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Phase 1/2 clinical study of bepotastine besilate nasal spray initiated for seasonal allergic rhinitis

ISTA Pharmaceuticals, Inc., today announced it has initiated a Phase 1/2 clinical study of bepotastine besilate nasal spray for the treatment of symptoms associated with seasonal allergic rhinitis, the inflammation of the nasal passages caused by allergies. The randomized, placebo-controlled, parallel-group study will evaluate the safety and efficacy of three concentrations of bepotastine besilate, dosed twice daily, in an Environmental Exposure Chamber model of allergic rhinitis caused by natural exposure to seasonal allergens.

14 Jul 2010

Cord Blood America to close BioCells acquisition by August end

Cord Blood America, Inc., the umbilical cord blood stem cell preservation company focused on bringing the life-saving potential of stem cells, a biological insurance policy, to families nationwide and internationally, today announced that all preliminary due diligence is now complete for the acquisition of controlling interest in BioCells, Inc. BioCells is headquartered in Argentina, with affiliates under development in Peru, Colombia, Bolivia, Panama and Puerto Rico. The acquisition is expected to be closed no later than August 31, 2010.

14 Jul 2010

Presidio Pharmaceuticals completes Phase 1a clinical trial of PPI-461 in healthy subjects

Presidio Pharmaceuticals, Inc. announced today the successful completion of a Phase 1a clinical trial of PPI-461, its lead HCV NS5A inhibitor, in healthy subjects. This first-in-human trial evaluated four single doses of PPI-461, followed by a five-day, once-a-day treatment regimen with PPI-461 at the highest tested dose.

14 Jul 2010

Scientists discover three human antibodies that neutralize HIV

Scientists have discovered three previously unknown human antibodies that neutralize HIV, two of which target a broad range of HIV strains. The findings, reported online July 8 in two Science papers, add a level of encouragement to the AIDS vaccine research field.

14 Jul 2010

New biological scaffolds will provide off-the-shelf tissue transplants

Professor John Fisher from The University of Leeds is speaking today (14 July) at the UK National Stem Cell Network Annual Science Meeting in Nottingham about his team's research into how biological scaffolding will pave the way for off- the-shelf tissue transplants.

14 Jul 2010

Exposure to cigarette smoke can alter gene expression, study finds

In the largest study of its kind, researchers at the Southwest Foundation for Biomedical Research have found that exposure to cigarette smoke can alter gene expression -- the process by which a gene's information is converted into the structures and functions of a cell. These alterations in response to smoking appear to have a wide-ranging negative influence on the immune system, and a strong involvement in processes related to cancer, cell death and metabolism.

14 Jul 2010

Loyola primary care physicians honored with Blue Ribbon rating from Blue Cross and Blue Shield

Loyola University Health System primary care physicians recently received a Blue Ribbon rating from Blue Cross and Blue Shield. This honor is given to physicians who have received a satisfaction rate of 85 percent or higher based on a member survey.

14 Jul 2010

Individual genes and networks that play an important role in inflammation, atherosclerosis identified

HemoShear, LLC, a leading developer of innovative, cell-based, human surrogate models for discovery and assessment of new drug compounds, has produced a profile of all of the genes that influence the biology and function of the human artery system. This research has generated valuable information on the entire spectrum of genes that are found in specific cell-types that make up human arteries.

14 Jul 2010

Researchers awarded $3M grant to establish DC D-CFAR

Researchers from institutions across Washington, DC, led by Alan E. Greenberg, M.D., M.P.H., of The George Washington University School of Public Health and Health Services, have been awarded an approximately $3M grant over five years from the National Institutes of Health to establish the District of Columbia Developmental Center for AIDS Research.

14 Jul 2010

Susceptibility to Behcet's disease associated with genes involved in body's immune response

Researchers with the National Institutes of Health have found susceptibility to Behcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response.

14 Jul 2010

Gene therapy represents safe alternative to current cures for blood disorder β-thalassemia

Italian scientists pioneering a new gene transfer treatment for the blood disorder β-thalassemia have successfully completed preclinical trials, claiming they can correct the lack of beta-globin (β-globin) in patients' blood cells which causes the disease. The research, published in EMBO Molecular Medicine, reveals how gene therapy may represent a safe alternative to current cures that are limited to a minority of patients.

14 Jul 2010

U.N. report released ahead of International AIDS Conference: HIV prevalence drops among young Africans

The number of new HIV infections among young people in Africa is falling in most of the "25 countries hardest hit by the virus," according to a report released Tuesday by UNAIDS, the Associated Press reports (Cheng, 7/13).

14 Jul 2010

Stimulation of single whisker prevents stroke in rats

Talk about surviving by a whisker. The most common type of stroke can be completely prevented in rats by stimulating a single whisker, according to a new study by UC Irvine researchers.

14 Jul 2010

LSUHSC Professor awarded $2.1M grant to determine role of PCP

Dr. Jay Kolls, Professor and Chairman of Genetics at the LSU Health Sciences Center New Orleans School of Medicine, has been awarded a $2.1 million grant over five years by the National Heart, Lung, and Blood Institute of the National Institutes of Health to determine the role and identify which T-helper cells fight the opportunistic infection, Pneumocystis carinii pneumonia, which can be a complication of HIV/AIDS.

14 Jul 2010

Study: Disruption of genes that control circadian rhythms may lead to diabetes

Disruption of two genes that control circadian rhythms can lead to diabetes, a researcher at UT Southwestern Medical Center has found in an animal study. Mice with defective copies of the genes, called CLOCK and BMAL1, develop abnormalities in pancreatic cells that eventually render the cells unable to release sufficient amounts of insulin.

14 Jul 2010

New research shows Alzheimer's disease may increase risk of other potentially disabling health conditions

Having Alzheimer's disease may increase the risk of getting other potentially disabling health conditions, including seizures and anemia, according to new research presented today at the Alzheimer's Association International Conference on Alzheimer's Disease 2010 in Honolulu, HI.

14 Jul 2010

Predictors of an Asian diabetes epidemic: A study

Experts believe diabetes will be the leading disease in Asia mainly because of the rise in consumption of junk and high calorie foods in this region of the world.

13 Jul 2010

Biggest breasted woman seriously ill after breast augmentation surgery

Brazilian model Sheyla Hershey, 30 apparently with the largest breasts in the world is seriously ill with complications following her latest breast augmentation surgery. Ms Hershey who lives in Houston, Texas contracted a severe staphylococcal infection after her surgery in June.

13 Jul 2010

Role of enzyme GSTP1-1 in progression of cancer, other diseases associated with increased cell proliferation

Telik, Inc. today announced the publication of a review in the journal, Cell Death and Differentiation: Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death; http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd201080a.html. This review describes recent advances in the understanding of the important role that the enzyme GSTP1-1 plays in the progression of cancer and other diseases associated with increased cell proliferation.

13 Jul 2010

Custom-made bone replacements for facial reconstruction soon

Facial reconstruction patients may soon have the option of custom-made bone replacements optimized for both form and function, thanks to researchers at the University of Illinois and the Ohio State University Medical Center.

13 Jul 2010

Blood News and Research

Phase 1/2 clinical study of bepotastine besilate nasal spray initiated for seasonal allergic rhinitis

Cord Blood America to close BioCells acquisition by August end

Presidio Pharmaceuticals completes Phase 1a clinical trial of PPI-461 in healthy subjects

Scientists discover three human antibodies that neutralize HIV

New biological scaffolds will provide off-the-shelf tissue transplants

Exposure to cigarette smoke can alter gene expression, study finds

Loyola primary care physicians honored with Blue Ribbon rating from Blue Cross and Blue Shield

Individual genes and networks that play an important role in inflammation, atherosclerosis identified

Researchers awarded $3M grant to establish DC D-CFAR

Susceptibility to Behcet's disease associated with genes involved in body's immune response

Gene therapy represents safe alternative to current cures for blood disorder β-thalassemia

U.N. report released ahead of International AIDS Conference: HIV prevalence drops among young Africans

Stimulation of single whisker prevents stroke in rats

LSUHSC Professor awarded $2.1M grant to determine role of PCP

Study: Disruption of genes that control circadian rhythms may lead to diabetes

New research shows Alzheimer's disease may increase risk of other potentially disabling health conditions

Predictors of an Asian diabetes epidemic: A study

Biggest breasted woman seriously ill after breast augmentation surgery

Role of enzyme GSTP1-1 in progression of cancer, other diseases associated with increased cell proliferation

Custom-made bone replacements for facial reconstruction soon

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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