BRCA1 Gene News and Research

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BRCA1 is a gene on chromosome 17 that normally helps to suppress cell growth. A person who inherits certain mutations (changes) in a BRCA1 gene has a higher risk of getting breast, ovarian, prostate, and other types of cancer.

Black women in the US less likely to access preventative cancer treatments

A report from the University of Pennsylvania School of Medicine in Philadelphia says that black women in the US with a family history of breast or ovarian cancer, are far less likely to seek genetic counselling and possible testing than their white counterparts, and although the reasons for the disparity are not clear, it is suspected that mistrust of both the medical system and advice from primary physicians may be factors.

12 Apr 2005

Mutated BRCA1 genes cause ovarian cancer indirectly

Mutated BRCA1 genes cause ovarian cancer indirectly, by interfering with the biochemical signals one ovarian cell sends to another, according to a team of researchers led by scientists at the USC/Norris Comprehensive Cancer Center and the Keck School of Medicine of the University of Southern California.

28 Mar 2005

Oral contraceptives may protect against breast cancer

Women at high genetic risk of breast cancer could reduce their risk of developing the disease at an early age by taking oral contraceptives, a new study has found. The findings contradict previous studies, which suggested oral contraceptive use would increase the risk of developing breast cancer.

22 Mar 2005

Women with non–invasive breast cancer carry the same mutations in two inherited breast/ovarian cancer genes as women diagnosed with invasive breast cancer

The inherited breast/ovarian cancer genes are BRCA1 and BRCA2, which are associated with an increased risk of breast and/or ovarian cancer. The results are part of a five–year study of a common form of early stage breast cancer called ductal carcinoma in situ (DCIS).

7 Mar 2005

Non-invasive and invasive breast cancers share the same genetic mutations

Women diagnosed with early stage, non–invasive breast cancer who carry the same mutations in two inherited breast/ovarian cancer genes as women diagnosed with invasive breast cancer, may benefit from high risk treatment, Yale researchers report in the February 23 issue of Journal of the American Medical Association.

23 Feb 2005

Breast conserving therapy safe for hereditary breast cancer

Women with hereditary breast cancer treated with breast conserving therapy appear to have no increased risk for recurrence in the treated breast, according to results from a prospective study published in the January 1, 2005 issue of CANCER, a peer-reviewed journal of the American Cancer Society.

23 Nov 2004

Study clarifies BRCA1 and BRCA2 links with other cancers

The largest population study ever done into the risk of cancer in families that fulfil the criteria for BRCA1 and BRCA2 mutation testing has confirmed that breast and ovarian cancers are the major concerns for geneticists and doctors counselling families.

14 Nov 2004

New insight into the role of the breast cancer gene known as BRCA2

Researchers at the Medical Research Council (MRC) Cancer Cell Unit, Cambridge have gained an important new insight into the role of the breast cancer gene known as BRCA2.

29 Oct 2004

Sister study that examines causes of breast cancer opens

A new study that will look at 50,000 sisters of women diagnosed with breast cancer opened today for enrollment across the United States. The Sister Study, conducted by the National Institute of Environmental Health Sciences (NIEHS), will investigate environmental and genetic causes of breast cancer.

18 Oct 2004

Support groups help women with breast cancer gene mutations

A new study finds support groups can relieve the anxiety and depression associated with carrying BRCA1 or 2 gene mutations, the so-called "cancer genes."

11 Oct 2004

50,000 women whose sisters had breast cancer needed for nationwide study

Women who know the angry, helpless feeling of watching a sister face breast cancer have gained a new, active, and personal way to fight the disease with the nationwide launch of The Sister Study.

26 Sep 2004

New method targeting hypermethylation detects ovarian cancer in the blood

Fox Chase Cancer Center researchers have found a new way to detect ovarian cancer in the blood. Reported in the Sept. 15, 2004, issue of Cancer Research, the new method targets hypermethylation--one mechanism used by cancer cells to turn off genes that protect against tumor development.

16 Sep 2004

MRI most effective for detecting breast cancer for women with breast cancer gene mutations

MRI is more accurate for detecting breast cancer than mammography, ultrasound or clinical breast examination alone, in women who carry the BRCA1 or BRCA2 gene mutation, according to a study in the September 15 issue of JAMA.

10 Sep 2004

National clinical trial on early detection of ovarian cancer available at Massey

Virginia Gov. Mark Warner declared September “Gynecological Cancer Awareness Month” in a certificate of recognition to Virginia Commonwealth University’s Massey Cancer Center.

1 Sep 2004

Further evidence about how estrogen helps activate breast cancer

A UC Irvine researcher has found a novel tumor- suppressor function for a gene that, when mutated, often triggers breast cancer in women.

29 Jul 2004

An interactive computer program can help educate women about breast cancer risk and genetic testing

An interactive computer program can help educate women about breast cancer risk and genetic testing, and a decision board offering information on treatment options can help breast cancer patients choose between mastectomy and breast-conserving therapy, according to articles in the July 28 issue of JAMA, the Journal of the American Medical Association.

28 Jul 2004

Chemoradioimmunotherapy for advanced breast cancer

A successful, and novel, technique to kill metastatic breast cancer cells by circumventing their chemo- and radioresistant mechanisms was by presented by Dr John Giannios, Head of Radiotherapeutic Cancer Research at the IASO Hospital

8 Jul 2004

Combining targeted immunotherapy with chemotherapy and radiation therapy to successfully kill metastatic tumour cells

A successful, and novel, technique to kill metastatic breast cancer cells by circumventing their chemo and radioresistant mechanisms was by presented by Dr. John Giannios, Head of Radiotherapeutic Cancer Research at the IASO Hospital

7 Jul 2004

Inheriting the wrong version of a gene called CHEK2 doubles a woman's risk of developing breast cancer

Inheriting the wrong version of a gene called CHEK2 doubles a woman's risk of developing breast cancer, Cancer Research UK scientists confirm in a major new international study published in the June edition of the American Journal of Human Genetics.

17 May 2004

Scientists find genetic link between prostate cancer and hereditary form of breast and ovarian cancer

A new study shows that the risk for prostate cancer is significantly elevated in men who are part of families with a hereditary form of breast and ovarian cancer. Researchers at Memorial Sloan-Kettering Cancer Center have determined that men in families carrying BRCA genetic mutations have a three- to five-fold increased risk of prostate cancer.

1 May 2004