Aortic Stenosis News and Research

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High-risk surgical patients with severe aortic stenosis can benefit from new TAVR system

The Portico IDE study found that 30-day safety and one-year effectiveness outcomes of a novel self-expanding transcatheter aortic valve replacement (TAVR) system for patients with severe aortic stenosis (AS) at high or extreme-risk for surgery was noninferior to contemporary FDA-approved TAVR systems available in the United States.

30 Sep 2019

Mutated ciliary genes tied to heart valve birth defect

The heart pumps blood throughout the body to provide the needed oxygen and nutrients. In the heart, blood flows to get oxygen from the lungs to deliver to the cells. Some of the most important structures in the heart are the valves, because they prevent the backflow of blood, avoiding the mixture of oxygenated blood with the ones that still need to be oxygenated.

17 Sep 2019

Latest advances in cardiovascular medicine to be unveiled

Journalists looking to stay abreast of the hottest research in cardiology are invited to follow the press program for ESC Congress 2019, this year held together with the World Congress of Cardiology.

13 Aug 2019

Catheter-based valve replacement procedure safe for patients with common heart defect

A new analysis conducted by investigators at the Cedars-Sinai Smidt Heart Institute shows for the first time that patients with a common heart defect who undergo catheter-based valve replacement procedures have the same survival and complication rates as patients without the defect who undergo the same procedure.

12 Jun 2019

Study examines the effects of TAVR with balloon-expandable valve for low-risk patients

For patients with aortic stenosis that cannot be treated with medication, surgical and transcatheter aortic valve replacement can offer effective treatment.

6 May 2019

Early treatment of patients with severe aortic stenosis may be better than watch-and-wait approach

Patients with severe aortic stenosis who have no symptoms may benefit more from an aggressive strategy of early valve replacement than from a conservative watch-and-wait approach, according to new research published today online in The Annals of Thoracic Surgery.

27 Mar 2019

TAVR procedure safe in patients with unusual valve anatomy

Compared with patients who had a typical tricuspid aortic valve, patients with a more unusual bicuspid aortic valve had a similar rate of death but a higher likelihood of stroke after undergoing a procedure to replace the valve by threading surgical equipment through an artery, according to research presented at the American College of Cardiology's 68th Annual Scientific Session.

18 Mar 2019

Study finds TAVR to be as good as open-heart surgery for patients at low surgical risk

A new trial comparing self-expanding transcatheter aortic valve replacement (TAVR) to standard open-heart surgery for valve replacement—this time in patients with severe aortic stenosis who are considered low surgical risk—found no difference in the combined rate of disabling stroke or death from any cause at two years.

18 Mar 2019

Big-data analysis finds new link between popular arthritis drug and heart valve calcification

A well-known, four-year study found popular arthritis drug Celebrex no more dangerous for the heart than older drugs in its same classification - commonly called NSAIDs.

23 Feb 2019

Researcher explore why some patients recover quickly after surgery while others don't

Why do some patients recover quickly after surgery, while others don't? That is an important question when treating older frail patients suffering from aortic stenosis. Lead author Dae Hyun Kim, M.D., M.P.H., Sc.D., and principle investigator Director Lewis A. Lipsitz in the Marcus Institute for Aging Research at Hebrew SeniorLife explore this question in a paper published today in the Journal of the American Medical Association Internal Medicine.

5 Feb 2019

Gerontologists assess change in patients' functional status after valve replacement procedure

Affecting an estimated one in eight people older than 75, aortic valve stenosis - a narrowing of the heart's main artery - makes the heart work harder to supply the body with blood, potentially limiting patient's activity levels an quality of life. Ultimately, aortic stenosis can lead to stroke, arrhythmia, heart failure and death.

5 Feb 2019

Thubrikar announces first human implant of Optimum TAV using their TAVI system

Thubrikar Aortic Valve, Inc., a privately held medical device company, today announced the first human implant of the Optimum TAV using their transcatheter aortic valve implantation system.

9 Jan 2019

Individual cells within the same heart cope differently with high blood pressure, study shows

Individual cells within the same heart cope differently with high blood pressure, according to a study in human cells and mice by a team of cardiologists and computational biologists at the University of Tokyo.

30 Oct 2018

Researchers explore whether open heart surgery affects cognitive abilities

Most people who need open heart surgery to repair damaged heart valves are aged 65 or older. The American Heart Association estimates that nearly 8 million people have had heart surgeries.

12 Oct 2018

Most patients who underwent transcatheter valve replacement experience prosthesis-patient mismatch

In the largest multi-institutional study to date, led by researchers from Penn Medicine, the team found that among patients who underwent a transcatheter aortic valve replacement, a high number experienced severe and moderate cases of prosthesis-patient mismatch--meaning the implanted heart valve is too small for the patient which can lead to inadequate blood flow.

24 Sep 2018

Using speckle-tracking echocardiography to evaluate cardiac diseases

In the current issue of Cardiovascular Innovations and Applications (Volume3, Number 2, 2018, pp. 237-250(14); DOI: https://doi.org/10.15212/CVIA.2017.0040 Randy R. Jeffrey, Robert F. Hamburger, Janelle Gooden-Ebanks and John W. Petersen from the Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA consider impaired longitudinal strain as a common deficit in various cardiac diseases.

11 Sep 2018

Clinical trial provides 'strong signal' that TAVR is safe for patients with low surgical risk

Results of a clinical trial using transcatheter aortic valve replacement provided a "strong signal" that it is safe for patients with low surgical risk, potentially helping to open the way for broader use of the minimally invasive procedure, also known as TAVR.

30 Aug 2018

Hospitals battle for control over fast-growing heart-valve procedure

When Medicare in 2011 agreed to pay for a revolutionary procedure to replace leaky heart valves by snaking a synthetic replacement up through blood vessels, the goal was to offer relief to the tens of thousands of patients too frail to endure open-heart surgery, the gold standard.

17 Aug 2018

Mono-antiplatelet therapy after aortic heart valve replacements may work as well as two drugs

Current treatment guidelines say patients who undergo minimally invasive aortic heart valve replacements should receive two antiplatelet drugs to reduce the risk of dangerous blood clots.

14 Aug 2018

Naturally occurring antibody can block inflammation in mice, finds study

Researchers at University of California San Diego School of Medicine discovered that they can block inflammation in mice with a naturally occurring antibody that binds oxidized phospholipids, molecules on cell surfaces that get modified by inflammation.

7 Jun 2018