 in Cambodian bats

Partial resistance to neutralizing antibodies and enhanced transmissibility of SARS-CoV-2 Delta variant

Impact of mutations on binding affinity of SARS-CoV-2 variants with ACE2 and existing antibodies

Study may pave the way for a more personalized approach to COVID-19 diagnosis and treatment

Analysis of immunodeficient patients granted REGEN-COV under compassionate use COVID-19 program

Long-lasting anti-spike and anti-membrane antibodies can differentiate between COVID-19 infection and vaccination

Immunity following COVID-19 vaccination and natural infection in India

Effectiveness of sotrovimab demonstrated in patients with mild to moderate COVID-19

Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

Current understanding of the link between COVID-19 and cardiovascular disease

Mechanisms and strategies for antibody binding and escape in SARS-CoV-2

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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