Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

NEMO protein's crucial role in Parkinson's defense revealed

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

19 Dec 2023

D-mannose could improve age-associated urinary tract dysfunction and help reduce UTIs

Aging poses a number of challenges to the body's well-being, one of the most important being an increased susceptibility to multiple diseases, including urinary tract infections (UTIs).

14 Dec 2023

Researchers develop novel exosome-based drug delivery system to treat Alzheimer's disease

A research team led by Hong Kong Baptist University (HKBU) has developed a novel drug delivery system for Alzheimer’s disease (AD).

11 Dec 2023

Scientists uncover new mechanism by which leukemia cells exploit cellular recycling process

In a recent study, scientists led by Professor Stefan Müller from Goethe University's Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML.

4 Dec 2023

The effects of vitamin K on bone health

Existing scientific data on the effects of vitamin K (VK) on bone health and elucidated the underlying mechanisms.

30 Nov 2023

Parkinson's disease a potential pathogenetic factor for coronary artery disease and stroke, study suggests

Researchers performed a two-sample Mendelian randomization (MR) analysis to explore causal associations between Parkinson's disease (PD) and cardio-cerebrovascular diseases.

24 Nov 2023

New insights into how SARS-CoV-2 evades our immune system

This review in Cellular and Molecular Immunology delves into the innate immune response to SARS-CoV-2, exploring how the virus evades immunity and the potential role of innate immunity in long-COVID and vaccine responses, shedding light on future therapeutic strategies.

23 Nov 2023

Microautophagy plays crucial role in lysosome repair, promoting healthy aging

To age or not to age! How does aging affect organisms on a cellular level? What mechanisms help cells survive self-inflicted or external harm? It is known that lysosomes-;critically important cellular structures-;are crucial for digesting damaged cellular components and pathogens, and maintain stability within cells and tissues.

21 Nov 2023

New insights into the pathogenesis of chronic liver diseases

Fatty liver diseases (FLD) have become a significant health concern worldwide, affecting millions. The two most common types of FLD are non-alcoholic fatty liver disease (NAFLD) and alcoholic-associated liver disease (ALD). NAFLD is associated with obesity, insulin resistance, and metabolic syndrome, while ALD is caused by excessive alcohol consumption.

7 Nov 2023

Metabolic increase in the hippocampus is early sign of Alzheimer's disease, study finds

An early phase in the process of developing Alzheimer's disease is a metabolic increase in a part of the brain called the hippocampus, report researchers from Karolinska Institutet in a study published in Molecular Psychiatry.

31 Oct 2023

How one gene shakes up our understanding of male infertility

The study investigates the role of the ACTL7B gene in sperm formation using genetically modified mice and finds that deficiencies in this gene lead to failed spermatogenesis and structural sperm abnormalities. Given the gene's similarity in humans, the findings suggest ACTL7B could serve as a potential biomarker for male infertility.

31 Oct 2023

Oral pathogen linked to increased risk of heart rupture after heart attack

Researchers from Tokyo Medical and Dental University(TMDU) find that a periodontal pathogen, Porphyromonas gingivalis, inhibits autophagosome–lysosome fusion, and can therefore worsen cardiac remodeling and cause cardiac rupture after myocardial infarction.

19 Oct 2023

Can coffee silverskin be used to prevent aging?

The anti-aging properties of coffee silverskin extracts (CSE).

13 Oct 2023

Unveiling the role of astrocyte-derived LCN2 in neurodegenerative disease progression

Researchers reviewed existing data on the neurodegenerative effects of astrocyte-derived lipocalin-2 (LCN-2).

4 Oct 2023

Identification of Alzheimer's disease-associated micro-RNA biomarkers through network-based analysis

Micro-ribonucleic acids (miRNAs) linked to cognition and Alzheimer's disease (AD).

3 Oct 2023

Evidence reveals ferroptosis's critical role in male reproductive health

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2 Oct 2023

Discovery lead to better methods for reducing mosquito-to-human transmission of deadly viruses

Researchers from the Johns Hopkins Malaria Research Institute at the Johns Hopkins Bloomberg School of Public Health have made an important finding about Aedes aegypti mosquitoes-;one that could one day lead to better methods for reducing the mosquito-to-human transmission of dengue, yellow fever, Zika, and other harmful and sometimes deadly viruses.

22 Sep 2023

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