Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Study provides vital information to develop successful PI5P4K inhibitors for p53-mutant cancers

One major hallmark of cancer cells is their ability to adapt to stressful conditions such as nutrient deprivation. Rapidly growing tumor cells must compete for the ever-diminishing supply of nutrients in the surrounding environment to survive and proliferate. Targeting these adaptive mechanisms represents a promising approach for cancer therapeutics.

3 May 2018

Researchers discover glutamine-dependent activation of cell growth and autophagy

The human body consists of about 35 trillion cells, so it could be said that overall body growth is the growth of individual cells.

3 May 2018

Innovative research could lead to new ways to treat, prevent cancer

Research into cancer can provide new insight into how this disease works and how it can be stopped. The Experimental Biology 2018 meeting will showcase innovative research that could lead to new ways to treat and prevent cancer.

23 Apr 2018

Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens

Existing microscopy-based methods of detecting apoptosis, such as TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling), have limited quantitative capabilities due to insufficient signal-to-noise ratios.

19 Apr 2018

Finding ways to reverse obesity’s lingering, pro-cancer effects

Like exposure to too much sun and drinking alcohol, obesity is a risk factor for cancer. Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center are working to be a part of the solution -- they want to find ways to reverse obesity-linked biological changes in the body that are associated with cancer growth.

16 Apr 2018

Researchers find possible therapeutic strategy to block self-eating in pancreatic cancers

To get the extra energy they need to fuel their uncontrolled growth, cancer cells break down some of their own parts for fuel - a process known as autophagy, or "self-eating."

13 Apr 2018

Dietary fats play varied roles in disease

This month's issue of the Journal of Lipid Research features studies examining how fats in the diet affect health, including whether the ketogenic diet is a reasonable cancer therapy; how the type of unsaturated fats in a mouse's chow affects inflammation; and how cells respond to nutrient signals.

12 Apr 2018

Aberrant protein prevents self-cleaning of nerve cells in ALS

Scientists have discovered that TDP-43 interferes with lysosomal pathways responsible for its clearance and induces autophagy in ALS.

12 Apr 2018

Researchers explore treatment target for acute kidney injury

When you have diabetes then get an acute kidney injury there is a multiplier effect that can worsen your prognosis and destroy your kidneys.

10 Apr 2018

Resistance training enhances cellular recycling in muscle cells

A new study has shown that resistance training among previously untrained men increases autophagosome content, but that this effect may be blunted by aging.

9 Apr 2018

Cell-penetrating 'nanodrills' could be new platform for intracellular drug delivery

Researchers at Oregon State University and Oregon Health & Science University have created new nanomaterials able to cross cell membranes, establishing a novel platform for the intracellular delivery of molecular drugs and other cargo.

27 Mar 2018

Precision oncology may improve overall survival, lower healthcare costs for advanced cancer patients

The use of advanced molecular diagnostic technologies, such as Next-Generation Sequencing-based gene panel testing, to select targeted therapies in advanced cancer patients is known as precision oncology.

13 Mar 2018

Strict eating schedule can help clear away protein responsible for Huntington disease in mice

New research from the University of British Columbia suggests that following a strict eating schedule can help clear away the protein responsible for Huntington disease in mice.

6 Mar 2018

Study sheds light on biological mechanisms that drive rare pediatric neurogenetic disorders

Researchers studying a rare genetic disorder that causes severe, progressive neurological problems in childhood have discovered insights into biological mechanisms that drive the disease, along with early clues that an amino acid supplement might offer a targeted therapy.

22 Feb 2018

Study describes new protection mechanisms to fight neurodegeneration in Parkinson's and Alzheimer's

A new research study reveals RAC1 protein could be a new therapeutic target to study the molecular mechanisms related to the neurodegenerative processes in Parkinson's disease.

20 Feb 2018

Key proteins could help in controlling the risk of osteoarthritis during aging, Study finds

New study reveals that FOXO proteins help maintain healthy cells in the cartilage of the joints.

15 Feb 2018

TSRI study reveals potential strategy to prevent, treat osteoarthritis during aging

More than 30 million Americans suffer from osteoarthritis making it one of the most common age-related diseases.

15 Feb 2018

Impairing rare group of intestinal cells allows gut bacteria to cause inflammation, study finds

The human microbiome - the trillions of tiny bacteria that live in and on our bodies - is emerging as an increasingly important player in health and wellness. But, our co-existence with these organisms is complex, and scientists are learning that even minor changes in this relationship can lead to big problems with our health.

9 Feb 2018

Researchers uncover key protein that rescues progression of adult spinocerebellar ataxia

Spinocerebellar ataxia is a group of neurodegenerative diseases characterized by progressive incoordination of gait, and is often associated with poor coordination of hands, speech, and eye movements.

27 Jan 2018

Synergy between two neurotrophic factors exerts beneficial effect in early phase of Parkinson’s disease

Parkinson's disease is currently the second most widespread neurogenerative pathology. Current therapies are mainly of a replacement type and pose problems in the long term, so the challenge is to establish an early diagnosis and develop neuroprotective and neurorestorative therapies that will allow the symptoms of the disease to be slowed down or even reversed.

12 Jan 2018