Antidote News and Research

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JAPhA articles highlight role of pharmacists in controlling opioid crisis

Pharmacists often face serious challenges when trying to balance the needs of patients with chronic pain and preventing prescription drug misuse, abuse, and overdose.

7 Apr 2017

Researchers produce images that predate formation of beta-amyloid plaques in Alzheimer’s disease

Researchers at Lund University in Sweden have used the MAX IV synchrotron in Lund - the strongest of its kind in the world - to produce images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer's disease.

13 Mar 2017

UCI chemists develop cheap, effective way to neutralize deadly snake venom

Chemists at the University of California, Irvine have developed a way to neutralize deadly snake venom more cheaply and effectively than with traditional anti-venom -- an innovation that could spare millions of people the loss of life or limbs each year.

7 Mar 2017

EPFL scientists develop new computer model for better design of allosteric drugs

EPFL scientists have created a new computer model that can help better design of allosteric drugs, which control proteins "at a distance".

21 Feb 2017

UCLA director of mindfulness education discusses ways to unwind from election anxiety

One of the most contentious and anxiety-producing elections in recent U.S. history has ended.

9 Nov 2016

Protamine may be useful in developing new types of disinfectant solutions for contact lenses

Protamine -- a natural protein with a proven safety record -- may be useful in developing new types of disinfectant solutions for contact lenses, according to a study published in the November issue of Optometry and Vision Science, official journal of the American Academy of Optometry. The journal is published by Wolters Kluwer.

7 Nov 2016

New research project to explore how urban forestry affects health care spending

A hearty dose of Mother Nature may be an effective antidote for many physical and psychological ailments, several studies have suggested. However, no one has calculated how much green - as in dollars - nature's greenery saves on health care costs.

7 Oct 2016

Study sheds new light on role of Tau proteins in certain brain diseases

In a study published in the journal PNAS scientists of the German Center for Neurodegenerative Diseases present new findings on the role of the protein Tau in certain brain diseases.

7 Oct 2016

Scientists report early-stage development of potential nerve agent antidote

Nerve agents are molecular weapons that invade the body and sabotage part of the nervous system, causing horrific symptoms and sometimes death within minutes. Few antidotes exist, and those that do must be administered soon after an attack.

5 Oct 2016

Novel antidote effective in quickly reversing acute anticoagulant-related bleeding

A specially designed antidote to reverse acute, potentially life-threatening anticoagulant-related bleeding worked quickly, and was well-tolerated according to interim results of the ongoing ANNEXA-4 study.

30 Aug 2016

Genes of healthy leanness could lead to new approach to treating obesity-related diabetes

People with type 2 diabetes could be helped by the discovery of a gene linked to leanness.

7 Jun 2016

New drugs show promise as first antidote for radiation exposure

University of Virginia School of Medicine researchers have identified promising drugs that could lead to the first antidote for radiation exposure that might result from a dirty bomb terror attack or a nuclear accident such as Chernobyl.

2 Jun 2016

Antidote-resistant overdose patients may have received synthetic opioid W-18, suspects anesthesiologist

Months ago, ASRA member and anesthesiologist Anita Gupta, MD, suspected overdose patients had received heroin spiked with a synthetic opioid additive because they were not responding to the antidote, naloxone, routinely used by emergency workers.

25 May 2016

Easy, immediate access to effective antidotes could help reduce deaths from opioid overdose

Over the past 15 years, deaths caused by heroin and prescription opioid overdoses have quadrupled despite the existence of a highly effective antidote. The cover story in Chemical & Engineering News, the weekly news magazine of the American Chemical Society, explores what it might take to turn the tide.

19 May 2016

Study opens door for new opportunities in finding antidotes to nerve agent sarin

The nerve agent sarin causes a deadly overstimulation of the nervous system that can be stopped if treated with an antidote within minutes of poisoning. Today, a ground-breaking study has been published in PNAS, which in detail describes how such a drug works. Researchers at the Swedish Defence Research Agency, Umea University and in Germany are behind the study.

3 May 2016

Penn State researchers develop self-powered enzyme pumps

A new way to use the chemical reactions of certain enzymes to trigger self-powered mechanical movement has been developed by a team of researchers at Penn State University and the University of Pittsburgh. A paper describing the team's research, titled "Convective flow reversal in self-powered enzyme micropumps," is published this week in the journal Proceedings of the National Academy of Sciences.

27 Feb 2016

Johns Hopkins study shows high doses of cocaine kill brain cells

Working with mice, researchers at Johns Hopkins have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally digest their own insides. Their results, moreover, bring with them a possible antidote, an experimental compound dubbed CGP3466B.

19 Jan 2016

Scientists decipher details of cloaking proteins that protect the toxin that causes botulism

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory and collaborators at Stony Brook University and the Institute of Advanced Sciences in Dartmouth, Massachusetts, have discovered new details about how "cloaking" proteins protect the toxin that causes botulism, a fatal disease caused most commonly by consuming improperly canned foods.

7 Dec 2015

Sense oligonucleotide antidote reverses actions of antisense antithrombotic drug, prevents bleeding

Researchers from Isis Pharmaceuticals (Carlsbad, CA) and Prysis Biotechnologies (Pudong, Shanghai, China) have demonstrated proof-of-concept for using a sense oligonucleotide to undo the effects of an antisense drug, an antithrombotic agent in this novel study.

14 Oct 2015

Two new studies link Xarelto to stomach bleeds and eye hemorrhaging

MT Services LLC, a Lawsuit Settlement News Reporting Company which operates lawsuitsettlementnews.com, announced today that two new studies have shown a link between Xarelto and stomach bleeds and eye hemorrhaging.

23 Jul 2015