Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

New approach to fighting cancer, based on nanoscale particles

Researchers at Rice University in Texas have developed a new approach to fighting cancer, based on nanoscale particles that can both detect and destroy cancerous cells. The report appears in the April 13 issue of the American Chemical Society's journal Nano Letters.

13 Apr 2005

Faster, more accurate diagnostic test for Sjogren's syndrome

Researchers in Japan are developing a faster, more accurate diagnostic test for Sjögren’s (SHOW-grins) syndrome, an incurable autoimmune disorder characterized by chronically dry eyes and dry mouth.

11 Apr 2005

New blood test improves the ability to diagnose or exclude congestive heart failure

A new blood test that measures a particular marker of cardiac distress can markedly improve the ability to diagnose or exclude congestive heart failure in patients with shortness of breath who come to hospital emergency departments.

11 Apr 2005

Public-health efforts to increase the use of breast-cancer screening appear to have altered the types of breast cancer being diagnosed

Since 1980, the incidence of ductal carcinoma in situ, or DCIS, one of the most common kinds of early stage breast cancer, has increased more than sevenfold. This sharp increase in DCIS – which is a tumor that contains cancer-like cells but is not considered "true" cancer because the cells have not invaded normal breast tissue – has been accompanied by a flattening in the incidence of true invasive breast cancer.

11 Apr 2005

Genomics and proteomics to increase the efficiency of drug discovery and development

While the United Sates is still the world leader, Europe is having a good deal of success in the field of advanced genomics and proteomics research. Significant government funding together with the presence of large pharmaceutical companies has made Europe a major competitor in the efforts to deploy genomics and proteomics as vital tools in drug discovery and development.

5 Apr 2005

Brain region recovery possible in former methamphetamine users

Adaptive changes in chemical activity in certain regions of the brain of former methamphetamine users who have not used the drug for a year or more suggest some recovery of neuronal structure and function, according to an article in the April issue of Archives of General Psychiatry.

4 Apr 2005

Airway inflammation boosts infarction damage

Epidemiological studies show that the incidence of cardiovascular disease (CVD) complications are increased in long standing cases of asthma. Historically, the complications are often attributed to the chronic drug therapy used to treat asthma.

3 Apr 2005

SERPINE2 identified as novel candidate gene for COPD susceptibility

Using a combination of genetic linkage, microarray gene expression and genetic association studies, a group of Brigham and Women’s Hospital/ Harvard Medical School researchers have identified a serine protease inhibitor clade E, member 2, or SERPINE2, “as a novel candidate susceptibility gene for COPD,” according to Sorachai Srisuma

3 Apr 2005

Novel protein marker for early diagnosis of kidney failure

Researchers have found a novel protein marker that can give a rapid and early diagnosis of kidney failure in children undergoing heart surgery, reporting their results in this week’s issue of The Lancet.

3 Apr 2005

New prostate cancer test

Tessera, Inc., a Seattle-based biomedical company, has released its first product, ProstaMark EPCA (Early Prostate Cancer Antigen), as an Analyte Specific Reagent (ASR) for commercial use in pathology laboratories to assist pathologists in their efforts to determine if cancer is present in the prostate.

28 Mar 2005

New guidelines mean tailor-made drugs are on the way

Many experts believe a milestone has been reached with the issuing of guidelines for pharmaceutical companies to encourage them to gather and submit information about how genetic variations affect the way people respond to their drugs.

23 Mar 2005

Ultrafast laser detection of cancer cells also may improve understanding of stem cells

To investigate tumors, pathologists currently rely on labor-intensive microscopic examination, using century-old cell-staining methods that can take days to complete and may give false readings.

23 Mar 2005

Oral contraceptives may protect against breast cancer

Women at high genetic risk of breast cancer could reduce their risk of developing the disease at an early age by taking oral contraceptives, a new study has found. The findings contradict previous studies, which suggested oral contraceptive use would increase the risk of developing breast cancer.

22 Mar 2005

ParAllele BioScience announces key patent issuance

ParAllele BioScience has announced the issuance by the U.S. Patent Office of a key patent (6,858,412) covering its Molecular Inversion Probe (MIP) technology. The patent is owned by Stanford University and is exclusively licensed to ParAllele.

21 Mar 2005

Heart disease risk in older women identified by simple blood test

Postmenopausal women who are not identified by traditional cardiovascular risk factors, could benefit from a simple blood test to show their white blood cell (WBC) count which may predict cardiovascular events and risk of death.

15 Mar 2005

Simple blood test may help to predict cardiovascular risk in older women

White blood cell (WBC) count may predict cardiovascular events and risk of death in postmenopausal women who are not currently identified by traditional cardiovascular risk factors, according to an article in the March 14 issue of Archives of Internal Medicine.

14 Mar 2005

ViroLogic and AstraZeneca to conduct Iressa biomarker study

ViroLogic announced today that it had entered into an agreement with AstraZeneca to conduct a cancer biomarker study with application to Iressa, AstraZeneca's selective epidermal growth factor receptor kinase inhibitor.

7 Mar 2005

Researchers can now predict who will benefit from cerclage

Doctors treating pregnant women with threatened preterm birth sometimes sew the cervix closed, a procedure known as cerclage. Despite this traditional intervention, many women still lose the pregnancy.

1 Mar 2005

Scientific experts discuss the benefits and safety of vitamin E

Scientific experts in pharmacology, toxicology and nutrition gathered at the University of Southern California (USC) on February 26 for a forum to discuss the benefits and safety of vitamin E.

1 Mar 2005

Measuring hyaluronan in joints and fluid that lubricates cartilage might enable doctors to diagnose osteoarthritis more accurately

Measuring a biological chemical called hyaluronan found naturally in joints and the fluid that lubricates cartilage might enable doctors to diagnose osteoarthritis of the knee and hip earlier or more accurately, a new study concludes.

27 Feb 2005

Biomarker News and Research

Further Reading

New approach to fighting cancer, based on nanoscale particles

Faster, more accurate diagnostic test for Sjogren's syndrome

New blood test improves the ability to diagnose or exclude congestive heart failure

Public-health efforts to increase the use of breast-cancer screening appear to have altered the types of breast cancer being diagnosed

Genomics and proteomics to increase the efficiency of drug discovery and development

Brain region recovery possible in former methamphetamine users

Airway inflammation boosts infarction damage

SERPINE2 identified as novel candidate gene for COPD susceptibility

Novel protein marker for early diagnosis of kidney failure

New prostate cancer test

New guidelines mean tailor-made drugs are on the way

Ultrafast laser detection of cancer cells also may improve understanding of stem cells

Oral contraceptives may protect against breast cancer

ParAllele BioScience announces key patent issuance

Heart disease risk in older women identified by simple blood test

Simple blood test may help to predict cardiovascular risk in older women

ViroLogic and AstraZeneca to conduct Iressa biomarker study

Researchers can now predict who will benefit from cerclage

Scientific experts discuss the benefits and safety of vitamin E

Measuring hyaluronan in joints and fluid that lubricates cartilage might enable doctors to diagnose osteoarthritis more accurately

Breath Biopsy®: The Complete Guide eBook

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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