Acetylation News and Research

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Acetylation (or in IUPAC nomenclature ethanoylation) describes a reaction that introduces an acetyl functional group into an organic compound. Deacetylation is the removal of the acetyl group.

COVID19's cytokine storm ushers in a local complement storm in the lungs

A new study published in the journal Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces the complement system as a dangerous weapon for viral infection.

12 Apr 2021

Ketogenesis has a protective effect on mitochondria, finds study

Ketone bodies are generally an alternative energy source during starvation, but in newborns, ketogenesis is active regardless of nutritional status. In a recent study from Kumamoto University (Japan), researchers analyzed the effects of ketogenesis in mice and found that it has a protective effect on cells by maintaining the function of mitochondria.

16 Mar 2021

Study reveals detailed map of glioblastoma in genetic, molecular detail

Glioblastoma is among the most aggressive and devastating of cancers. While rare compared with other cancers, it's the most common type of brain cancer.

12 Feb 2021

Study reveals molecular machinery that regulates membrane association of Arf proteins

The small GTPases of the ADP-ribosylation factor (Arf) family are key initiators of various physiological processes including secretion, endocytosis, phagocytosis, and signal transduction. Arf family proteins function to mediate the recruitment of cytosolic effectors to specific subcellular compartments.

7 Jan 2021

Repair protein may prevent damage to healthy cells during cancer therapy

A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.

9 Dec 2020

Researchers use proteogenomics to better understand the biological complexity of breast cancer

Researchers at Baylor College of Medicine, the Broad Institute of MIT and Harvard and other institutions have applied powerful proteogenomics approaches to better understand the biological complexity of breast cancer.

18 Nov 2020

Metabolic biomarkers could predict COVID-19 severity

A new study suggests that metabolic biomarkers could possibly predict the severity of COVID-19 in patients.

16 Nov 2020

Affinity-Bead Assisted Mass Spectrometry for Proteomics

In this interview, Ghaith Hamza from AstraZeneca talks to News-Medical Life Sciences about the basic principles of Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS) and how Affi-BAMS can help target specific proteins for proteomic applications.

From Bruker Life Sciences Mass Spectrometry 16 Nov 2020

Men and women may require different brain tumor therapy, study finds

The current study shows that the sex differences in the tumor phenotype vary with the effect of the enhancer regulatory molecule bound to Brd4 on the course of stem cell-like differentiation in male and female GBM cells. Inhibition of Brd4 by genetic and pharmacological factors also varies in males and females, both in vivo and in vitro.

11 Nov 2020

Study characterizes biochemical mechanism of cancer-linked enzyme

A new study led by scientists at IUPUI and Indiana University Bloomington is the first to describe a biochemical mechanism that increases the activity of a molecule whose presence is observed in many types of cancer.

21 Oct 2020

Epigenetic changes in the brain drive late-onset Alzheimer's disease

New findings suggest that late-onset Alzheimer's Disease is driven by epigenetic changes -- how and when certain genes are turned on and off -- in the brain. Results were published today in Nature Genetics.

28 Sep 2020

Enhancing the efficacy of anti-PD-L1 immunotherapy for cancer

For most people, there is no scarier diagnosis than that of cancer. While treatments including chemotherapy and radiotherapy have been used since the 1940s and late 1800s, respectively, immunotherapy has more recently emerged as a viable and successful approach to cancer treatment.

18 Sep 2020

Advances in Virus Epigenetics

Growing evidence shows viruses exploit epigenetic processes to control their life cycles but epigentic regulation of viral infections is not fully understood.

From Chromatrap® - Porvair Sciences Ltd 25 Aug 2020

Study reveals a promising method for treating multiple sclerosis

A research team led by neurobiologist Professor Claire Jacob has identified an important mechanism that can be used to control the restoration of myelin sheaths following traumatic injury and in degenerative diseases.

24 Aug 2020

SARS-CoV-2 ORF9c responsible for immune evasion and efficient infection of host

A recent study by researchers at the Sanford Burnham Prebys Medical Discovery Institute and the University of California San Francisco and published on the preprint server bioRxiv in August 2020 shows that a protein encoded by the subgenomic sequence ORF9c of SARS-CoV-2 is responsible for the low antiviral response in infected humans, enabling the successful replication of the virus in the host.

21 Aug 2020

Study reveals a new target for tuberculosis drug development

Biology students and faculty members from The University of Texas at El Paso have discovered a new target for tuberculosis drug development.

1 Jul 2020

Novel vaccine platform against COVID-19 based on engineered human mesenchymal stem cells

In a recent groundbreaking bioRxiv paper, Chinese researchers describe a novel approach towards coronavirus disease (COVID-19) vaccine design based on engineered human mesenchymal stem cells, with favorable and promising antibody response.

22 Jun 2020

Researchers explore how a small change in protein shape causes long-term consequences

Sometimes proteins misfold. When that happens in the human brain, the pileup of misfolded proteins can lead to neurodegenerative diseases like Alzheimer's, Parkinson's and ALS.

19 May 2020

Researchers identify biological mechanism in depressed individuals

University of Illinois at Chicago researchers report that in depressed individuals there are increased amounts of an unmodified structural protein, called tubulin, in lipid rafts -; fatty sections of a cell membrane -; compared with non-depressed individuals.

22 Apr 2020

Advanced paternal age associated with risk of neurodevelopmental disorders in children

It is no secret that genetic factors play a role in determining whether children have neurodevelopmental disorders. Maternal exposure to drugs and viral or bacterial illnesses can be detrimental too.

21 Apr 2020