Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

IPIAD augments standard therapy for pancreatic ductal adenocarcinoma

A new research perspective was published in Oncoscience (Volume 11) on February 7, 2024, entitled, "IPIAD- an augmentation regimen added to standard treatment of pancreatic ductal adenocarcinoma using already-marketed repurposed drugs irbesartan, pyrimethamine, itraconazole, azithromycin, and dapsone."

9 Feb 2024

Combination treatments reduce blood pressure in patients taking ibrutinib

Combination treatments with two or more blood pressure drugs can significantly reduce blood pressure in patients taking ibrutinib, according to a new study published in Blood Advances.

5 Feb 2024

Curcumin spray shows promise in fighting SARS-CoV-2 and flu viruses

A study in the Virology Journal reveals a curcumin-containing oro-nasal film spray with potential antiviral activity against SARS-CoV-2 and influenza viruses, boosting mucosal immunity without cytotoxic effects.

24 Jan 2024

Wearable blood pressure monitoring for assessing remote blood pressure regulation

The prevalence of controlled hypertension using a wearable blood pressure (BP) device.

23 Jan 2024

Persistent presence of SARS-CoV-2 RNA found in long COVID patients

Researchers conduct blood digital transcriptomics to determine the persistence of SARS-CoV-2 RNA in patients with long COVID-19.

23 Jan 2024

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Researchers compared SARS-CoV-2 Omicron variant of concern replication in human cell lines and primary airway cultures and measured host responses to infection.

19 Jan 2024

Study shows engineered antibodies significantly boost Omicron neutralization

Researchers engineered IgA antibodies from IgG monoclonals, enhancing neutralization against Omicron by up to 75-fold and offering protection in mice models.

10 Jan 2024

COMPANION study of digital therapy demonstrates reduced anxiety in patients with pulmonary fibrosis

Vicore Pharma Holding AB (publ), unlocking the potential of a new class of drug candidates, angiotensin II type 2 receptor agonists (ATRAGs), today announced positive results of the COMPANION study (NCT05330312), investigating the efficacy of AlmeeTM, a 9-week digital cognitive behavioral therapy (CBT) accessed through a smartphone or tablet.

8 Jan 2024

Does SARS-CoV-2's ability to infect humans stem from its evolutionary past?

Study challenges the hypothesis of genetic recombination in SARS-CoV-2's evolution, suggesting its ancestral virus already possessed human-infecting traits, based on analyses of over 100 viral genomes.

7 Jan 2024

Common heart medication causes false positives on Alzheimer's blood test

Researchers from the University of Gothenburg, in collaboration with colleagues from University of Glasgow, present data that the drug Entresto (sacubitril/valsartan) which is commonly used for the treatment of cardiac failure leads to a marked reduction in plasma Aβ ratio, a candidate blood test for Alzheimer's disease (AD).

18 Dec 2023

Experimental drug paired with a standard-care medication offers hope for kidney disease patients

In a clinical trial of patients with chronic kidney disease, an experimental drug significantly reduced albuminuria -; albumin in urine, a sign of kidney damage -; for 50% of participants.

15 Dec 2023

IFNγ identified as crucial for reducing pulmonary viral loads in COVID-19, new research shows

The role of type-2 interferon (IFNγ) in antiviral immunity.

14 Dec 2023

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants

Five DNA vaccine candidates based on different SARS-CoV-2 strains.

12 Dec 2023

New SARS-CoV-2 variant JN.1 shows increased transmissibility and immune resistance

A Japanese study published in BioRxiv explores the virological characteristics of the SARS-CoV-2 JN.1 variant, finding it has a higher effective reproductive number and stronger resistance to immunity from other variants, potentially due to the L455S spike protein mutation.

11 Dec 2023

$Optimizing guideline-directed medical therapy for heart failure with reduced ejection fraction$

Optimizing guideline-directed medical therapy for heart failure with reduced ejection fraction

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Over the past several decades, major strides have been made in the management of heart failure with reduced ejection fraction (HFrEF).

5 Dec 2023

Novel mRNA vaccine GLB-COV2-043 shows high efficacy against COVID-19 variants in early trials

The safety, efficacy, and immunogenicity of a mRNA-based vaccine.

5 Dec 2023

Omicron infection linked to brain structure changes in men, study finds

Study reveals that men infected with the SARS-CoV-2 Omicron variant experience changes in brain structure, including reduced gray matter thickness and subcortical nuclear volume. These findings, based on MRI data and clinical symptoms, highlight the neurological impact of Omicron infection, contributing to our understanding of COVID-19's effects on the brain.

4 Dec 2023

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