Adenovirus News and Research

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Adenoviruses most commonly cause respiratory illness; however, depending on the infecting serotype, they may also cause various other illnesses, such as gastroenteritis, conjunctivitis, cystitis, and rash illness. Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. Acute respiratory disease (ARD), first recognized among military recruits during World War II, can be caused by adenovirus infections during conditions of crowding and stress.

Researchers identify molecular signatures to predict efficacy of malaria vaccines

The acid test for a vaccine is: "Does it protect people from infection?" Emory Vaccine Center researchers have analyzed this issue for a leading malaria vaccine called RTS,S, and their results have identified candidate signatures, or biomarkers, in the blood of vaccinated subjects which predict the likelihood of success from vaccination.

13 Feb 2017

New Zika vaccine candidate shows potential to protect against virus with single dose

A new Zika vaccine candidate has the potential to protect against the virus with a single dose, according to a research team led by scientists from the Perelman School of Medicine at the University of Pennsylvania.

2 Feb 2017

Valo Therapeutics develops novel oncolytic viral vaccines for treatment of multiple forms of cancer

A spin-out from the University of Helsinki, Valo Therapeutics is developing novel oncolytic viral vaccines for the treatment of multiple forms of cancer.

31 Jan 2017

Salk Institute researchers reveal how to curb immune enthusiasm

Normally when we think of viruses, from the common cold to HIV, we want to boost people's immunity to fight them.

20 Jan 2017

New research suggests novel combination approach to fight against gliomas

"Devastating" and "dismal." That's how leading researchers describe the present outlook for malignant brain tumors. The median survival rate for patients with glioblastoma multiforme, or GBM, is a mere 14.2 months.

4 Jan 2017

Childhood diarrhea from pathogens more common than previously thought?

The number of cases of childhood diarrhea, and its mortality toll of 500,000 per year, has not changed. Now, however, we can explain ~90% of the cases to specific pathogens. We can assign responsibility.

15 Dec 2016

Experimental vaccine/immune stimulant combination may lead to viral remission in HIV patients

A study led by researchers at Beth Israel Deaconess Medical Center, in collaboration with scientists at Walter Reed Army Institute of Research, Janssen Vaccines & Prevention B.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson and Gilead Sciences, Inc., has demonstrated that combining an experimental vaccine with an innate immune stimulant may help lead to viral remission in people living with HIV.

9 Nov 2016

Investigational treatment combination improves virologic control in SIV-infected monkeys

Researchers have found that an investigational treatment combination of a therapeutic vaccine and an immune-stimulator improves virologic control and delays viral rebound following the discontinuation of antiretroviral therapy (ART) in non-human primates infected with SIV, the simian form of HIV.

9 Nov 2016

DNAtrix enters into license agreement with University of Florida to develop new oncolytic virus platform

DNAtrix, a clinical stage biotechnology company developing virus-driven immunotherapies for cancer, announced it has entered into an exclusive license agreement with the University of Florida, Gainesville to develop a novel oncolytic virus platform.

8 Nov 2016

Study provides unprecedented insights into causes of childhood diarrhea

New research offers unprecedented insights into the causes of childhood diarrhea, the second-leading cause of death of children worldwide, and suggests that the role of pathogens such as bacteria, viruses and parasites has been vastly underestimated.

13 Oct 2016

Two Zika vaccine candidates protect newborn mice against neurological damage

Two vaccines against Zika virus developed at the University of Pittsburgh School of Medicine have successfully conveyed immunity from female mice to pups conceived weeks after the mother's vaccination.

4 Oct 2016

New research shows childhood diarrhea cases significantly higher than estimated

The number of cases of childhood diarrhoea attributable to pathogens (bacteria, parasites, viruses or other infections) have been substantially underestimated and may be nearly twice as high as previous analysis suggests, according to new research published in The Lancet.

24 Sep 2016

Three vaccine candidates provide complete protection against Zika virus in rhesus monkeys

A month after announcing that two promising vaccine candidates provided mice with complete protection against the Zika virus, a research team at Beth Israel Deaconess Medical Center, in collaboration with scientists at Walter Reed Army Institute of Research and the University of São Paulo, now reports achieving complete protection against Zika virus in rhesus monkeys.

5 Aug 2016

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

“IDPs” is now a widely used acronym that stands for “intrinsically disordered proteins.” It is the term generally used by the scientific community to refer to a wide variety of proteins that do not have a stable 3D structure and are instead characterized by a high extent of local mobility, disorder and many conformers that are accessible at room temperature.

From Bruker BioSpin - NMR, EPR and Imaging 30 Jun 2016

Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

Viruses must avoid a host's immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses.

30 Jun 2016

Two Ebola vaccine candidates show promise in clinical trial

An immunization regimen using two Ebola vaccine candidates was safe and well-tolerated and induced an immune response in healthy adult volunteers in a Phase 1 clinical trial.

20 Apr 2016

Genetic modification of common virus gives extra weapon to kill cancer cells

A common flu virus could be used to overcome patients' resistance to certain cancer drugs -- and improve how those drugs kill cancer cells, according to new research from Queen Mary University of London.

16 Apr 2016

Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Researchers report photoimmunotherapy to be effective against elusive gastric cancer cells following transduction with the gene that expresses the extracellular domain protein of HER2. The results are published in the journal Small Molecule Therapeutics in February 2016.

15 Mar 2016

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Researchers show that the protein CCN4 positively regulates the generation of cartilage matrix, which are depleted in osteoarthritis.

2 Mar 2016

Swedish research group publishes scientific discoveries concerning EKC in Acta Ophthalmologica journal

A Swedish research group at St. Erik Eye Hospital, Stockholm, Karolinska Institutet, Solna, and Umeå University has published scientific discoveries concerning the serious infectious eye disease EKC in the prestigious journal Acta Ophthalmologica.

22 Jan 2016