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TMDU researchers develop novel method to identify protein-protein binding interfaces

Proteins are building blocks of our bodies, but they do not work solo. They form partners to facilitate in different biological processes that keep us going.

20 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

UMass Amherst researchers develop novel strategy to outsmart antibiotic-resistant ‘superbugs’

Antibiotic-resistant "superbugs" that can defeat efforts to kill them are an urgent public health crisis, and according to the Centers for Disease Control, more than 2.8 million antibiotic-resistant infections occur each year.

18 Dec 2023

Deep learning designs high-affinity protein binders for bioactive helical peptides

A new study Dec. 18 in Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring.

18 Dec 2023

Spatial and subtype-specific regulation of ribosomal RNA genes in Arabidopsis revealed

Arabidopsis thaliana is a species grown worldwide for genetic research and was the first plant to have its complete set of chromosomes (its genome) sequenced.

15 Dec 2023

Researchers reveal a connection between cellular metabolism and depression, suicidal ideation

Major depressive disorder affects 16.1 million adults in the United States and costs $210 billion annually. While the primary symptoms of depression are psychological, scientists and doctors have come to understand that depression is a complex disease with physical effects throughout the body.

15 Dec 2023

Hemoglobin-like protein plays an important role in the development of the heart, study finds

In a landmark study led by the University of Maryland School of Medicine, researchers discovered for the first time that a certain kind of protein similar to hemoglobin, called cytoglobin, plays an important role in the development of the heart.

15 Dec 2023

Protective bacterial communities consume the nutrients to starve out pathogens

The human gut is home to hundreds of different bacterial species collectively known as the gut microbiome.

15 Dec 2023

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

A multidisciplinary study published in Nature has elucidated the structure of the machinery responsible for writing much of our "dark genome" -; the 98 percent of our DNA that has largely unknown biological function.

14 Dec 2023

Researchers unveil new way to sensitize resistant tumors to treatment

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death.

14 Dec 2023

UVA atlas unveils cellular blueprint of atherosclerosis

University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes and coronary artery disease.

12 Dec 2023

UB research identifies key mechanism in infantile cystinosis

University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the lifespan of patients.

11 Dec 2023

New drug combo shows promise in targeting RAS-mutant multiple myeloma

The combination of a drug and a protein fragment prevents the growth of blood cancer cells, a new study in mice shows.

11 Dec 2023

Study unlock secrets of Zika virus's multipurpose enzyme and reveals therapeutic vulnerability

Viruses have limited genetic material-;and few proteins-;so all the pieces must work extra hard. Zika is a great example; the virus only produces 10 proteins.

8 Dec 2023

Vanderbilt's potential schizophrenia treatment enters phase 1 clinical trials

A potential schizophrenia treatment discovered through the Warren Center for Neuroscience Drug Discovery has been cleared by the U.S. Food and Drug Administration for use in phase 1 clinical trials-;the third WCNDD therapeutic to reach that benchmark.

7 Dec 2023

New insights into the interplay between prions and TDP-43 in neurodegenerative pathology

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death.

4 Dec 2023

Scientists uncover new mechanism by which leukemia cells exploit cellular recycling process

In a recent study, scientists led by Professor Stefan Müller from Goethe University's Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML.

4 Dec 2023

New drug combination may improve treatment for rare nerve sheath tumors

Combining a pair of experimental drugs may help treat malignant peripheral nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigators at the Johns Hopkins Kimmel Cancer Center and Johns Hopkins Drug Discovery.

1 Dec 2023

Scientists uncover cellular cause of heart defects in babies born to women with diabetes

When women with diabetes become pregnant, they face not only the typical challenges of pregnancy and impending parenthood, but also a scary statistic: they're five times more likely to have a baby with a congenital heart defect.

30 Nov 2023

Collaborative study focuses on understanding the strength of adhesion of COVID-19 variants

A recent groundbreaking study, published in Nature Nanotechnology, sheds new light on the coronavirus's behavior, particularly its ability to remain attached under various mechanical stresses and the implications for person-to-person transmission.

29 Nov 2023

Biochemistry News and Research

TMDU researchers develop novel method to identify protein-protein binding interfaces

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

UMass Amherst researchers develop novel strategy to outsmart antibiotic-resistant ‘superbugs’

Deep learning designs high-affinity protein binders for bioactive helical peptides

Spatial and subtype-specific regulation of ribosomal RNA genes in Arabidopsis revealed

Researchers reveal a connection between cellular metabolism and depression, suicidal ideation

Hemoglobin-like protein plays an important role in the development of the heart, study finds

Protective bacterial communities consume the nutrients to starve out pathogens

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

Researchers unveil new way to sensitize resistant tumors to treatment

UVA atlas unveils cellular blueprint of atherosclerosis

UB research identifies key mechanism in infantile cystinosis

New drug combo shows promise in targeting RAS-mutant multiple myeloma

Study unlock secrets of Zika virus's multipurpose enzyme and reveals therapeutic vulnerability

Vanderbilt's potential schizophrenia treatment enters phase 1 clinical trials

New insights into the interplay between prions and TDP-43 in neurodegenerative pathology

Scientists uncover new mechanism by which leukemia cells exploit cellular recycling process

New drug combination may improve treatment for rare nerve sheath tumors

Scientists uncover cellular cause of heart defects in babies born to women with diabetes

Collaborative study focuses on understanding the strength of adhesion of COVID-19 variants

Biochemistry eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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