Biochemistry News and Research

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Article outlines role of transcriptional mutagenesis in tumor development

DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.

5 Mar 2011

Protein serum amyloid A could be a potential diagnostic biomarker for lung cancer

Scientists are reporting discovery of a protein in the blood of lung cancer patients that could be used in a test for the disease - difficult to diagnose in its earliest and most treatable stages - and to develop drugs that stop lung cancer from spreading. Their study appears in ACS's Journal of Proteome Research.

3 Mar 2011

Glycogen study findings shed light on possible route to treat Lafora disease

Indiana University scientists have solved a perplexing mystery regarding one of the body's main energy storage molecules, in the process shedding light on a possible route to treatment of a rare but deadly disease in teenagers.

2 Mar 2011

Mathematical model predicts lifespan of stem cells

When patients receive a bone marrow transplant, they are getting a new population of hematopoietic stem cells. Fresh stem cells are needed when a patient is low on red blood cells, as in anemia, or white blood cells, which can be caused by cancer or even cancer treatments such as irradiation or chemotherapy. The problem is that a bone marrow transplant might not succeed because the transplanted stem cells don't live long enough or because they proliferate too well, leading to leukemia.

2 Mar 2011

Dermatan sulfate holds potential as an additional biomarker for Sanfilippo disease

Sanfilippo disease is a rare disorder caused by the failure of enzymes to break down specific kinds of complex carbohydrates, resulting in their accumulation in cells and often severe physical and neurological problems - and sometimes early death.

1 Mar 2011

Cancer drug may help combat flu

Ever get a flu shot and still get the flu? If so, there's new hope for flu-free winters in the years to come thanks to a new discovery by researchers who found that a drug called DMXAA, originally developed as anti-tumor agent, enhances the ability of flu vaccines to ward off this deadly virus.

1 Mar 2011

Research uncovers new details about protein interactions in retina

Science fiction novelist and scholar Issac Asimov once said, "The most exciting phrase to hear in science, the one that heralds new discoveries, is not 'Eureka!' but 'That's funny.' " This recently rang true for an international team of researchers when they observed something they did not expect.

1 Mar 2011

Final data from 4SC vidofludimus ENTRANCE Phase IIa trial against IBD presented at ECCO IBD Conference

4SC AG, a drug discovery and development company focused on autoimmune and cancer indications, announces the final data from the ENTRANCE Phase IIa trial in inflammatory bowel disease with vidofludimus, an oral inhibitor of interleukin-17 release and DHODH, including the secondary endpoints comprising the analysis of CDAI and CAI disease scores, change of prednisolone intake and threshold doses, safety, pharmacokinetics and biomarkers.

28 Feb 2011

Bruker to acquire Michrom Bioresources

Bruker today announced that it has signed an agreement to acquire Michrom Bioresources, Inc., a 20 year old, privately owned company based in Auburn, California. Michrom provides liquid chromatography instrumentation, accessories, and consumables for applications in the life science, chemical and applied markets.

24 Feb 2011

Multiplexed capillary isoelectric focusing increases efficiency in protein measurements

The Springer journal Analytical and Bioanalytical Chemistry (ABC) has chosen Oluwatosin O. Dada (34) as the recipient of its Best Paper Award 2010. Dada is the lead author of a paper in ABC on capillary isoelectric focusing. The award, accompanied by 1,000 euros, was created by Springer to help exceptional young scientists establish their research careers. The ABC Best Paper Award has been given since 2005.

24 Feb 2011

Ibio acquires Orphan Drug Designation and Fabry disease therapeutic program from Kentucky

iBio, Inc. today announced it has acquired Orphan Drug Designation for plant-produced human alpha galactosidase A and related property rights from an affiliate of Kentucky Bioprocessing LLC and has initiated a program, based on its iBioLaunch platform, to develop an improved version of the enzyme for therapy of Fabry disease.

23 Feb 2011

Biochemist receives STAC grant to find treatment for C. albicans infection in premature infants

A $200,000 grant from the Rhode Island Science and Technology Advisory Council is helping a Bryant University biochemist find a treatment for a fungal infection that is often lethal to premature infants.

23 Feb 2011

New DNA microarray detects genetic changes differentiating cancer patients from healthy individuals

A group of researchers led by scientists from the Virginia Bioinformatics Institute at Virginia Tech have developed a new technology that detects distinct genetic changes differentiating cancer patients from healthy individuals and could serve as a future cancer predisposition test.

23 Feb 2011

Tropical seaweed's antifungal chemical cues may have promising antimalarial properties for humans

A group of chemical compounds used by a species of tropical seaweed to ward off fungus attacks may have promising antimalarial properties for humans. The compounds are part of a unique chemical signaling system that seaweeds use to battle enemies - and that may provide a wealth of potential new pharmaceutical compounds.

22 Feb 2011

New study: Rapamycin reverses cardiac muscle damage in LEOPARD syndrome mouse model

Congenital heart diseases affect approximately one in 100 patients, making them the most common type of birth defect and the number-one cause of pediatric deaths.

21 Feb 2011

International study shows reprogramming cells lead to genomic aberrations

It's a discordant note in the symphony of good news that usually accompanies stem cell research announcements. Stem cells hold enormous promise in regenerative medicine, thanks to their ability to regenerate diseased or damaged tissues.

21 Feb 2011

Slime of starfish may hold a clue for treating inflammatory diseases

Starfish have arms, spines and a mouth on the underside of its body. But what scientists are finding really interesting is the sticky goo which is secreted when the Starfish feels threatened. The slime contains properties which may prove invaluable in treating certain kinds of inflammatory illnesses.

20 Feb 2011

Biologist investigates CAPV-EAE population for hereditary breast and ovary cancer

Between 5 % and 10 % of breast cancer cases are hereditary, arising because the patient inherits from the father or mother a mutation in a gene that is susceptible to causing the illness. BRCA1 and BRCA2 have already been identified as two of the genes to be monitored. It is estimated that 30 % of hereditary breast cancer cases are due to mutations in one of these two genes.

19 Feb 2011

Molecular explanation to higher tendency for autism among males

George Washington University researcher, Dr. Valerie Hu, Professor of Biochemistry and Molecular Biology, and her team at the School of Medicine and Health Sciences, have found that male and female sex hormones regulate expression of an important gene in neuronal cell culture through a mechanism that could explain not only higher levels of testosterone observed in some individuals with autism, but also why males have a higher incidence of autism than females.

17 Feb 2011

Ban called for allegedly carcinogenic caramel component in sodas

A consumer advocacy group has urged the U.S. Food and Drug Administration (FDA) this Wednesday to ban some chemically enhanced caramel food colorings used in widely consumed cola drinks as they could cause cancer.

16 Feb 2011

Biochemistry News and Research

Article outlines role of transcriptional mutagenesis in tumor development

Protein serum amyloid A could be a potential diagnostic biomarker for lung cancer

Glycogen study findings shed light on possible route to treat Lafora disease

Mathematical model predicts lifespan of stem cells

Dermatan sulfate holds potential as an additional biomarker for Sanfilippo disease

Cancer drug may help combat flu

Research uncovers new details about protein interactions in retina

Final data from 4SC vidofludimus ENTRANCE Phase IIa trial against IBD presented at ECCO IBD Conference

Bruker to acquire Michrom Bioresources

Multiplexed capillary isoelectric focusing increases efficiency in protein measurements

Ibio acquires Orphan Drug Designation and Fabry disease therapeutic program from Kentucky

Biochemist receives STAC grant to find treatment for C. albicans infection in premature infants

New DNA microarray detects genetic changes differentiating cancer patients from healthy individuals

Tropical seaweed's antifungal chemical cues may have promising antimalarial properties for humans

New study: Rapamycin reverses cardiac muscle damage in LEOPARD syndrome mouse model

International study shows reprogramming cells lead to genomic aberrations

Slime of starfish may hold a clue for treating inflammatory diseases

Biologist investigates CAPV-EAE population for hereditary breast and ovary cancer

Molecular explanation to higher tendency for autism among males

Ban called for allegedly carcinogenic caramel component in sodas

Biochemistry eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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