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Mathematical modeling proved critical in understanding latent stage of infections

Recurrent infection is a common feature of persistent viral diseases. It includes episodes of high viral production interspersed by periods of relative quiescence. These quiescent or silent stages are hard to study with experimental models. Mathematical analysis can help fill in the gaps.

3 Jun 2013

NewLink Genetics announces results from two clinical studies with indoximod

NewLink Genetics Corporation, an oncology-focused biopharmaceutical company specializing in immunotherapy, today announced results from two clinical studies with indoximod, an orally administered small molecule drug candidate that inhibits the IDO pathway.

3 Jun 2013

Research suggests medullary thymic epithelial cells may have evolved from cortical-thymic TECs

Medullary thymic epithelial cells (mTECs) allow the thymus to ensure that the body's T cells are able to distinguish between potentially harmful foreign antigens and those that are produced by the body itself.

3 Jun 2013

PharmAthene announces lifting of clinical hold on proposed SparVax Phase II study

PharmAthene, Inc., a biodefense company developing medical countermeasures against biological and chemical threats, announced today that the U.S. Food and Drug Administration has lifted the clinical hold previously placed on a proposed Phase II study of SparVax, a next generation recombinant anthrax vaccine.

31 May 2013

DCPrime completes DCP-001 Phase I/IIa study in patients with acute myeloid leukemia

Cancer vaccine company DCPrime today announced the successful completion of its Phase I/IIa study in acute myeloid leukemia.

28 May 2013

New study could help increase survival rates of people with colorectal tumours

Researchers from London's Kingston University have begun a two-year study which could help prolong the lives of people with colorectal tumours.

24 May 2013

Data shows frequent heartburn associated with cancers of the throat, vocal cord

Frequent heartburn was positively associated with cancers of the throat and vocal cord among nonsmokers and nondrinkers, and the use of antacids, but not prescription medications, had a protective effect, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

24 May 2013

Immune system attacks beneficial bacteria in several chronic human diseases

The human gut is loaded with commensal bacteria - "good" microbes that, among other functions, help the body digest food. The gastrointestinal tract contains literally trillions of such cells, and yet the immune system seemingly turns a blind eye. However, in several chronic human diseases such as inflammatory bowel disease, HIV/AIDS, cancer, cardiovascular disease, and diabetes, the immune system attacks these normally beneficial bacteria, resulting in chronic inflammation and contributing to disease progression.

23 May 2013

Johns Hopkins researchers find possible trigger of rheumatoid arthritis

In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe cases of the disease, the immune system makes a unique subset of antibodies that have a disease-promoting role.

23 May 2013

Cancer experts to discuss latest developments and implications of cell therapies in oncology

John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's top 50 cancer centers, will bring together leading cancer experts, for presentation and discussion of the latest developments and implications of cell therapy and interventional immunology in oncology, on Friday, June 7 from 7:00am to 1:30pm.

23 May 2013

UC Irvine chemists create new method to identify clinically usable markers for prostate cancer in urine

Early screening for prostate cancer could become as easy for men as personal pregnancy testing is for women, thanks to UC Irvine research published today in the Journal of the American Chemical Society.

23 May 2013

Scientists make important step forward in the quest to develop universal influenza vaccine

A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets.

23 May 2013

GUVAX reports successful results in phase I study of oral, Escherichia coli diarrhea vaccine

The University of Gothenburg Vaccine Research Institute (GUVAX) announces successful results in a placebo controlled phase I study of an oral, inactivated Escherichia coli diarrhea vaccine.

22 May 2013

iBio announces production of vaccine candidate for new H7N9 influenza virus

iBio, Inc. today announced the production of a vaccine candidate for the newly emerged H7N9 influenza virus by an independent third party laboratory using the iBioLaunch platform.

22 May 2013

Kidneys discarded for transplant can be used for manufacturing replacement organs, say researchers

Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too long without blood or oxygen. But, what if instead of being discarded, these organs could be "recycled" to help solve the critical shortage of donor organs?

21 May 2013

Pfizer halts Phase 3 open-label, two-arm study of lymphoma drug

Pfizer Inc. announced today the discontinuation of a Phase 3 randomized, open-label, two-arm study (B1931008) evaluating the safety and efficacy of the investigational compound inotuzumab ozogamicin in patients with relapsed or refractory CD22+ aggressive non-Hodgkin lymphoma who are not candidates for intensive high-dose chemotherapy.

From Pfizer, Inc. 21 May 2013

Groundbreaking germ-fighting vaccine research to be presented at National Biotechnology Conference

A novel vaccine study from South Dakota State University will headline the groundbreaking research that will be unveiled at the American Association of Pharmaceutical Scientists' National Biotechnology Conference.

21 May 2013

New diagnostic test for lymphatic filariasis

A new diagnostic test for a worm infection that can lead to severe enlargement and deformities of the legs and genitals is far more sensitive than the currently used test, according to results of a field study in Liberia, in West Africa, where the infection is endemic.

21 May 2013

New Kaiser Permanente study shows effectiveness of whole-cell pertussis vaccines

Whole-cell pertussis vaccines were more effective at protecting against pertussis than acellular pertussis vaccines during a large recent outbreak, according to a new Kaiser Permanente study published in Pediatrics.

20 May 2013

A*STAR, Cytos Biotechnology provide update on Phase 1 clinical trial of H1N1 influenza vaccine

Singapore's Agency for Science, Technology and Research and Switzerland's Cytos Biotechnology AG today announced that the first healthy volunteer has been dosed in a Phase 1 clinical trial with their H1N1 influenza vaccine candidate based on Cytos' proprietary bacteriophage Qbeta virus-like particle technology.

17 May 2013

Antigen News and Research

Mathematical modeling proved critical in understanding latent stage of infections

NewLink Genetics announces results from two clinical studies with indoximod

Research suggests medullary thymic epithelial cells may have evolved from cortical-thymic TECs

PharmAthene announces lifting of clinical hold on proposed SparVax Phase II study

DCPrime completes DCP-001 Phase I/IIa study in patients with acute myeloid leukemia

New study could help increase survival rates of people with colorectal tumours

Data shows frequent heartburn associated with cancers of the throat, vocal cord

Immune system attacks beneficial bacteria in several chronic human diseases

Johns Hopkins researchers find possible trigger of rheumatoid arthritis

Cancer experts to discuss latest developments and implications of cell therapies in oncology

UC Irvine chemists create new method to identify clinically usable markers for prostate cancer in urine

Scientists make important step forward in the quest to develop universal influenza vaccine

GUVAX reports successful results in phase I study of oral, Escherichia coli diarrhea vaccine

iBio announces production of vaccine candidate for new H7N9 influenza virus

Kidneys discarded for transplant can be used for manufacturing replacement organs, say researchers

Pfizer halts Phase 3 open-label, two-arm study of lymphoma drug

Groundbreaking germ-fighting vaccine research to be presented at National Biotechnology Conference

New diagnostic test for lymphatic filariasis

New Kaiser Permanente study shows effectiveness of whole-cell pertussis vaccines

A*STAR, Cytos Biotechnology provide update on Phase 1 clinical trial of H1N1 influenza vaccine

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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