Anti Epileptic Drug News and Research

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Electroclinical triggers for repeat MRI in intractable epilepsy identified

Researchers have outlined the electroclinical features typically associated with bottom-of-sulcus dysplasia, the surgical removal of which often cures epilepsy in affected patients.

30 Apr 2015

Upsher-Smith presents favorable data from PREVAIL OLE study of Qudexy XR capsules

Upsher-Smith Laboratories, Inc. presented data from a 52-week, open-label extension study (PREVAIL OLE) showing that Qudexy XR (topiramate) extended-release capsules offered a long-term adjunctive treatment option with a favorable tolerability profile for a high proportion of patients with refractory partial-onset seizures (POS).

21 Apr 2015

Existing epilepsy drug reverses aMCI in elderly patients at risk for Alzheimer's disease

A novel therapeutic approach for an existing drug reverses a condition in elderly patients who are at high risk for dementia due to Alzheimer's disease, researchers at Johns Hopkins University found.

12 Mar 2015

Direct brain responsive neurostimulator reduces seizures, improves quality of life

Piotr Olejniczak, MD, PhD, LSU Health New Orleans Professor of Neurology and Director of the Epilepsy Center, contributed to a study of the long-term effectiveness of the first direct brain responsive neurostimulator for partial onset, or focal, seizures that cannot be controlled with medication.

25 Feb 2015

Study shows how cannabidiol works within cells

A team of Stony Brook University researchers have identified fatty acid binding proteins (FABPs) as intracellular transporters for two ingredients in marijuana, THC and CBD (cannabidiol).

13 Feb 2015

Researchers discover novel compound that helps curtail progression of temporal lobe epilepsy

Researchers at the LSU Health New Orleans Neuroscience Center of Excellence have found that a novel compound they discovered helps curtail the onset and progression of temporal lobe epilepsy.

28 Jan 2015

Alexza begins Phase 2a study of AZ-002 for ARS-related epilepsy management

Alexza Pharmaceuticals, Inc. announced today that it has initiated a Phase 2a study of AZ-002 (Staccato alprazolam), which is being developed for the management of epilepsy in patients with acute repetitive seizures (ARS).

22 Jan 2015

Knowledge and access barriers bar epilepsy patients from surgery

The unfamiliarity of some neurologists with recommended practice standards, coupled with access barriers, may be preventing eligible patients with epilepsy from undergoing surgical treatment, survey findings suggest.

18 Dec 2014

Chemical chaperone: A new therapeutic option for epilepsy

Researchers found out that the conformational defect in a specific protein causes Autosomal Dominant Lateral Temporal Lobe Epilepsy (ADLTE) which is a form of familial epilepsy. They showed that treatment with chemical corrector called "chemical chaperone" ameliorates increased seizure susceptibility in a mouse model of human epilepsy by correcting the conformational defect.

10 Dec 2014

‘Landmark’ study confirms aetiology effect on epilepsy mortality risk

A “landmark” meta-analysis confirms the increased mortality risk in patients who have symptomatic or cryptogenic epilepsy.

2 Dec 2014

Study identifies new gene for progressive form of epilepsy

A study led by researchers at University of Helsinki, Finland and Universities of Melbourne and South Australia has identified a new gene for a progressive form of epilepsy. The findings of this international collaborative effort have been published today, 17 November 2014, in Nature Genetics.

18 Nov 2014

Epileptic mothers in the dark about pregnancy risk?

A new study has highlighted the need for more research into the safety of using anti-epileptic drugs during pregnancy.

30 Oct 2014

International researchers identify novel causes for severe childhood epilepsies

In the largest collaborative study so far, an international team of researchers, including scientists from VIB and Antwerp University identified novel causes for severe childhood epilepsies.

26 Sep 2014

Perampanel does not offer added benefit for patients with Epilepsy

The drug perampanel (trade name Fycompa) has been approved since July 2012 as adjunctive ("add-on") therapy for adults and children aged 12 years and older with epileptic fits (seizures).

20 Aug 2014

Researchers identify genetic variants associated with severe skin reactions to antiepileptic drug

Researchers have identified genetic variants that are associated with severe adverse skin reactions to the antiepileptic drug phenytoin, according to a study in the August 6 issue of JAMA.

6 Aug 2014

New study show direct link between depression and medication nonadherence

A new study led by Alan B. Ettinger, M.D., M.B.A., Director of the Epilepsy Center at Neurological Surgery, P.C., has found that many patients who fail to take their antiseizure medications are suffering from depression.

12 Jun 2014

Scientists develop new molecule for monitoring drug concentration

Monitoring the drug concentration in patients is critical for effective treatment, especially in cases of cancer, heart disease, epilepsy and immunosuppression after organ transplants.

9 Jun 2014

MRI-guided SLAH procedure provides safe, effective alternative to surgery

For patients with mesial temporal lobe epilepsy (MTLE) that can't be controlled by medications, a minimally invasive laser procedure performed under MRI guidance provides a safe and effective alternative to surgery, suggests a study in the June issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

3 Jun 2014

Biologists show bioelectrical signals control tumors arising from cancer-causing genes, fatty acid

Developmental biologists at Tufts University, using a tadpole model, have shown that bioelectrical signals from distant cells control the incidence of tumors arising from cancer-causing genes and that this process is impacted by levels of a common fatty acid produced by bacteria found in the tadpole and also in humans.

28 May 2014

Study examines potential use of medical marijuana, CBD in treating epilepsy

The therapeutic potential of medical marijuana and pure cannabidiol (CBD), an active substance in the cannabis plant, for neurologic conditions is highly debated.

23 May 2014