Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Blood clotting protein could be used as 'biomarker' for mucopolysaccharide diseases

University of Manchester scientists have shown that a protein involved in blood clotting can be used to diagnose and subsequently monitor the treatment of a group of childhood genetic diseases.

3 Feb 2011

Study reveals how MMSET gene enables disease-causing mutations to occur

For several decades, researchers have been linking genetic mutations to diseases ranging from cancer to developmental abnormalities. What hasn't been clear, however, is how the body's genome sustains such destructive glitches in the first place.

3 Feb 2011

USPTO issues notice of allowance to Vermillion's breast cancer biomarkers

Vermillion, a molecular diagnostics company, today announced that the United States Patent and Trademark Office has issued a notice of allowance for a patent entitled "Biomarkers for breast cancer" to the Company.

2 Feb 2011

AVEO commences enrollment in tivozanib Phase 2 study in renal cell carcinoma

AVEO Pharmaceuticals, Inc. today announced that it has initiated patient enrollment in a multi-center Phase 2 exploratory biomarker study of tivozanib, its lead product candidate designed to optimally block the VEGF pathway by inhibiting all three VEGF receptors, in patients with renal cell carcinoma (RCC).

1 Feb 2011

Avantra Biosciences selects TGen Drug Development for new biomarker quantitation platform

Avantra Biosciences today announced the selection of TGen Drug Development as a key test site for Avantra's new biomarker quantitation platform.

1 Feb 2011

News briefs from February issue of journal Chest

New research shows that vitamin D deficiency is prevalent among patients with interstitial lung disease (ILD), with the largest prevalence seen in patients with concurrent connective tissue disease (CTD).

1 Feb 2011

Scientists create 'reporter mouse' to close gap between kidney injury and diagnosis

The current check for kidney disease is a simple blood test for serum creatinine, but it can take longer than two days for this metabolite to accumulate to levels that are significant enough to indicate kidney damage - and by then it may be too late to intervene.

1 Feb 2011

CIHR announces $8.6 million for new research on Alzheimer's disease

the Honourable Leona Aglukkaq, Minister of Health, and the Honourable Julian Fantino, Minister of State for Seniors, today announced $8.6 million for new research on Alzheimer's disease.

29 Jan 2011

Cetero Research completes 20,000th early-phase clinical study

Cetero Research, the leading early-stage contract research organization, today announced that it has reached another industry milestone with the completion of its 20,000th early-phase clinical study.

28 Jan 2011

H3 Biomedicine introduces cancer research and development operations in Cambridge

H3 Biomedicine today announced that it has launched research and development operations in Cambridge, Massachusetts. H3 Biomedicine will undertake a comprehensive approach to breakthrough oncology treatments based on two primary principles: 1) the genetics of patients' cancers can reveal drug targets tailored to their cancers and 2) the advances in modern chemistry enable the discovery of new classes of safe and effective drugs against these targets.

27 Jan 2011

Avantra begins shipment of new Q400 Biomarker Workstation and Angio Qx BioChip Immunoassay

Avantra® Biosciences, a leading innovator in protein diagnostics, announced today their first shipments of the new Q400 Biomarker Workstation and the innovative Angio Qx™ BioChip Immunoassay.

27 Jan 2011

NanoString Technologies launches nCounter Mouse miRNA Expression Assay Kit

NanoString Technologies, Inc., a privately held life sciences company marketing a complete solution for detecting and counting large sets of target molecules in biological samples, today announced the expansion of its microRNA (miRNA) product line with a multiplexed assay for profiling the mouse miRNA transcriptome.

From NanoString Technologies 25 Jan 2011

New study shows biomarker test can aid in early, precise diagnosis of melanoma

A new study shows that a test of biomarkers for DNA methylation is technically feasible and could aid in earlier, more precise diagnosis of melanoma.

24 Jan 2011

FibroGen announces FG-3019 interim results from phase 1/2 trial against pancreatic cancer

FibroGen, today announced interim results of a phase 1/2 trial of FG-3019, a therapeutic antibody against connective tissue growth factor, in combination with gemcitabine and erlotinib in individuals with unresectable pancreatic cancer.

23 Jan 2011

Immunomedics reports encouraging results from Y-90-labeled clivatuzumab tetraxetan study in pancreatic cancer

Immunomedics, Inc., a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases, today announced that repeated therapy cycles of its proprietary antibody, clivatuzumab tetraxetan, labeled with yttrium-90 plus low-dose gemcitabine, extended median overall survival.

21 Jan 2011

Anti-depressants are passing into waterways and affecting fish

Around one in four Montrealers take some kind of anti-depressant, and according to new research, the drugs are passing into the waterways and affecting fish. The findings are internationally significant as the city's sewage treatment system is similar to that in use in other major cities, and moreover, it is reputed to be the third largest treatment system in the world.

21 Jan 2011

SQI fourth quarter net loss increases to $2,621,000

SQI Diagnostics Inc., a medical systems automation company focused on evolving laboratory-based autoimmune biomarker testing, today announced its financial and operational results for the fourth quarter and year ended September 30, 2010.

21 Jan 2011

RBM, SMA Foundation collaborate to develop plasma protein biomarkers for spinal muscular atrophy

The Spinal Muscular Atrophy Foundation and Rules-Based Medicine, announced today that they have reached the first milestone in a program to develop a panel of plasma protein biomarkers for SMA using RBM's Multi-Analyte Profiling technology platform.

21 Jan 2011

Study demonstrates prognostic value of DiagnoCure's Previstage GCC Colorectal Cancer Staging Test

DiagnoCure Inc., a life sciences company commercializing high‐value cancer diagnostic tests and delivering lab services, today announced positive initial results of a multi-center clinical study of 241 stage II colon cancer patients, a population categorized as low risk by traditional methods yet with an average recurrence rate of 20%.

20 Jan 2011

Almac reports substantial progress in transitioning operations to new headquarters

Almac is making substantial progress in transitioning operations to its new headquarters in Souderton, PA, especially in the area of distribution. The new facility has been successfully shipping clinical trial materials since November, and has recently seen an increase in shipment volumes due to the added efficiencies the new building provides.

19 Jan 2011

Biomarker News and Research

Further Reading

Blood clotting protein could be used as 'biomarker' for mucopolysaccharide diseases

Study reveals how MMSET gene enables disease-causing mutations to occur

USPTO issues notice of allowance to Vermillion's breast cancer biomarkers

AVEO commences enrollment in tivozanib Phase 2 study in renal cell carcinoma

Avantra Biosciences selects TGen Drug Development for new biomarker quantitation platform

News briefs from February issue of journal Chest

Scientists create 'reporter mouse' to close gap between kidney injury and diagnosis

CIHR announces $8.6 million for new research on Alzheimer's disease

Cetero Research completes 20,000th early-phase clinical study

H3 Biomedicine introduces cancer research and development operations in Cambridge

Avantra begins shipment of new Q400 Biomarker Workstation and Angio Qx BioChip Immunoassay

NanoString Technologies launches nCounter Mouse miRNA Expression Assay Kit

New study shows biomarker test can aid in early, precise diagnosis of melanoma

FibroGen announces FG-3019 interim results from phase 1/2 trial against pancreatic cancer

Immunomedics reports encouraging results from Y-90-labeled clivatuzumab tetraxetan study in pancreatic cancer

Anti-depressants are passing into waterways and affecting fish

SQI fourth quarter net loss increases to $2,621,000

RBM, SMA Foundation collaborate to develop plasma protein biomarkers for spinal muscular atrophy

Study demonstrates prognostic value of DiagnoCure's Previstage GCC Colorectal Cancer Staging Test

Almac reports substantial progress in transitioning operations to new headquarters

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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