Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Potential SARS-CoV-2 antiviral: Ionophore X-206 found to inhibit viral replication in cell cultures

In a study published in the journal Antiviral Research, researchers from Aarhus University, Denmark, report on their tests on different polyether ionophores to inhibit SARS-CoV-2 in vitro.

1 Dec 2020

New reviews provide timely updates for scholars, professionals focused on antimicrobial research

The initial chapter of 'Anti-infective Research and Development: Updates on Infection Mechanisms and Treatments' covers the mode of action of natural antimycobacterial compounds such as nordihydroguaiaretic acid, α-mangostin and allicin, as well as antimicrobial peptides and their role in the innate and adaptive immune response leading to the decrease of microbial resistance.

1 Dec 2020

Could the keto diet help prevent or mitigate severe COVID-19?

A new study published in the journal of Translational Medicine reports that the ketogenic diet (KD) may be useful in this area, with its track history of effectual reduction of fat mass, anti-inflammatory and immunomodulatory effects, and consequent improvement of cardiovascular health.

30 Nov 2020

Early, late stages of neurodegeneration are distinct, finds study

Rice University biochemists Michael Stern and James McNew have studied how neurodegeneration kills cells.

23 Nov 2020

COVID-19 potentially has negative impacts on male fertility

A review recently published in the Journal of Medical Virology has discussed some of the effects that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – may have on male fertility.

22 Nov 2020

Build-up of cellular 'trash' in the brain can cause neurodegeneration, death

A little mess never killed anyone, right? Wrong. Researchers at Tokyo Medical and Dental University (TMDU) have recently shown that a build-up of cellular "trash" in the brain can actually cause neurodegeneration, and even death.

19 Nov 2020

Researchers gain novel insights into the role of autophagy in neurons

It appears that autophagy protects our neurons in the brain, but evidently for entirely different reasons than previously assumed, as researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Charité in Berlin have now shown.

5 Nov 2020

Dietary restriction effective in reducing the odds of developing liver cancer from fatty liver

Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan.

29 Oct 2020

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

By leveraging nucleotide triphosphate analog-induced cell death, Chinese researchers unveiled genes that affect the import, export, and metabolism of pervasively used antiviral drugs in the treatment of coronavirus disease (COVID-19). This exciting study is currently available on the bioRxiv* preprint server.

28 Oct 2020

Grant programs will provide $2.2 million to support biomedical research on healthy aging

The Glenn Foundation for Medical Research and the American Federation for Aging Research announce the 2020 recipients of three grant programs: the Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty, the Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research, and the Glenn Foundation for Medical Research Breakthroughs in Gerontology Awards.

28 Oct 2020

Research on autophagy and coronavirus, implicates ULK1

Researchers from the University of British Columbia have discovered that the betacoronavirus-encoded papain-like protease disrupts autophagy, partly by targeting ULK1. Their work is reported on the preprint server bioRxiv* in October 2020.

27 Oct 2020

Dietary supplement represents an innovative strategy to help in the fight against SARS-CoV-2

SPIN (SPermidin and eugenol INtegrator for contrasting incidence of coronavirus in EU population) is a European project powered by EIT Food that is currently developing a dietary supplement supporting the function of the immune system in the fight against SARS-CoV-2 infections in population at high risk.

21 Oct 2020

Study provides possible explanation for progressive course of multiple sclerosis in mice

People with multiple sclerosis gradually develop increasing functional impairment. Researchers at Karolinska Institutet in Sweden have now found a possible explanation for the progressive course of the disease in mice and how it can be reversed.

16 Oct 2020

Study offers renewed hope for children suffering from myofibrillar myopathies

Stephen Greenspan and Laura Zah were devastated when they learned their son Alexander had a rare genetic mutation, which causes a deadly neuromuscular disease with no known treatment or cure.

14 Oct 2020

Genoscience Pharma's GNS561 shows potential against SARS-CoV-2 in vitro

A new study published on the preprint server bioRxiv in October 2020 shows that a combination of a new compound GNS561 and remdesivir act synergistically against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This suggests that autophagy inhibitors could be an alternative strategy for SARS-CoV-2 infection.

12 Oct 2020

Integrin b3 and ACE2 linked by short linear motifs enabling endocytosis and autophagy of SARS-CoV-2

A new study by Uppsala University researchers published on the preprint server bioRxiv in October 2020 shows possible links between the angiotensin-converting enzyme 2 (ACE2) host cell receptors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the entry of viral particles into the cell via endocytosis and autophagy.

12 Oct 2020

Enzyme SSH1 impairs the disposal of damaged tau and neurotoxic mitochondria

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

12 Oct 2020

Blocking the self-destruction process of enzymes can mitigate age-related diseases

Stopping the cannibalistic behavior of a well-studied enzyme could be the key to new drugs to fight age-related diseases, according to a new study published online in Nature Cell Biology.

30 Sep 2020

Discovery of specific kinase as a novel drug target against SARS-CoV-2 and other coronaviruses

By using a modern genome-wide knockout approach to single out coronavirus host factors in human cells, researchers from Rega Institute in Belgium discovered a potential new target that might be exploited for developing drugs against the ongoing coronavirus disease (COVID-19) pandemic, but also future outbreaks of highly pathogenic coronaviruses

29 Sep 2020

Study shows how Zika virus degrades key protein involved in neurological growth

In a study published in Autophagy, researchers at the University of Maryland (UMD) shed new light on how Zika virus hijacks our own cellular machinery to break down a protein that is essential for neurological development and cellular communication, getting it to "eat itself."

29 Sep 2020

Autophagy News and Research

Further Reading

Potential SARS-CoV-2 antiviral: Ionophore X-206 found to inhibit viral replication in cell cultures

New reviews provide timely updates for scholars, professionals focused on antimicrobial research

Could the keto diet help prevent or mitigate severe COVID-19?

Early, late stages of neurodegeneration are distinct, finds study

COVID-19 potentially has negative impacts on male fertility

Build-up of cellular 'trash' in the brain can cause neurodegeneration, death

Researchers gain novel insights into the role of autophagy in neurons

Dietary restriction effective in reducing the odds of developing liver cancer from fatty liver

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

Grant programs will provide $2.2 million to support biomedical research on healthy aging

Research on autophagy and coronavirus, implicates ULK1

Dietary supplement represents an innovative strategy to help in the fight against SARS-CoV-2

Study provides possible explanation for progressive course of multiple sclerosis in mice

Study offers renewed hope for children suffering from myofibrillar myopathies

Genoscience Pharma's GNS561 shows potential against SARS-CoV-2 in vitro

Integrin b3 and ACE2 linked by short linear motifs enabling endocytosis and autophagy of SARS-CoV-2

Enzyme SSH1 impairs the disposal of damaged tau and neurotoxic mitochondria

Blocking the self-destruction process of enzymes can mitigate age-related diseases

Discovery of specific kinase as a novel drug target against SARS-CoV-2 and other coronaviruses

Study shows how Zika virus degrades key protein involved in neurological growth

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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