Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Scientists discover molecular switch that determines death or survival of cell

The study is the result of a collaboration of scientists at Karolinska Institutet in Sweden, University of Michigan, and University of California San Diego, USA, who were interested in finding out whether autophagy can be affected by events in the cell nucleus. Surprisingly, they discovered that a signal chain in the nucleus serves as a kind of molecular switch that determines whether the cell dies or survives.

19 Jul 2013

TSRI scientists design drug candidate that increases exercise endurance in animal models

An international group of scientists has shown that a drug candidate designed by scientists from the Florida campus of The Scripps Research Institute (TSRI) significantly increases exercise endurance in animal models.

15 Jul 2013

HDAC10 gene plays a key role in autophagy and resistance to chemotherapy in high-risk neuroblastomas

Neuroblastomas are pediatric tumors that originate from cells of the embryonic nervous system. The disease can take widely varying clinical courses that range from spontaneous regression to fatal outcomes.

2 Jul 2013

Study shows autophagy blockers play a role in treatment of non-small-cell lung cancer

New research from Rutgers Cancer Institute of New Jersey, Princeton University and other collaborators suggests that inactivation of an essential gene responsible for the cell survival process known as autophagy can suppress the growth of non-small-cell lung cancer tumors and render them more benign.

1 Jul 2013

Decorin protein in blood inhibits tumor progression, say researchers

Researchers from Thomas Jefferson University's Kimmel Cancer Center have discovered that decorin, a naturally occurring protein that circulates in the blood, acts as a potent inhibitor of tumor growth modulating the tumor microenvironment.

28 Jun 2013

MCL-1 protein is vital for normal heart function, shows study

A study by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences and the Department of Pharmacology at the University of California, San Diego, shows that a protein called MCL-1, which promotes cell survival, is essential for normal heart function.

18 Jun 2013

Diachisis can occur during subacute phase of ischemic stroke, find USF researchers

While the effects of acute stroke have been widely studied, brain damage during the subacute phase of stroke has been a neglected area of research. Now, a new study by the University of South Florida reports that within a week of a stroke caused by a blood clot in one side of the brain, the opposite side of the brain shows signs of microvascular injury.

21 May 2013

AGA researchers to present exciting data on GI disorders at DDW 2013

Clinicians, researchers and scientists from around the world will gather for Digestive Disease Week- 2013, the largest and most prestigious gastroenterology meeting, from May 18 to 21, 2013, at the Orange County Convention Center in Orlando, FL.

18 May 2013

Mouse study shows leukemia halts accumulation of toxic proteins linked to Parkinson's disease

Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan a clinical trial in humans to study the effects.

10 May 2013

Special issue of Gastroenterology presents variety of topics related to pancreas

The editors of Gastroenterology, the official journal of the American Gastroenterological Association Institute, are pleased to announce the publication of this year's highly anticipated special 13th issue.

9 May 2013

BioLineRx starts enrollment in Phase I/II trial of BL-8020 for treatment of HCV

BioLineRx, a biopharmaceutical development company, announced today enrollment of the first patient in a Phase I/II trial for BL-8020, an orally available, interferon-free treatment for the Hepatitis C virus.

29 Apr 2013

Protein C4BP is possibly suitable as transporter for drugs, say researchers

The protein C4BP is similar to a spider in its spatial form with eight "arms". The structure of the "spider body" has recently been described in detail by researchers from the Helmholtz Centre for Infection Research in Braunschweig and the Technische Universit-t Darmstadt.

29 Apr 2013

Study highlights the protective effect of berries on brain function

Adding more color to your diet in the form of berries is encouraged by many nutrition experts. The protective effect of berries against inflammation has been documented in many studies.

22 Apr 2013

New research reveals how autophagy keeps neural stem cells to replace damaged brain, nerve cells

Deep inside your brain, a legion of stem cells lies ready to turn into new brain and nerve cells whenever and wherever you need them most. While they wait, they keep themselves in a state of perpetual readiness - poised to become any type of nerve cell you might need as your cells age or get damaged.

11 Apr 2013

TSRI scientists shed light on major toxic mechanisms of Alzheimer's disease

Scientists at The Scripps Research Institute have shed light on one of the major toxic mechanisms of Alzheimer's disease. The discoveries could lead to a much better understanding of the Alzheimer's process and how to prevent it.

11 Apr 2013

Researchers develop predictive biomarker to identify cancer patients who may respond to autophagy inhibitors

Autophagy, the process by which cells that are starved for food resort to chewing up their own damaged proteins and membranes and recycling them into fuel, has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation.

9 Apr 2013

Autophagy News and Research

Further Reading

Scientists discover molecular switch that determines death or survival of cell

TSRI scientists design drug candidate that increases exercise endurance in animal models

HDAC10 gene plays a key role in autophagy and resistance to chemotherapy in high-risk neuroblastomas

Study shows autophagy blockers play a role in treatment of non-small-cell lung cancer

Decorin protein in blood inhibits tumor progression, say researchers

MCL-1 protein is vital for normal heart function, shows study

Diachisis can occur during subacute phase of ischemic stroke, find USF researchers

AGA researchers to present exciting data on GI disorders at DDW 2013

Mouse study shows leukemia halts accumulation of toxic proteins linked to Parkinson's disease

Special issue of Gastroenterology presents variety of topics related to pancreas

BioLineRx starts enrollment in Phase I/II trial of BL-8020 for treatment of HCV

Protein C4BP is possibly suitable as transporter for drugs, say researchers

Study highlights the protective effect of berries on brain function

New research reveals how autophagy keeps neural stem cells to replace damaged brain, nerve cells

TSRI scientists shed light on major toxic mechanisms of Alzheimer's disease

Researchers develop predictive biomarker to identify cancer patients who may respond to autophagy inhibitors

TSRI scientists identify new drugs for human prion disease

Study: Protein clumps in nerve cells are pathologies of Parkinson's disease

Columbia University Medical Center, NewYork-Presbyterian Hospital present research works at AAN meeting

SDF-1 turns on autophagy that helps cells stay in place and focused on making bone

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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