Antibiotic News and Research

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Antibiotics are drugs used to treat infections caused by bacteria and other microorganisms.

Antivirals from shark cartilage compound squalamine

A unique compound originally isolated from sharks could prove to be a promising treatment for hepatitis B and C and other viral diseases, researchers say. Known as squalamine, the drug has not yet been tested as an antiviral agent in humans, but it has been given to hundreds of people enrolled in clinical trials designed to test its usefulness for other conditions. Researchers say they hope to begin human trials to test the compound’s antiviral activity within the next year.

21 Sep 2011

A code beyond DNA: Modified tRNA bases are characteristic of species

Our genetic code consists of four “letters” in the form of the nucleobases in our DNA and RNA. Three letters together form a “word” that are translated into an amino acid by tRNA and combined into proteins. Special markings subdivide the gene into active and inactive regions. A third possible level of information has so far received less attention: the chemical modification of tRNA nucleobases. In the journal Angewandte Chemie Thomas Carell and a team at the University of Munich have now demonstrated that tRNA modification profiles can be used for the characterization of species and the differentiation of pathogenic and nonpathogenic bacterial strains.

20 Sep 2011

FoxM1 protein plays a critical role in development of medulloblastomas

Medulloblastomas constitute the most frequent class of malignant childhood brain tumor. Tumors of this type arise due to the uncontrolled proliferation of immature nerve cells in the developing brain, and there is no targeted treatment available.

20 Sep 2011

Powerful new antibiotic treatment for MRSA and C. difficile bugs

MGB Biopharma, a biopharmaceutical company which has licensed technology from the University of Strathclyde in Glasgow, Scotland, is developing a powerful new antibiotic treatment for resistant infections including the deadly MRSA and Clostridium difficile (C. diff.) bugs.

20 Sep 2011

Additional data on safety, tolerability of Cempra's solithromycin to be presented at 51st ICAAC

Cempra Pharmaceuticals today announced abstracts to be presented on its fourth generation macrolide and novel fluoroketolide antibiotic, solithromycin (CEM-101), at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 17 to 20, 2011, in Chicago. The abstracts provide additional data that demonstrate the safety and routes of administration of CEM-101, a new generation macrolide.

17 Sep 2011

Researchers develop polymers that fluoresce in the presence of bacteria

Researchers at the University of Sheffield have developed polymers that fluoresce in the presence of bacteria, paving the way for the rapid detection and assessment of wound infection using ultra-violet light.

16 Sep 2011

New paper describes unique process that is central to induction of MSRA antibiotic resistance

A new paper by a team of University of Notre Dame researchers that included Shahriar Mobashery, Jeffrey Peng, Brian Baker and their researchers Oleg Borbulevych, Malika Kumararasiri, Brian Wilson, Leticia Llarrull, Mijoon Lee, Dusan Hesek and Qicun Shi describes a unique process that is central to induction of antibiotic resistance in the problematic bacterium methicillin-resistant Staphylococcus aureus.

16 Sep 2011

Longer looks: Fighting antibiotic resistance; a health care arms race video; the HVP debate

We won't stop the rising tide of infections until we develop a new business model to fight them. We are not quite on the brink of some dystopian Victorian future. But every year, the prognosis for infectious-disease patients gets a bit grimmer. … And more-powerful drugs tend to cost more than the old drugs. … Even in the rich world, death from infection still looms; MRSA alone kills thousands every year. And firms are not developing antibiotics as fast as they used to.

16 Sep 2011

Azithromycin gel may treat borreliosis in humans

Blood-sucking ticks are not just a nuisance, they can also transmit dangerous diseases. One of them is Lyme disease, which is caused by bacteria of the genus Borrelia, and requires a course of treatment with antibiotics lasting several weeks. LMU researchers have come up with a quicker alternative.

16 Sep 2011

Cempra's solithromycin demonstrates efficacy comparable to levofloxacin for CABP treatment

Cempra Pharmaceuticals today announced results from its Phase II clinical trial investigating the efficacy, safety and tolerability of oral administration of our fourth generation macrolide, solithromycin (CEM-101), a fluoroketolide antibiotic, in comparison with oral levofloxacin for the treatment of community-acquired bacterial pneumonia (CABP).

15 Sep 2011

China Botanic third-quarter net sales increase 33.6% to $12.4 million

China Botanic Pharmaceutical Inc., a developer, manufacturer and distributor of botanical products, bio-pharmaceuticals and traditional Chinese medicines in China, today announced financial results for the three months ended July 31, 2011.

15 Sep 2011

Without action to curb antibiotic resistance, some diseases may once again become untreatable

In this Atlantic Magazine opinion piece, Megan McArdle, senior editor at the Atlantic, echoes a warning by the FDA issued in 2001 which stated, "Unless antibiotic resistance problems are detected as they emerge, and actions are taken to contain them, the world could be faced with previously treatable diseases that have again become untreatable, as in the days before antibiotics were developed."

15 Sep 2011

ASM to honor LA BioMed investigator for A. baumannii infection study

Ashraf Ibrahim, Ph.D., principal investigator at LA BioMed who specializes in infectious diseases, was recently honored by the American Society for Microbiology (ASM) and the ICAAC Program Committee in the area of Therapy and Prevention of Microbial Disease.

14 Sep 2011

Viewpoints: Burgess, Clancy and others on hospital infections; state health exchanges causing controversy

Hospital CEOs can do more than just prevent an outbreak of influenza in their facility this flu season: They can and must take action against antibiotic resistance, an urgent public health problem that affects us all. What does the flu have to do with antibiotic resistance and what can a hospital CEO do about it? Plenty, as it turns out.

13 Sep 2011

Taiwan residents to receive two month free access to The Cochrane Library

Taiwan residents will receive free access to The Cochrane Library in August and September 2011, in collaboration with the Taiwan Evidence Based Medicine Association at their Annual Conferencein September, whereDr. Charles Young, VP and Publishing Director for Global Clinical Solutions, atThe Cochrane Library's publisher, Wiley-Blackwell, will be presenting a session.

12 Sep 2011

Chemical biology researchers to meet at Scientific Oktoberfest in München

The "Scientific Oktoberfest" will be this year's meeting point for some of the internationally most distinguished researchers in the field of Chemical Biology. The so-called "CIPSM Fest of Chemical Biology" will be held from the 15th to the 16th of September in the Department of Chemistry of the Ludwig-Maximilians-Universität (LMU) München.

9 Sep 2011

Duties, role of clinical laboratory microbiologists could change significantly in the future

With the increasing availability of sophisticated technologies to rapidly diagnose and treat infectious diseases, the duties and the role of clinical laboratory microbiologists, who traditionally perform these tests, could see significant changes in the next few years. That is one of the conclusions of a series of reports published in a special supplement to the September 2011 Journal of Clinical Microbiology.

9 Sep 2011

Study identifies genes never before linked to antibiotic resistance in enterococci

An analysis of the genome of a superbug has yielded crucial, novel information that could aid efforts to counteract the bacterium's resistance to an antibiotic of last resort.

9 Sep 2011

Mass. Eye and Ear receives NIAID grant to coordinate Harvard-wide Project on Antibiotic Resistance

The Massachusetts Eye and Ear Infirmary has received an $11 million grant from the National Institute of Allergy and Infectious Disease, the largest National Institutes of Health grant in this hospital's187-year history, to coordinate the Harvard-wide Project on Antibiotic Resistance.

8 Sep 2011

Adding azithromycin to usual daily treatment for COPD reduces acute exacerbations by 27%

Richard Casaburi, Ph.D., M.D., principal investigator at Los Angeles Biomedical Research Institute (LA BioMed), is co-author of a recent study that should help improve the condition for the millions of individuals who suffer from chronic obstructive pulmonary disease, better known as COPD.

8 Sep 2011

Antibiotic News and Research

Further Reading

Antivirals from shark cartilage compound squalamine

A code beyond DNA: Modified tRNA bases are characteristic of species

FoxM1 protein plays a critical role in development of medulloblastomas

Powerful new antibiotic treatment for MRSA and C. difficile bugs

Additional data on safety, tolerability of Cempra's solithromycin to be presented at 51st ICAAC

Researchers develop polymers that fluoresce in the presence of bacteria

New paper describes unique process that is central to induction of MSRA antibiotic resistance

Longer looks: Fighting antibiotic resistance; a health care arms race video; the HVP debate

Azithromycin gel may treat borreliosis in humans

Cempra's solithromycin demonstrates efficacy comparable to levofloxacin for CABP treatment

China Botanic third-quarter net sales increase 33.6% to $12.4 million

Without action to curb antibiotic resistance, some diseases may once again become untreatable

ASM to honor LA BioMed investigator for A. baumannii infection study

Viewpoints: Burgess, Clancy and others on hospital infections; state health exchanges causing controversy

Taiwan residents to receive two month free access to The Cochrane Library

Chemical biology researchers to meet at Scientific Oktoberfest in München

Duties, role of clinical laboratory microbiologists could change significantly in the future

Study identifies genes never before linked to antibiotic resistance in enterococci

Mass. Eye and Ear receives NIAID grant to coordinate Harvard-wide Project on Antibiotic Resistance

Adding azithromycin to usual daily treatment for COPD reduces acute exacerbations by 27%

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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