Artemisinin is a drug used to treat multi-drug resistant strains of falciparum malaria. The compound (a sesquiterpene lactone) is isolated from the plant Artemisia annua. Not all plants of this species contain artemisinin.
Indiana University School of Medicine researchers have identified a way to block the ability of parasites that cause malaria to shield themselves against drug treatments in infected mice--a finding that could lead to the development of new approaches to combat this deadly disease in humans.
A new analysis of all relevant previously published clinical data shows how parasites causing malaria become resistant to a commonly used treatment for malaria in travellers.
The Global Health Innovative Technology Fund, a unique Japanese public-private partnership formed to battle infectious diseases around the globe, today announced US$16.7 million to support development of new compounds for fighting malaria and tuberculosis, a leishmaniasis vaccine and drug, and a treatment for a long-ignored flesh-eating infection.
The spread of a single multidrug resistant malaria parasite strain in Vietnam is cause for alarm say researchers.
Texas Biomedical Research Institute researchers, Dr. Tim Anderson and Dr. Ian Cheeseman, have partnered with researchers at the University of Notre Dame and the Center for Infectious Disease Research in Seattle to pursue studies in drug resistant malaria.
Artemisinin, a potent anti-malarial drug, has been widely hailed as a promising alternative cancer treatment. Scientists from the National University of Singapore recently showed that its anti-cancer properties could be enhanced by 10 folds when used in combination with Aminolaevulinic acid, a photosensitizer or a drug which, upon exposure to light, leads to generation of free radicals that can kill cells.
Compared to smallpox or typhoid, malaria is proving one of the most challenging human diseases to eradicate - and so remains a real and constant danger to nearly half the world's population.
The National Institutes of Health has renewed a major grant that funds a University of Washington-led research center to understand malaria in India.
Malaria is more common and severe in pregnant women, increasing their risk of miscarriage and other adverse outcomes. The adverse consequences of malaria in pregnancy require prompt, safe, and effective treatment.
When the standard malaria medications failed to help 18 critically ill patients, the attending physician in a Congo clinic acted under the "compassionate use" doctrine and prescribed a not-yet-approved malaria therapy made only from the dried leaves of the Artemisia annua plant.
Since the ancient times, mankind has used plants to treat diseases. An example is the plant Artemisia annua, used for over 2,000 years in traditional Chinese medicine to treat intermittent fevers.
Researchers at Cardiff University have devised a new way of creating a drug commonly used as the first line of defence against malaria around the world.
Malaria infections may soon be treated much more efficiently than they are at present. Researchers at the Universities of Bayreuth and Jerusalem have developed a novel drug release procedure for this purpose.
The iron-containing molecule heme is necessary for life. Cells require heme to perform the chemical reactions that produce energy, among other critical tasks.
A centuries-old herbal medicine, discovered by Chinese scientists and used to effectively treat malaria, has been found to potentially aid in the treatment of tuberculosis and may slow the evolution of drug resistance.
The Monell Center announced today that it has received a $345,000 grant from the Bill & Melinda Gates Foundation. The grant supports an innovative global health research project titled, "Developing Novel Pediatric Formulation Technologies for Global Health: Human Taste Assays."
Malaria is one of the leading causes of mortality in developing countries – last year killing more than 400,000 people. Researchers worldwide have found the solution for drug discovery could lie in open, “crowd-sourced” science.
Malaria remains one of the world's leading causes of mortality in developing countries. Last year alone, it killed more than 400,000 people, mostly young children.
For chemists like Sarah Reisman, professor of chemistry at Caltech, synthesizing molecules is like designing your own jigsaw puzzle. You know what the solved puzzle looks like--the molecule--and your job is to figure out the best pieces to use to put it together.
Malaria researchers at The Australian National University have found one of the malaria parasite's best weapons against drug treatments turns out to be an Achilles' heel, which could be exploited to cure the deadly disease.