Adenosine Triphosphate (ATP) News and Research

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Scientists have identified a novel anti-tuberculosis (TB) compound

Scientists at Johnson & Johnson Pharmaceutical Research and Development have identified a novel anti-tuberculosis (TB) compound that works better and faster than the current standard of care in mouse models of TB infection.

14 Dec 2004

A gallery of highly-specific, gene and protein “mug shots” of cancer types would be a powerful for oncologists

Doctors would like to diagnose malignancies rapidly by matching them with highly-specific genetic “mug shots” based on the presence of characteristic mRNAs or proteins. This kind of specificity would facilitate screening and early detection, and would potentially allow targeted treatments specific to each type of cancer

4 Dec 2004

Novel enzyme in sperm is essential for spontaneous and independent movement

A study led by scientists at the University of North Carolina at Chapel Hill has found that a novel enzyme in sperm is essential for spontaneous and independent sperm movement as well as male fertility.

16 Nov 2004

Uncoupling proteins in the human heart

Results of a study in this week’s issue of THE LANCET suggest that respiratory uncoupling and reduced substrate availability might lead to energy deficiency in heart failure.

14 Nov 2004

Zetia co-administered with Fenofibrate significantly reduced LDL ("bad") cholesterol in mixed hyperlipidemia patients

Results from a new study showed that coadministration of Zetia (ezetimibe) and fenofibrate significantly reduced LDL ("bad") cholesterol (LDL-C), non-high density lipoprotein cholesterol (non-HDL-C) and apo B1 in patients with mixed hyperlipidemia and high LDL cholesterol when compared to fenofibrate alone.

9 Nov 2004

Mild pulses of electrical energy just as effective as more powerful and painful shocks to interrupt life-threatening rapid heartbeats

Ventricular tachycardia (VT) is a fast heartbeat originating in the heart’s ventricle chamber and can be life-threatening. VT is often treated with an implantable cardioverter-defibrillator (ICD), a device that delivers an electrical shock to restore an irregular heart rhythm.

22 Oct 2004

Energy blocker can eradicate large liver tumors

Building on their earlier work, Johns Hopkins researchers have discovered that an apparently nontoxic cellular "energy blocker" can eradicate large liver tumors grown in rats. Six months to more than a year after treatment was stopped, the rats are still cancer free.

18 Oct 2004

Ezetrol co-administration with statin therapy lowers LDL cholesterol in diabetics

Results from two new clinical trials show that patients with diabetes and metabolic syndrome who are treated with ezetimibe (EZETROL®) co-administered with a statin experience greater reductions in LDL (“bad”) cholesterol, compared to patients taking a statin alone.

7 Sep 2004

Ultra-sensitive measurement technique shows how biomolecular motors carry out essential tasks

In the human body, hundreds of different types of biomolecular motors help carry out such essential tasks as muscle contraction, moving chromosomes during cell division, and reloading nerve cells so they can repeatedly fire.

30 Aug 2004

Cholesterol guidelines advise more intensive treatment

Cardiologists at Temple University Hospital are working with area primary care physicians to help educate patients who are at moderate-to- high risk for heart attack about new guidelines for lowering cholesterol.

23 Aug 2004

Scientists visualise protein complex responsible for looking after out of shape proteins

The structure of the chaperonin complex of the bacteria Thermus thermophilus reveals clues about how the important molecule may do its job of folding new or damaged proteins within cells.

17 Aug 2004

Adenosine triphosphate is a culprit in causing the devastating damage of spinal cord injury

ATP - adenosine triphosphate, the vital energy source that keeps our body’s cells alive, runs amok at the site of a spinal cord injury, pouring into the area around the wound and killing the cells that normally allow us to move, scientists report in the cover story of the August issue of Nature Medicine.

29 Jul 2004

Updated guidelines for treatment of blood cholesterol

The National Cholesterol Education Program (NCEP) has updated its guidelines for treatment of blood cholesterol, suggesting that people at risk for heart attack and stroke would benefit from more intensive cholesterol-lowering therapies.

13 Jul 2004

Researchers shed new light on the function of huntingtin, the protein whose mutation underlies Huntington’s disease

CNRS and Inserm research scientists at the Institut Curie have shed new light on the function of huntingtin, the protein whose mutation underlies Huntington’s disease.

8 Jul 2004

New guidelines for treating heart attacks

If your chest pain worsens and lasts more than five minutes, especially if you’re short of breath, feel weak, nauseated or lightheaded, call 9-1-1—you could be having a heart attack.

8 Jul 2004

New compound, ZK-CDK combines the inhibition of tumour cell growth as well as inhibition of tumour angiogenesis in one single molecule

Treatment with a new dual cell cycle and angiogenesis pathway inhibitor blocks VEGF-induced vascular permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models

7 Jul 2004

By altering a single gene you could live longer and be thinner

Imagine that by altering the function of a single gene, you could live longer, be thinner and have lower cholesterol and fat levels in your blood.

30 Jun 2004

Magnetic resonance spectroscopy identifies women with chest pain at high risk

Women with chest pain who have a normal coronary angiogram can benefit from a test that detects abnormal metabolism in their heart muscle, according to a study reported in today’s rapid access issue of Circulation: Journal of the American Heart Association.

16 Jun 2004

Proteins transform DNA into molecular velcro

Proteins critical for compacting DNA in preparation for cell division actually interact with the double helix to fashion it into a kind of “molecular Velcro,” researchers have discovered.

5 Jun 2004

Research shows that treatment with nitric oxide after storage may dramatically improve the viability of transplanted livers

About 5,000 liver transplants are performed annually in the United States, and a key factor ensuring success is maintaining a healthy donor organ that can function effectively in the recipient. However, transplanted livers typically incur substantial damage when blood flow is restored to the organ after the transplant.

24 May 2004