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Tackling antibiotic resistance head-on with CRISPR

With modern advances in genetic engineering occurring almost every day, the latest discovery concerns antibiotic resistance. Using the powerful gene editor CRISPR, scientists reported the development of a gene-drive system that is 100 times as efficient as other current systems at inactivating a specific bacterial gene responsible for making the bacterium antibiotic-resistant and which is present as multiple copies within the same bacterial cell.

16 Dec 2019

New gene technology shows 100-fold efficiency in targeting antibiotic-resistant bacteria

Taking advantage of powerful advances in CRISPR gene editing, scientists at the University of California San Diego have set their sights on one of society's most formidable threats to human health.

16 Dec 2019

People with salmonella infection more likely to be hospitalized longer

Salmonella is acting up in Michigan, and it could be a model for what's happening in other states, according to a new Michigan State University study.

25 Nov 2019

Bacteriophages could treat E. coli without damaging the gut, new study says

Researchers in the US have developed a new therapy that uses a unique bacteriophage to treat E. coli infections.

13 Nov 2019

New clinical practice guideline published for adults with community acquired pneumonia

The American Thoracic Society and the Infectious Diseases Society of America have published an official clinical guideline on the diagnosis and treatment of adults with community acquired pneumonia (CAP) in the ATS's Oct. 1 American Journal of Respiratory and Critical Care Medicine.

1 Oct 2019

African bacterium resists almost all drugs

It looks like it’s time to pay the piper. The first extensively drug-resistant (XDR) strain of Salmonella typhimurium, called ST313 sublineage II.1, has cropped up in the Democratic Republic of Congo (DRC). This fails to respond to any of the antibiotics that are commonly used in the DRC, except for ciprofloxacin. And to make things worse, one sample has been isolated that shows incomplete response even to this last drug.

22 Sep 2019

Antibiotic resistance in dolphins mirrors disturbing trend in humans

Antibiotic resistance in bottlenose dolphins shows that up to 88% of pathogenic organisms in this species is resistant to one or more antibiotics. This finding offers very useful insights into the identical phenomenon in humans. This species is termed a sentinel species, which means it reflects environmental risks to humans in advance of their occurrence in humans.

16 Sep 2019

Researchers reveal virulence regulatory mechanism in a superbug

As antibiotic resistance is growing and posing a threat on public health, developing new antibiotics has become more urgent than ever.

4 Jul 2019

New machine-learning approach discovers mechanism that helps antibiotics kill bacteria

Most antibiotics work by interfering with critical functions such as DNA replication or construction of the bacterial cell wall.

10 May 2019

Treatment with antibiotic reduces the size of endometriosis-related lesions in mice

Researchers at Washington University School of Medicine in St. Louis have found, in mice, that treatment with an antibiotic reduces the size of lesions caused by endometriosis.

30 Apr 2019

Simple, inexpensive test quickly detects antibiotic-resistant 'superbugs'

When you get sick, you want the right treatment fast. But certain infectious microbes are experts at evading the very anti-bacterial drugs designed to fight them.

16 Oct 2018

Study aims to investigate antimicrobial resistance of uropathogenic E. coli from elderly patients

Urinary Tract Infection is a common cause of morbidity and mortality in older adults. Escherichia coli is one of the bacterial agents with higher prevalence in community-acquired and health care associated urinary infections in elderly patients.

27 Sep 2018

UH researchers win $3.5 million grant to develop technology that combats multi-drug resistant bacteria

Two UH researchers have won a five-year, $3.5 million grant from the National Institute of Allergy and Infectious Diseases to develop technology that will quickly suggest the most promising combinations of antibiotics to kill certain resistant bacteria.

30 Aug 2018

Antibiotic use linked to higher risk of severe viral disease in mice

People infected with West Nile virus can show a wide range of disease. Some develop life-threatening brain infections. Others show no signs of infection at all. One reason for the different outcomes may lie in the community of microbes that populate their intestinal tracts.

27 Mar 2018

Study finds high rate of neonatal infections in Madagascar

Every year in the world, 4 million children die before the age of one, mainly in resource-limited countries, one-third of them due to a severe infection. The neonatal period alone (first month of life) accounts for one third of deaths before the age of one.

27 Feb 2018

MIT researchers discover new way to make bacteria vulnerable to existing antibiotics

MIT researchers have discovered a way to make bacteria more vulnerable to a class of antibiotics known as quinolones, which include ciprofloxacin and are often used to treat infections such as Escherichia coli and Staphylococcus aureus.

8 Dec 2017

Combination therapy with azithromycin found to be unnecessary in most children with pneumonia

A combination of two antibiotics is often prescribed to treat community-acquired pneumonia in children but a JAMA Pediatrics study is now showing that using just one of the two has the same benefit to patients in most cases.

2 Nov 2017

New study links hepatic inflammation to western diet

A new study in The American Journal of Pathology reports that mice fed a Western diet, which is high in fat and sugar, resulted in hepatic inflammation, especially in males. Moreover, liver inflammation was most pronounced in Western diet-fed male mice that also lacked farnesoid x receptor (FXR), a bile acid receptor.

12 Jul 2017

Brazilian researchers reveal nanoparticle-based strategy to combat antibiotic-resistant bacteria

A new strategy to combat antibiotic-resistant bacteria has been described by Brazilian researchers in Scientific Reports, an online journal owned by Springer Nature.

11 Jul 2017

Preserved placenta is associated with risk of infection

A recent case study published by Centers for Disease Control and Prevention highlighted that capsules of dehydrated placenta prepared for human consumption can be a source of infectious agents.

30 Jun 2017