BRCA2 Gene News and Research

RSS

BRCA2 is a gene on chromosome 13 that normally helps to suppress cell growth. A person who inherits certain mutations (changes) in a BRCA2 gene has a higher risk of getting breast, ovarian, prostate, and other types of cancer.

Variation in gene caspase-8 may help protect against breast cancer

A large-scale analysis of data on breast cancer risk has concluded that a common variation in the gene caspase-8 (CASP8) is associated with a somewhat lower risk of the disease. Variants are small changes that occur in a gene sequence.

13 Feb 2007

PALB2 gene mutation elevates risk of breast cancer four-fold

Cancer is a complex and common disease caused by a combination of both genetic and environmental factors. An inherited predisposition seems to be involved in at least 5-10 per cent of all cases of breast cancer.

11 Feb 2007

Vitamin D may slow down breast cancer

The authors of a new study are suggesting that vitamin D may slow down the progression of breast cancer.

17 Oct 2006

Breast and ovarian cancers linked by heredity - women need to know their risks

During September, Gynecologic Cancer Awareness Month, the Gynecologic Cancer Foundation (GCF) urges women to learn more about familial breast-ovarian cancer syndrome.

12 Sep 2006

Validation of a tool for identifying women at high risk for hereditary breast cancer

A new screening tool for the general practitioner effectively identifies patients at risk for hereditary breast cancer, according to a new study.

11 Sep 2006

Findings shed new light on BRCA1 and BRCA2 breast-cancer gene mutations in older and African-American women

Clearest picture yet of the prevalence and predictors of mutations in the breast-cancer susceptibility genes BRCA1 and BRCA2 among women in the general population.

15 Aug 2006

Variation in the CHEK2 gene may triple a woman's risk of developing breast cancer

Study shows that women in the general population who carry a specific CHEK2 mutation are three times as likely as women without the mutation to develop breast cancer.

2 Aug 2006

Women with mutations in BRCA1 or BRCA2 genes can reduce cancer risk by having ovaries removed

Women with mutations in the BRCA1 or BRCA2 genes can significantly reduce their risk of certain types of cancer by having their ovaries removed, according to a study in the July 12 issue of Journal of the American Medical Association.

12 Jul 2006

Scientists unravel breast cancer risk gene mystery

The risk of developing breast cancer is doubled in women who inherit a damaged version of a gene called ATM, according to a study published by Cancer Research UK funded scientists and collaborators in Nature Genetics.

10 Jul 2006

X-rays increase breast cancer risk

According to new research X-rays may significantly increase the risk of breast cancer in women who are genetically susceptible to the disease.

27 Jun 2006

Two year wait for breast cancer test results drives women to consider radical surgery

Women in the UK being put under added stress because they are experiencing delays of two years or more for test results to see if they carry a gene associated with an increased likelihood of breast cancer.

20 Jun 2006

New genetic clue discovered about breast cancer

New research has discovered that women in Iceland with a particular gene that raises the risk of breast cancer were virtually certain to develop the disease if they also had a mutation in another gene.

20 Jun 2006

Prophylactic surgery reduces the incidence of ovarian and related cancers

A new multicenter study is the first to suggest that the prophylactic removal of the ovaries and fallopian tubes may provide a different benefit for women who carry a genetic mutation in the BRCA2 gene than for those who have a BRCA1 genetic mutation.

7 Jun 2006

Hormonal treatments reduce risk of cancer returning

Women diagnosed with breast cancer who carry a certain genetic mutation can have breast-sparing surgery but should consider hormonal treatments to reduce their risk of cancer returning.

6 Jun 2006

MRI cost-effective for some women at high-risk of breast cancer

A computer model simulation suggests that adding breast MRI screening may be cost-effective for women of certain ages who carry BRCA1 and BRCA2 gene mutations.

23 May 2006

Extension of embryo screening will help reduce serious illness

A fertility watchdog in Britain, the Human Fertilisation and Embryology Authority (HFEA), has given approval for the extension of embryo screening to cover a wider range of mutated genes, in the main those which raise the risk of cancer in later life.

11 May 2006

New approach to treating breast cancer uses existing chemo drug

British scientists say women who develop breast cancer because of two common genetic mutations could have their treatment transformed by a chemotherapy drug which already exists.

1 May 2006

Remaining 80% of breast cancer genes may soon be discovered

We are closer to finding the missing 80% of breast cancer genes than ever before thanks to the success of the COSMIC database (Catalogue Of Somatic Mutations In Cancer) the 5th European Breast Cancer Conference (EBCC-5) was told today.

23 Mar 2006

Adjuvant hormonal therapy reduces contralateral breast cancer risk

The risk for a new cancer in the unaffected breast substantially increases in women diagnosed with unilateral, hereditary (non-BRCA) breast cancer, according to a new study.

17 Feb 2006

Broccoli, cauliflower and cabbage help repair damaged DNA

Need another reason to eat your vegetables? New research shows that some of them contain chemicals that appear to enhance DNA repair in cells, which could lead to protection against cancer development, say Georgetown University Medical Center researchers.

14 Feb 2006