Bone News and Research

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Stranger than science fiction?...Human sperm created from bone marrow

A team of scientists have created primitive human sperm in the laboratory by using bone-marrow tissue from male volunteers.

16 Apr 2007

Low serum testosterone levels independently associated with fall risk in elderly men

Prolonged hypogonadism may result in erectile dysfunction, decreased libido, anemia, sarcopenia, memory loss, bone mineral loss, and the metabolic syndrome.

15 Apr 2007

GlaxoSmithKline initiates study of PROMACTA in chronic idiopathic thrombocytopenic purpura

GlaxoSmithKline has announced the initiation of a global, open-label, single group trial that will assess the efficacy, safety and tolerability of PROMACTA (eltrombopag olamine) in patients previously treated for chronic idiopathic thrombocytopenic purpura (ITP).

15 Apr 2007

Human bone marrow has been used to create early-stage sperm cells

For the experiment, Prof Nayernia and his team took bone marrow from male volunteers and isolated the mesenchymal stem cells. These cells have previously been found to grow into other body tissues such as muscle.

15 Apr 2007

Dysfunctional DNA repair pathways

Individuals who inherit two mutant copies of any one of about 12 genes that make the proteins of the Fanconi Anemia (FA) pathway develop FA, which is characterized by increased incidence of cancer and bone marrow failure, among other things.

15 Apr 2007

Scientists discover key player in embryonic muscle development

Muscle fibers are large cells that contain many nuclei. They begin, like all animal cells, as naive embryonic cells. These cells differentiate, producing intermediate cells called myoblasts that are now destined to become muscle.

12 Apr 2007

Four genes found to drive spread of breast cancer to the lungs

Studies of human tumor cells implanted in mice have shown that the abnormal activation of four genes drives the spread of breast cancer to the lungs.

12 Apr 2007

Oncolytics Biotech to proceed with phase II Sarcoma trial

Oncolytics Biotech has announced that subsequent to the regulatory review period for this submission, it is proceeding with a Phase II trial to evaluate the intravenous administration of REOLYSIN in patients with various sarcomas that have metastasized to the lung.

11 Apr 2007

Calcium intake could be used as a prognostic factor for osteoporosis

Measuring a man's daily calcium intake is an effective way of identifying prostate cancer patients with a higher than average risk of osteoporosis, according to the April issue of the urology journal BJU International.

11 Apr 2007

dGEMRIC index as a predictor of cartilage mechanical stiffness

Can non-destructive MRI provide a measurement of cartilage function? The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used as a predictive measure of stiffness.

11 Apr 2007

Rep. Dave Weldon comments on stem therapy and type I diabetes

In yet another advance in adult stem cell therapy, the Journal of the American Medical Association (JAMA) today released a study in which 14 of 15 Juvenile Diabetes patients demonstrated significant improvement as a result of an adult stem cell treatment.

11 Apr 2007

Research shows relationship between low calcium intake and higher levels of osteoporosis in men with prostate cancer

Daily calcium intake is an effective way of identifying prostate cancer patients with a higher than average risk of osteoporosis, according to the April issue of the urology journal BJU International.

11 Apr 2007

Stem cells re-set the immune systems of diabetes patients

Researchers in Brazil and the U.S. have conducted an experiment which shows that stem cells can "re-set" the immune systems of diabetes patients.

10 Apr 2007

Modified bone marrow cells help recovery in an animal model of multiple sclerosis

These findings will need to be repeated in further animal models before the implications for human disease are clear; however, they open up an avenue of further research.

10 Apr 2007

Herbal treatment Forskolin may help knock out for urinary tract infections once and for all

Researchers in the United States have found that a common herbal extract which can be bought over the counter at health food stores, has the ability to cut down on urinary tract infections and may also enhance the effect of the antibiotics used to treat such infections.

8 Apr 2007

Lower doses of dexamethasone for multiple myeloma recommended

The International Myeloma Foundation (IMF) - supporting research and providing education, advocacy and support for myeloma patients, families, researchers and physicians - today said physicians should consider lowering the dose of the steroid dexamethasone when treating patients with multiple myeloma.

5 Apr 2007

Bariatric surgery - possible treatment for type 2 diabetes mellitus

What role could bariatric surgery possibly play as a treatment for type 2 diabetes mellitus? This topic and several others will be discussed at the American Association of Clinical Endocrinologists (AACE) Sixteenth Annual Meeting & Clinical Congress, Thursday, April 12, 2007 at the Washington State Convention & Trade Center in Seattle.

5 Apr 2007

Are multivitamins necessary?

Are multivitamins necessary? The April issue of Mayo Clinic Women's HealthSource answers this and other common questions about multivitamins.

5 Apr 2007

New blood test to rapidly detect levels of radiation exposure

In the event of a nuclear or radiological catastrophe -- such as a nuclear accident or a "dirty bomb" -- thousands of people would be exposed to radiation, with no way of quickly determining how much of the deadly substance has seeped inside their bodies.

4 Apr 2007

Washington University study China's earliest modern human

Researchers at Washington University in St. Louis and the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) in Beijing have been studying a 40,000-year-old early modern human skeleton found in China and have determined that the "out of Africa" dispersal of modern humans may not have been as simple as once thought.

4 Apr 2007