Anti Epileptic Drug News and Research

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Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia

Long-term therapy with some antiepileptic drugs and antibiotics can cause osteomalacia, a condition marked by softening of the bones that is usually the result of vitamin D and calcium deficiency.

16 May 2006

Treatments for epilepsy compared

In a comprehensive analysis and mathematical model of the available scientific data, researchers at the University of York on behalf of the National Institute of Health and Clinical Excellence (NICE) in the United Kingdom found that newer drugs used to treat the most common forms of epilepsy are more expensive than older drugs, but produce similar health benefits.

30 Dec 2005

Epilepsy surgery improves depression

According to a new multicenter study patients with epilepsy which does not respond to drug therapy, and who also have depression or anxiety, surgery used to treat the epilepsy often results in improvements in the psychiatric symptoms.

14 Dec 2005

PET brain scans of a brain chemical messenger system may prove sensitive enough to help plan brain surgery for epilepsy

When drugs fail to control epilepsy, brain surgery is often the only remaining therapeutic option. However, identifying the correct spot for surgery has traditionally required a separate preliminary -- and inherently risky -- surgical procedure.

26 Sep 2005

Stroke sufferers at increased risk of developing epilepsy

Researchers in Norway determined that stroke severity measured by the Scandinavian Stroke Scale is a statistically significant predictor for epilepsy after stroke. Data shows that more than 20,000 Americans will develop epilepsy due to stroke each year. This research is published in the August issue of the journal Epilepsia.

6 Sep 2005

First evidence that complex genetic interactions account for autism risk

Using a novel analysis of the interactions among related genes, Duke University Medical Center researchers have uncovered some of the first evidence that complex genetic interactions account for autism risk. The Duke team found that the brain mechanism that normally stops or slows nerve impulses contributes to the disease.

3 Aug 2005

FDA approval for VNS Therapy will help people with epilepsy

The U.S. Food and Drug Administration's recent approval of Vagus Nerve Stimulation Therapy for treatment of chronic depression provides a novel single-treatment option for two major symptoms suffered by people with epilepsy.

21 Jul 2005

Neurological complication may result from rapid withdrawal from pregabalin

A report in the July Annals of Neurology describes a serious adverse event experienced by a participant in a clinical trial that may raise a new caution about the use of antiepileptic drugs for conditions other than epilepsy.

6 Jul 2005

No need to rush to take epilepsy drugs

A new study from the UK says that it is not neccessary to rush to put people on drugs if they have only infrequent seizures.

12 Jun 2005

No significant long-term benefit in administering immediate treatment to those with early epilepsy

Around 500,000 people in the UK suffer from epilepsy, making it the most common serious neurological condition. Many of those who develop epilepsy start having seizures during childhood, but it can develop at any age.

10 Jun 2005

Giving individuals with single or infrequent seizures immediate treatment does not reduce their risk of seizure recurrence in the long-term

Between 1993 and 2000, David Chadwick (University of Liverpool, UK) and colleagues, recruited around 1400 patients with single or infrequent seizures from centres in the UK and around the world.

9 Jun 2005

Pregnant women with epilepsy face dilemma - continue treatment and risk birth defects

An article in the journal Epilepsia reviewed recent data on the risks associated with continuation of medical treatment of women with epilepsy during their pregnancies.

22 Apr 2005

Gene variations explain drug dose required to control seizures

Determining which variants of particular genes patients with epilepsy carry might enable doctors to better predict the dose of drugs necessary to control their seizures, suggest basic findings by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and the University College London.

28 Mar 2005

Mixed results on the effects of epilepsy drugs taken during pregnancy

New studies show mixed results on the effects of epilepsy drugs taken during pregnancy. With a newer drug, lamotrigine, the risk of birth defects was similar to that in women without epilepsy. But long-time epilepsy drug valproic acid, or sodium valproate, does increase the risk of birth defects.

22 Mar 2005

Anticonvulsant drug valproate poses greater birth-defect risk than suspected

Use of the anticonvulsant drug valproate during pregnancy may pose a significantly great risk of birth defects than does use of other antiseizure medications.

22 Mar 2005

The good news and the bad news on epilepsy drugs for pregnant women

Two new studies on the effects of epilepsy drugs taken during pregnancy show mixed results. The risk of birth defects with a newer drug, lamotrigine, was similar to that in women without epilepsy.

21 Mar 2005

New study details trends in diagnosis, treatment of brain tumours

A two year study involving over 560 patients with the newly-diagnosed malignant brain tumors shows that patterns of care are varied and there is a need for new, detailed clinical guidelines for management of brain tumors. The study is published in the Feb. 2, 2005 issue of the Journal of the American Medical Association (JAMA).

3 Feb 2005

Botox may be a possible treatment for sufferers of Tourette's syndrome

Researchers at Baylor College of Medicine in Houston are using botulinum toxin type A (Botox) to treat the neurological disorder, which can cause involuntary motor and vocal tics.

21 Dec 2004

The Royal Society of Medicine Press has published new Primary Care Guidelines for the Management of Females with Epilepsy

These guidelines were produced following a multidisciplinary consensus meeting of epilepsy experts and cover such topics as the diagnosis and treatment of epilepsy, preconception counselling and the management of epilepsy during and after pregnancy.

3 Nov 2004

Anti-epilepsy drug sodium valproate is associated with developmental delay and lower IQ

Around five in every 1000 people will have epilepsy. One in three people with epilepsy is a woman of childbearing age, and one in every 200 women attending antenatal clinics is being treated with anti-epileptic drugs.

13 Oct 2004