Apolipoprotein News and Research

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Barley products lower levels of two types of bad cholesterol linked to cardiovascular risk

Eating barley or foods containing barley significantly reduced levels of two types of "bad cholesterol" associated with cardiovascular risk, a St. Michael's Hospital research paper has found.

8 Jun 2016

Cerebral microbleeds warn of dementia risk

A high cerebral microbleed count increases an individual's risk of cognitive deterioration and dementia, study results indicate.

8 Jun 2016

Study finds beer consumption may protect against Aβ aggregation in the brain

While most people will agree that excessive consumption of alcohol can have a detrimental effect on the brain, there is less agreement regarding the effects of light or moderate drinking.

2 Jun 2016

Certain genetic markers linked with depression can also predict who may benefit from exercise

Call it personalized medicine for depression -- but the prescription in this case is exercise, which University of Florida Health researchers have found helps people with certain genetic traits.

28 Apr 2016

$New sensitive detection method could help measure subfractions of HDL$

New sensitive detection method could help measure subfractions of HDL

High-density lipoprotein (HDL) is often referred to as good cholesterol: high levels of HDL are associated with lower risk of cardiovascular disease. But many clinical outcome trials for drugs that raise HDL levels have failed to show significant benefits for trial participants.

12 Apr 2016

Study: High-cholesterol diet or eating eggs do not increase risk of cardiovascular diseases

A new study from the University of Eastern Finland shows that a relatively high intake of dietary cholesterol, or eating one egg every day, are not associated with an elevated risk of incident coronary heart disease. Furthermore, no association was found among those with the APOE4 phenotype, which affects cholesterol metabolism and is common among the Finnish population.

11 Feb 2016

Study provides new insight into complex interchange that can raise blood levels of fat in type 1 diabetes

Researchers have new insight into the complex interchange that can raise blood levels of unhealthy lipids, or fat, in type 1 diabetes, and early evidence that a drug under study to block cancer cell growth can restore healthier levels.

8 Feb 2016

Continuing weight loss from midlife predicts MCI risk

Increasing weight loss from middle age through the later stages of life may be an indicator of mild cognitive impairment, suggest study findings.

2 Feb 2016

Does cancer affect memory? An interview with Associate Professor Janette Vardy

The study evaluated cognitive function in patients with colorectal cancer. It characterized the incidence and severity of cognitive impairment in people with colorectal cancer (CRC) compared to healthy controls.

7 Jan 2016

Cholesterol essential for health, but also plays key role in longevity

Animals from tiny worms to human beings have a love-hate relationship with fats and lipids. Cholesterol is a famous example of how they are both essential for health and often have a role in death.

23 Dec 2015

Researchers find molecular mechanism that may be responsible for development of amyloidoses

A team of local researchers has proposed a molecular mechanism that may be responsible for the development of life-threatening diseases called amyloidoses. The best known of such diseases is Alzheimer's disease (AD), but there are many others that are receiving increased scrutiny, in part because of mounting evidence linking them to atherosclerosis and aging.

13 Nov 2015

Mayo Clinic's Florida campus awarded NIH grant to identify vascular risk factors in aging and dementia

Mayo Clinic's Florida campus was awarded a $5.3 million grant from the National Institutes of Health to identify vascular risk factors in aging and dementia, and translate that knowledge into studying potential targets for treatment.

12 Nov 2015

Meta-analysis supports that intake of tree nuts lowers risk of cardiovascular disease

In a study published yesterday in the American Journal of Clinical Nutrition*, researchers performed a systematic review and meta-analysis of controlled trials to investigate the effects of tree nuts (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts) on blood lipids, lipoproteins, blood pressure and inflammation in adults 18 years and older without prevalent cardiovascular disease (CVD).

12 Nov 2015

ApoE4-carrying men with Alzheimer's disease at risk of brain bleeds

A common genetic variation, ApoE4, linked to Alzheimer's disease greatly raises the likelihood of tiny brain bleeds in some men, scientists have found.

12 Nov 2015

APOE ε4 predicts risk of future depression

One of the most powerful predictors in neuropsychiatry is the epsilon 4 (ε4) allele of the apolipoprotein gene (APOE).

3 Nov 2015

Changes in lifestyle could reduce Alzheimer's disease risk

Changes in lifestyle could reduce the risk of developing Alzheimer's disease. That was the conclusion of a study conducted by researchers of Heidelberg University's Network Aging Research, who examined the data from two independent epidemiological studies. Carriers of the ApoE4 genetic risk factor for Alzheimer's may be able to reduce their increased risk of cognitive decline by reducing their cholesterol level, especially if they also suffer from cardiovascular disease.

27 Oct 2015

New study heightens concerns over detrimental impact of air pollution on gene associated with AD risk

A new study by researchers at the Universities of Montana, Valle de México, Boise State, and North Carolina, the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Instituto Nacional de Pediatría, and Centro Médico Cozumel heightens concerns over the detrimental impact of air pollution on hippocampal metabolites as early markers of neurodegeneration in young urbanites carrying an allele 4 of the apolipoprotein E gene (APOE).

26 Sep 2015

NUS researchers develop new technique to observe nano-bio interactions

Researchers at the National University of Singapore have developed a technique to observe, in real time, how individual blood components interact and modify advanced nanoparticle therapeutics.

16 Sep 2015

Researchers take new line of approach to combat Alzheimer's disease

Today, more than 5.1 million Americans live with Alzheimer's disease, a devastating type of dementia that plagues memory and thinking. That number is expected to triple in the coming decades. Moreover, according to a 2012 survey, Americans fear Alzheimer's more than any other disease.

10 Sep 2015

Study sheds further light on the way APOL1 protein kills trypanosmoe

The African trypanosome Trypanosoma brucei is a blood parasite capable of infecting many mammals. Humans are provided with natural immunity against infection through the activity of the protein apolipoprotein L1 (APOL1): captured via endocytosis, APOL1 forms pores in the lysosomal membrane, leading to the death of the trypanosome.

27 Aug 2015

Apolipoprotein News and Research

Barley products lower levels of two types of bad cholesterol linked to cardiovascular risk

Cerebral microbleeds warn of dementia risk

Study finds beer consumption may protect against Aβ aggregation in the brain

Certain genetic markers linked with depression can also predict who may benefit from exercise

New sensitive detection method could help measure subfractions of HDL

Study: High-cholesterol diet or eating eggs do not increase risk of cardiovascular diseases

Study provides new insight into complex interchange that can raise blood levels of fat in type 1 diabetes

Continuing weight loss from midlife predicts MCI risk

Does cancer affect memory? An interview with Associate Professor Janette Vardy

Cholesterol essential for health, but also plays key role in longevity

Researchers find molecular mechanism that may be responsible for development of amyloidoses

Mayo Clinic's Florida campus awarded NIH grant to identify vascular risk factors in aging and dementia

Meta-analysis supports that intake of tree nuts lowers risk of cardiovascular disease

ApoE4-carrying men with Alzheimer's disease at risk of brain bleeds

APOE ε4 predicts risk of future depression

Changes in lifestyle could reduce Alzheimer's disease risk

New study heightens concerns over detrimental impact of air pollution on gene associated with AD risk

NUS researchers develop new technique to observe nano-bio interactions

Researchers take new line of approach to combat Alzheimer's disease

Study sheds further light on the way APOL1 protein kills trypanosmoe

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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