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Study links glucose time series complexity to diabetes progression

Weiping Jia et al., at Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, China, conducted a study to explore the relationship between the complexity of glucose time series, as derived from continuous glucose monitoring (CGM), and the deterioration of glucose regulation.

9 Apr 2024

Research identifies how leukemia develops resistance to first line treatments

Relapses in a common form of leukemia may be preventable following new research which has identified how the cancer develops resistance to first line treatments.

9 Apr 2024

Childhood sedentariness associated with increase in blood insulin concentration, study shows

An increase in sedentary time from childhood is associated with a significant increase in blood insulin concentration, a new study shows.

9 Apr 2024

The complex relationship between obesity and male reproductive function

Authors have analyzed current evidence on the impact of obesity on the male reproduction system.

9 Apr 2024

Step steady: Consistent walking improves brain function in older adults

Study highlights that stabilizing daily step variability, rather than increasing total step counts, improves cognitive flexibility in older adults following a 10-week physical activity intervention.

8 Apr 2024

Adherence to the EAT-Lancet diet reduces the risk of heart failure

Adherence to the EAT-Lancet diet, rich in plant-based foods, is associated with a reduced risk of heart failure, potentially mediated by specific plasma proteins, in a large population-based cohort study.

8 Apr 2024

TAVR demonstrates lower risk and improved outcomes compared to SAVR in low-risk patients

Transcatheter aortic valve replacement (TAVR) was found to bring no increased risks and was associated with substantial decreased rates of death or stroke at one year in low-risk patients, compared with surgical aortic valve replacement (SAVR), according to findings presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Chronic low-level inflammation may be a contributor to both depression and heart disease

Coronary artery disease and major depression may be genetically linked via inflammatory pathways to an increased risk for cardiomyopathy, a degenerative heart muscle disease, researchers at Vanderbilt University Medical Center and Massachusetts General Hospital have found.

8 Apr 2024

Nerve ablation's varied outcomes in high blood pressure treatment

A new system that uses dehydrated alcohol to deactivate certain nerves surrounding the kidneys' arteries in order to control high blood pressure met its primary endpoint—lowering blood pressure at three months as measured with a 24-hour ambulatory systolic blood pressure monitor—in a pivotal phase 3 trial presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Preventive PCI reduces cardiac event risks in patients with high-risk plaque

People with a buildup of fatty atherosclerotic plaque in the heart's arteries considered at risk of rupturing were far less likely to suffer a serious cardiac event if they underwent percutaneous coronary intervention (PCI), a procedure to open blocked arteries, compared with those who took medications alone but did not undergo PCI, according to research presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

IVUS guidance improves angioplasty success rates in patients with peripheral artery disease

One-year success rates from angioplasty procedures to open clogged arteries in the legs were significantly higher among patients whose procedures were guided by intravascular ultrasound (IVUS) alongside angiography compared with those whose procedures were guided by angiography alone, in a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Ninerafaxstat shows good tolerability and safety in nonobstructive HCM patients

The investigational drug ninerafaxstat showed a good tolerability and safety profile, along with evidence of improvements in symptoms and exercise capacity among people with nonobstructive hypertrophic cardiomyopathy (HCM), according to results of a 12-week phase 2 trial presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

DEPOSITION trial evaluates the use of topical tranexamic acid during heart surgery

Administering tranexamic acid (TxA), a drug used to reduce bleeding during heart surgery, topically rather than intravenously did not meet its primary endpoint of reducing seizures and was stopped early due to an increased risk of bleeding events, according to research presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Treating early-stage heart failure in diabetic patients: Insights from ARISE-HF trial

One of the first studies to attempt to treat early-stage heart failure in patients with Type 2 diabetes did not meet its primary endpoint, but a preplanned subgroup analysis found a statistically significant effect of treatment in patients who were not taking SGLT2 inhibitors or GLP-1 RAs, which are antidiabetic medications that also have benefits for the heart.

8 Apr 2024

Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

8 Apr 2024

ACE inhibitors show no benefit in reducing chemotherapy-induced heart damage

Patients who took an angiotensin-converting enzyme (ACE) inhibitor while undergoing cancer treatment with high-dose anthracycline chemotherapy did not show any difference in troponin T levels, a biomarker associated with heart damage, at one month after their last chemotherapy dose compared with those who did not take an ACE inhibitor, according to a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Poor oral health linked to negative long-term systemic health outcomes

Those who report having poor oral health are as likely to have negative long-term systemic health outcomes as those previously diagnosed with periodontal disease, or gum disease, according to a new Tufts University School of Dental Medicine study published in The Journal of the American Dental Association.

8 Apr 2024

New technology uses a smartphone to analyze heart movement, detect heart failure

The new technology, which was created at the University of Turku and developed by the company CardioSignal, uses a smartphone to analyze heart movement and detect heart failure.

8 Apr 2024

Remote monitoring for COVID-19 patients shows no benefit from pulse oximetry

Using a pulse oximeter to measure oxygen levels is no better than just regularly asking patients with COVID-19 if they are short of breath, according to new research at the Perelman School of Medicine of the University of Pennsylvania.

8 Apr 2024

SMART trial shows comparable outcomes of two common TAVR devices in small aortic annulus patients

People with a small aortic annulus, a part of the heart's anatomy where the left ventricle meets the aorta, who underwent transcatheter aortic valve replacement (TAVR) with a supra-annular self-expanding valve saw similar clinical outcomes and superior valve performance at one year compared with those who underwent TAVR with a balloon-expandable valve, according to research presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

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Blood News and Research

Study links glucose time series complexity to diabetes progression

Research identifies how leukemia develops resistance to first line treatments

Childhood sedentariness associated with increase in blood insulin concentration, study shows

The complex relationship between obesity and male reproductive function

Step steady: Consistent walking improves brain function in older adults

Adherence to the EAT-Lancet diet reduces the risk of heart failure

TAVR demonstrates lower risk and improved outcomes compared to SAVR in low-risk patients

Chronic low-level inflammation may be a contributor to both depression and heart disease

Nerve ablation's varied outcomes in high blood pressure treatment

Preventive PCI reduces cardiac event risks in patients with high-risk plaque

IVUS guidance improves angioplasty success rates in patients with peripheral artery disease

Ninerafaxstat shows good tolerability and safety in nonobstructive HCM patients

DEPOSITION trial evaluates the use of topical tranexamic acid during heart surgery

Treating early-stage heart failure in diabetic patients: Insights from ARISE-HF trial

Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

ACE inhibitors show no benefit in reducing chemotherapy-induced heart damage

Poor oral health linked to negative long-term systemic health outcomes

New technology uses a smartphone to analyze heart movement, detect heart failure

Remote monitoring for COVID-19 patients shows no benefit from pulse oximetry

SMART trial shows comparable outcomes of two common TAVR devices in small aortic annulus patients

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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