Anticholinergic News and Research

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Researchers explore use of potentially inappropriate medications among frail nursing home residents

Medical experts know that older adults who have dementia or other mental health concerns that impact thinking or decision making should avoid certain "potentially inappropriate medications" (PIMs).

9 Aug 2017

Proton pump inhibitors do not increase risk for dementia or Alzheimer's disease

Proton pump inhibitors (PPIs) are medications used to treat digestive problems such as ulcers and reflux disease by reducing the body's production of the acid that helps us digest food.

22 Jun 2017

Anticholinergic drugs linked to increased rate of emergency department and hospital visits

Anticholinergic medications, a class of drugs very commonly used by older adults, are linked to an increased rate of emergency department and hospital utilization in the United States, according to an Indiana University Center for Aging Research, Indiana University Center for Health Innovation and Implementation Science, and Regenstrief Institute study of community-dwelling Americans age 65 and older.

21 Dec 2016

RTI extends research support to improve treatment for pelvic floor disorders in women

RTI International will continue supporting research efforts to improve clinical care for women with pelvic floor disorders as part of the Pelvic Floor Disorders Network.

6 Oct 2016

Long-term suppression of neurotransmitter acetylcholine may lead to dementia-like changes in the brain

A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life.

23 Jun 2016

Cairn launches non-invasive Gastric Emptying Breath Test for measuring rate of gastroparesis in adults

Cairn Diagnostics, formerly known as Advanced Breath Diagnostics (ABDiagnostics), has launched the 13C-Spirulina Gastric Emptying Breath Test (GEBT).

30 Mar 2016

Anticholinergic medications may not be best option for dementia patients in rehab facility

During rehabilitation following an acute hospital stay, medications that block neurotransmitters may be overprescribed to older patients suffering from delirium superimposed on dementia, according to health researchers.

29 Jan 2016

Anticholinergic medications do not affect cognitive performance in PD patients

Recent evidence has shown a greater risk of dementia, in particular Alzheimer's disease (AD), in individuals using anticholinergic medications regularly. These drugs are widely used by older adults to treat bladder dysfunction, mood, and pain, and many of them are available without prescription.

5 Jan 2016

Bridion injection approved to reverse effects of neuromuscular blocking drugs used during certain types of surgery

The U.S. Food and Drug Administration today approved Bridion (sugammadex) injection to reverse the effects of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide, which are used during certain types of surgery in adults.

16 Dec 2015

Researchers compare effectiveness of combination therapy for black patients with asthma

Among black adults with asthma treated with an inhaled corticosteroid, adding a long-acting beta-agonist did not improve the time to an asthma exacerbation compared with adding the anticholinergic tiotropium, according to a study in the October 27 issue of JAMA.

28 Oct 2015

Possible link discovered between common medications and falls in older men

Serious falls are more than twice as likely in older men who take medicines with anti-cholinergic properties - according to new research from the University of East Anglia.

29 Jul 2015

Anticholinergic medications associated with pneumonia risk in older people

Taking commonly used medications with anticholinergic effects is associated with a significantly higher risk for developing pneumonia in a study of more than 3,000 older Group Health patients living in the community--not in nursing homes.

3 Mar 2015

Researchers probe possibility of reversing medications' adverse cognitive effects

Whether the adverse cognitive effects of medications can be reversed is of significant importance to an aging population, their caregivers and their families, as well as to an overburdened health care system.

28 Jan 2015

Clinical markers help identify PD patients with cholinergic deficits

Assessing patients for clinical markers of cholinergic system denervation is viable and can help identify suitable individuals for trials of new anticholinergic drugs, researchers believe.

9 Dec 2014

Combination therapy beneficial for COPD patients

Research published in JAMA supports the use of a combination of long-acting β-agonists and inhaled corticosteroids in patients with chronic obstructive pulmonary disease.

31 Oct 2014

LABA-ICS combination therapy better than LABAs alone for COPD

Among older adults with chronic obstructive pulmonary disease (COPD), particularly those with asthma, newly prescribed long-acting beta-agonists (LABAs) and inhaled corticosteroid combination therapy, compared with newly prescribed LABAs alone, was associated with a lower risk of death or COPD hospitalization, according to a study in the September 17 issue of JAMA.

17 Sep 2014

Urge incontinence therapy may relieve stress incontinence

Anticholinergic medication appears to be effective as a treatment for stress and mixed urinary incontinence, results of a small clinical trial indicate.

15 Jul 2014

GSK reports positive results from Incruse Ellipta and Advair Diskus combination therapy in COPD patients

GlaxoSmithKline plc today presented data at the American Thoracic Society (ATS) from a late-stage clinical study.

20 May 2014

Ring pessary for OAB as effective as nonsurgical therapies

The use of a ring pessary appears to be an effective, well tolerated and inexpensive treatment for overactive bladder, say US researchers writing in International Urogynecology Journal.

19 May 2014

GSK, Theravance announce availability of Anoro Ellipta in the US for COPD treatment

GlaxoSmithKline plc and Theravance, Inc. today announced that Anoro Ellipta (umeclidinium and vilanterol inhalation powder), the first once-daily product approved in the US that combines two long-acting bronchodilators in a single inhaler for the maintenance treatment of chronic obstructive pulmonary disease (COPD), is now available to retail pharmacies in the US.

28 Apr 2014