Acute Lymphoblastic Leukemia News and Research

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Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells, the cells in the body that normally fight infections. There are two main types of white blood cells-lymphoid cells and myeloid cells. ALL affects lymphoid cells.

St. Jude discovers factors that accelerate resistance to Gleevec targeted therapy in lymphoblastic leukemia

Results of a study by investigators at St. Jude Children's Research Hospital provide strong evidence for why the drug imatinib (Gleevec), which has revolutionized the treatment of chronic myelogenous leukemia (CML), is often unable to prevent relapse of a particularly aggressive form of acute lymphoblastic leukemia (ALL).

29 Aug 2007

Rapamycin study is first stage in development of new treatment

Rapamycin isn't your ordinary potential anti-cancer drug…It had a long and somewhat exotic history before undergoing preclinical (laboratory-based) studies at St. Jude as part of a national Pediatric Preclinical Testing Program (PPTP) investigation of its anticancer activity.

23 Aug 2007

Study helps predict anesthesia-linked risks for children with chest tumors

Children with mediastinal masses - tumors in their chest outside the lungs - are at special risk for developing breathing problems when they undergo anesthesia. These young patients are of special concern to clinicians who must anesthetize them as part of their medical treatment.

23 Aug 2007

New St. Jude alliance with San Diego institutions helps advance fight against cancer

St. Jude Children's Research Hospital continues to define the forefront of clinical care and research by announcing the creation of a new alliance with two Southern California institutions: Rady Children's Hospital, San Diego; and the University of California, San Diego (UCSD).

1 Aug 2007

Adult survivors of childhood leukemia exercise less putting themselves at risk for obesity

Overcoming pediatric cancer may only mark the beginning of a young survivor's lifelong battle to stay healthy.

24 Jul 2007

New hope for childhood cancer sufferers

Scientists investigating drug therapies for children with Acute Lymphoblastic Leukaemia (ALL) have presented new data demonstrating for the very first time that a small molecule called ABT-737 can increase the effectiveness of standard therapies.

17 Jul 2007

New type of drug shows promise for chronic lymphocytic leukemia

A new type of engineered drug candidate has shown promise in treating chronic lymphocytic leukemia in both test tube and early animal tests, a new study shows.

29 Jun 2007

Inherited genes linked to toxicity of leukemia therapy

St. Jude investigators have discovered inherited variations in certain genes that make children with acute lymphoblastic leukemia (ALL) susceptible to the toxic side effects caused by chemotherapy medications.

23 Jun 2007

Study compares cord blood to bone marrow for transplants

Umbilical cord blood transplants may offer blood cancer patients better outcomes than bone marrow transplants, according to an analysis of outcome data performed at the Statistical Center, Center for Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee.

14 Jun 2007

Scientists develop a more human-like mouse model of cancer

A team led by Dana-Farber Cancer Institute scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

28 May 2007

Inherited variations in certain genes linked to toxicity of leukemia therapy

Investigators at St. Jude Children's Research Hospital have discovered inherited variations in certain genes that make children with acute lymphoblastic leukemia (ALL) susceptible to the toxic side effects caused by chemotherapy medications.

15 May 2007

Knocking out Mcl1 protein could aid leukemia treatment

An effective way to fight leukemia might be to knock out a specific protein that protects cancer cells from dying, a new study shows.

21 Apr 2007

New player in the development T-cell acute lymphoblastic leukemia

Leuven, Belgium -- Leukemia, or cancer of the bone marrow, strikes some 700 Belgians each year.

16 Apr 2007

Leukemic cells find safe haven in bone marrow

The cancer drug asparaginase fails to help cure some children with acute lymphoblastic leukemia (ALL) because molecules released by certain cells in the bone marrow counteract the effect of that drug, according to St. Jude investigators.

16 Apr 2007

New discovery suggests novel methods for treating acute lymphoblastic leukemia

Investigators at St. Jude Children's Research Hospital have discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic leukemia (ALL), the most common cancer in children.

8 Mar 2007

Researchers discover clues to the cause of T-cell acute lymphoblastic leukemia

Researchers' discovery of clues to the cause of T-cell acute lymphoblastic leukemia (T-ALL) - a form of pediatric cancer that has a very poor prognosis - could lead to the development of new targeted therapies for this extremely difficult disease.

20 Sep 2006

FDA expands use of Oncaspar to include treating children and adults with newly diagnosed acute lymphoblastic leukemia

The U.S. Food and Drug Administration (FDA) has expanded the approved use of Oncaspar to include treating children and adults with newly diagnosed acute lymphoblastic leukemia (ALL) as part of a multiple drug chemotherapy regimen.

25 Jul 2006

FDA grants accelerated approval for Sprycel (dasatinib)

FDA grants accelerated approval for Sprycel (dasatinib), a new oral treatment for patients with chronic myeloid leukemia (CML),

29 Jun 2006

Finding indicate why some kinds of Leukemia are more aggressive than others

New clues to why some kinds of leukemia are more aggressive and deadly than others are coming from research examining the types of genetic damage that allow some blood cells to grow out of control, scientists report.

28 Apr 2006