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Single-cell study reveals clues to epigenetic drug response in Myelodysplastic Syndrome

Researchers from the Josep Carreras Leukaemia Research Institute, spearheaded by the Cancer Epigenetics group led by Dr. Manel Esteller, described the effects of chemotherapy at the single cell resolution in the bone marrow of Myelodysplastic Syndrome patients.

6 Feb 2024

Exploring how diets rich in saturated fats and cholesterol influence periodontal diseases

In a research, led by the University of Granada, in which researchers from the Universidad Europea del Atlántico (European University of the Atlantic, UNEATLANTICO), such as Mario Cordero and Maurizio Battino, it has been studied how diets rich in saturated fats and cholesterol influence certain aspects of periodontal diseases.

5 Feb 2024

Small-molecule A485 mobilizes white blood cells on demand

New study reveals a small molecule that can selectively mobilize white blood cells, offering potential treatments for diseases with abnormal leukocyte counts.

3 Feb 2024

Researchers discover mechanism that protects tissue after faulty gene expression

The genetic material, in the form of DNA, contains the information that is crucial for the correct functioning of every human and animal cell.

2 Feb 2024

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in "Science Immunology."

2 Feb 2024

$Large trial finds iodine-based antiseptic to be more effective for closed fracture surgery$

Large trial finds iodine-based antiseptic to be more effective for closed fracture surgery

A large multicenter clinical trial co-led by University of Maryland School of Medicine researchers large multicenter clinical trial co-led by University of Maryland School of Medicine researchers found that an antiseptic containing iodine resulted in about one-quarter fewer post-surgical infections in patients with limb fractures compared to another frequently used skin antiseptic.

2 Feb 2024

Phase II clinical trial evaluates the safety and efficacy of a Muse cell-based product in patients with ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor functions, which eventually leads to death within 5 years of its onset.

1 Feb 2024

Next-gen BTK degrader could help overcome treatment resistance in chronic lymphocytic leukemia

New research from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations has identified a next-generation BTK degrader that could help overcome treatment resistance in chronic lymphocytic leukemia (CLL) and related blood cancers.

1 Feb 2024

CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.

1 Feb 2024

Is there an association between vitamin D, immunocompetence, and aging?

The role of an individual’s immunocompetence in the responsiveness to vitamin D.

1 Feb 2024

Surge in syphilis cases leads some providers to ration penicillin

When Stephen Miller left his primary care practice to work in public health a little under two years ago, he said, he was shocked by how many cases of syphilis the clinic was treating.

1 Feb 2024

Scientists regenerate fully functional urinary bladder tissue using a non-human primate model

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University succeeded in regenerating fully functional urinary bladder tissue in a long-term study utilizing a non-human primate model.

30 Jan 2024

Vegan and keto diets trigger distinct immune system changes in just two weeks

Researchers at the National Institutes of Health observed rapid and distinct immune system changes in a small study of people who switched to a vegan or a ketogenic (also called keto) diet.

30 Jan 2024

Overcoming stigma to start early conversations about cognitive decline

Approximately four of five primary care clinicians consider themselves on the front lines of brain health.

30 Jan 2024

RNA sequencing analysis feasible for diagnosis of molecular subtypes in pediatric B-ALL

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, representing more than 30% of all pediatric cases.

29 Jan 2024

European scientists target high-risk childhood cancer with liquid biopsy

Neuroblastoma mainly affects toddlers and young children - in the EU region there are 1500 new cases per year.

29 Jan 2024

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024

NewsMedical speaks with Chao Ma, Ph.D. a Research Assistant Professor at New York University Tandon School of Engineering, ahead of his presentation at SLAS 2024.

From Society for Laboratory Automation and Screening (SLAS) 29 Jan 2024

Gene activity plays key role in immune cell production, study shows

As people age or become ill, their immune systems can become exhausted and less capable of fighting off viruses such as the flu or COVID-19.

27 Jan 2024

Sclerostin may protect against heart disease in patients with type 2 diabetes

A study carried out by the MP20-Biomarkers of Metabolic and Bone Diseases research group at the Biohealth Research Institute in Granada (ibs.GRANADA), led by UGR Professor Manuel Muñoz Torres, has provided significant insights into the role of sclerostin in protecting against atherosclerosis in patients with type 2 diabetes.

26 Jan 2024

The association between handgrip strength and functional outcomes in long COVID-19

The association between dynapenia with long coronavirus disease 2019 (COVID-19).

26 Jan 2024

Bone News and Research

Single-cell study reveals clues to epigenetic drug response in Myelodysplastic Syndrome

Exploring how diets rich in saturated fats and cholesterol influence periodontal diseases

Small-molecule A485 mobilizes white blood cells on demand

Researchers discover mechanism that protects tissue after faulty gene expression

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Large trial finds iodine-based antiseptic to be more effective for closed fracture surgery

Phase II clinical trial evaluates the safety and efficacy of a Muse cell-based product in patients with ALS

Next-gen BTK degrader could help overcome treatment resistance in chronic lymphocytic leukemia

CRISPR revolutionized: New method edits genes directly in the body

Is there an association between vitamin D, immunocompetence, and aging?

Surge in syphilis cases leads some providers to ration penicillin

Scientists regenerate fully functional urinary bladder tissue using a non-human primate model

Vegan and keto diets trigger distinct immune system changes in just two weeks

Overcoming stigma to start early conversations about cognitive decline

RNA sequencing analysis feasible for diagnosis of molecular subtypes in pediatric B-ALL

European scientists target high-risk childhood cancer with liquid biopsy

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024

Gene activity plays key role in immune cell production, study shows

Sclerostin may protect against heart disease in patients with type 2 diabetes

The association between handgrip strength and functional outcomes in long COVID-19

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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