Autoimmunity News and Research

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Autoimmune Disease is a condition in which the body recognizes its own tissues as foreign and directs an immune response against them.

New murine model sheds light on anti-MDA5 antibody-positive dermatomyositis

Some diseases involve autoimmune reactions, when the body begins to attack its own cells and proteins.

13 Apr 2024

Systemic Inflammation Index: A new hope for autoimmune disease management

A routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of debilitating autoimmune diseases.

2 Apr 2024

Unraveling epigenetic contributions to autoimmune skin diseases

The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein.

25 Mar 2024

Researchers identify T-cell subsets as effective therapeutic target for preventing transplant rejection

Houston Methodist researchers identified a troublesome subset of T-cells in transplant recipients that may be a more effective therapeutic target for preventing transplant rejection in patients.

14 Mar 2024

LAG-3 protein structure may be the key to unlocking new cancer treatments

A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable the development of new cancer treatments.

11 Mar 2024

Study reveals key mechanism of PD-1 function

Insights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict its action can potentially be strengthened to improve their anticancer effect, a new study shows.

9 Mar 2024

Pregnant women with autoimmune conditions at a greater risk of developing adverse pregnancy outcomes, study suggests

Researchers analyzed systematic reviews conducted on the association between autoimmune diseases and pregnancy outcomes.

8 Mar 2024

Is there a higher risk of depression among specific populations of patients with rheumatoid arthritis?

Researchers assessed the risk of depression following the diagnosis of rheumatoid arthritis (RA).

8 Mar 2024

Understanding long COVID: A call for better diagnosis and treatment

A recent review in Nature Reviews Microbiology summarizes the complex mechanisms, significant impacts, and the urgent need for enhanced diagnostics and treatments for long COVID, affecting over 65 million people globally with diverse, debilitating symptoms and systemic health issues.

7 Mar 2024

New scSNV-seq technique unveils genetic drivers of diseases like cancer and Alzheimer's

Scientists have developed a new screening tool to uncover how genetic changes affect gene activity and can lead to diseases such as cancer, autoimmunity, neurodegeneration and cardiovascular disease. This new tool enables the investigation of thousands of DNA mutations identified by genetic studies in one experiment, guiding the development of advanced diagnostics and treatments.

4 Mar 2024

Unlocking the secrets of T follicular helper cells for better treatment strategies

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.

1 Mar 2024

Can dietary patterns impact stomach cancer risk?

Eating patterns and indices related to gastric cancer and explored their association with stomach cancer risk.

22 Feb 2024

Mediterranean diet hailed for heart health benefits in women, study finds

Study highlights the Mediterranean diet's cardioprotective benefits for females, emphasizing its role in improving lipid profiles, blood pressure, and reducing cardiovascular disease risks, with a call for more female-focused research.

21 Feb 2024

ANU discovery provides new insight into how the immune system fights malaria

Researchers from The Australian National University (ANU) have discovered a previously unknown ability of a group of immune system cells, known as Atypical B cells (ABCs), to fight infectious diseases such as malaria.

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

World-first discovery offers potential cure for lupus

Australian researchers have worked out how to fix a defect that causes lupus, and hope their world-first discovery will offer effective long-term treatment.

6 Feb 2024

Xist lncRNA identified as key trigger in female-biased autoimmune diseases

Researchers uncover that the Xist ribonucleoprotein complex, unique to females, is a key driver of sex-biased autoimmunity, offering new insights into autoimmune disorders' higher prevalence in women.

4 Feb 2024

X-chromosome inactivation and its role in autoimmune susceptibility in females

Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.

1 Feb 2024

Study finds patients with long COVID exhibit complement dysregulation with signs of thromboinflammation

Researchers explore inflammatory signatures restricted to patients with active post-acute COVID-19 sequelae.

23 Jan 2024

New biomarkers could help detect lupus nephritis earlier

New biomarkers with improved diagnostic performance for early detection of lupus nephritis have been discovered in the University of Houston lab of Chandra Mohan, a pioneer in lupus research.

22 Jan 2024