Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Researchers clarifiy role of Notch protein in T-cell development

Researchers at the University of Pennsylvania School of Medicine have recently clarified the role of the Notch protein in T-cell development. T cells are required for many aspects of immunity, including fighting viral infections, providing cancer surveillance, and regulating multiple aspects of the immune response.

6 Jul 2005

Discovery of genes that impact the development and function of blood stem cells

Researchers at the University of Minnesota have identified for the first time a group of genes that impact the development and function of blood stem cells, a discovery that brings researchers a step closer to harnessing the power of stem cells for disease treatments.

6 Jul 2005

Functional analysis of human hematopoietic stem cell gene expression using zebrafish

What do you get when you mix RNA chips and zebrafish? A new two-stage method for studying human gene expression differs in human stem cells and progenitor cells, according to a new article in the open access journal PLoS Biology.

6 Jul 2005

Scientists discover identifying markers for primitive blood-forming stem cells - simplifies cell identification

Scientists at the University of Michigan Medical School have discovered the biological equivalent of a grocery store bar code on the surface of primitive, blood-forming stem cells in mice. Called hematopoietic stem cells, they give rise to all the different types of specialized cells found in blood.

30 Jun 2005

Researchers successfully treat laboratory model of a lysosomal storage disease called GM1

Physicians might one day be able to treat a disease that destroys brain cells in children using genetically modified cells to transport a "drug" to the site of the dying neural cells (cells that transmit impulses).

27 Jun 2005

Simple analysis of a bone marrow transplant patient's oral rinse indicates whether infection will develop

Simple analysis of a bone marrow transplant patient's oral rinse can give medical personnel a quick indication of the transplant's effectiveness and predict whether an infection will develop, says a University of Toronto researcher.

27 Jun 2005

Scientists successfully isolate stem cells from human skin

Scientists at Wake Forest University School of Medicine have successfully isolated stem cells from human skin, expanded them in the laboratory and coaxed them into becoming fat, muscle and bone cells.

27 Jun 2005

Researchers develop method that can help doctors choose the best combination of drugs for fighting cancer

The method is based on a mathematical model that determines when a cancer becomes drug-resistant during therapy. It does this by estimating the probability of finding drug-resistant mutant cells at different stages of cancer progression and examining the fate of individual mutant colonies during therapy.

21 Jun 2005

Thalidomide may be a potent anti-cancer treatment

When people hear "thalidomide," many think "birth defects," however, evidence has come to light that this once-banned drug can be used as a potent anti-cancer treatment.

20 Jun 2005

Many pitfalls of aging result from either older stem cells or stem cells responding to their older environment

Older people are more prone to infections and have a higher risk of developing leukemia, and now researchers at Stanford University School of Medicine have one hint as to why that may be.

20 Jun 2005

Stem cells grown in lab mirror normal developmental steps

Johns Hopkins scientists have developed a way to study the earliest steps of human blood development using human embryonic stem cells grown in a lab dish instead of the embryos themselves.

20 Jun 2005

Stem cells to solve blood shortage problems

The State Government of Victoria, Australia announced that Melbourne scientists at Monash University have developed a unique technology that can grow large numbers of blood cells from human embryonic stem cells.

19 Jun 2005

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung.

16 Jun 2005

Scientists create new brain cells - in a dish

Regenerative medicine scientists at the University of Florida's McKnight Brain Institute have created a system in rodent models that for the first time duplicates neurogenesis - the process of generating new brain cells - in a dish.

13 Jun 2005

Half of 580 women diagnosed with breast cancer in one study experienced lymphedema

The good news is that there are nearly two million breast cancer survivors in the United States , and survival rates continue to increase for patients with this disease. But the flip side is that survival can present its own set of little-known complications.

12 Jun 2005

Genetics may play a role in the effectiveness of chemotherapy drugs

Today, the most common childhood cancer is cured in about 80 percent of patients; only forty years ago, this number was closer to five percent. In efforts to further increase the survival rate, researchers from St. Jude Children's Research Hospital, the University of Tennessee, and the University of Chicago studied how an individual's genetics might play a role in the effectiveness of chemotherapy drugs.

3 Jun 2005

Novel strategy proves highly effective in killing drug-resistant multiple myeloma cells

A novel strategy devised by Dana-Farber Cancer Institute scientists has proved highly effective in killing drug-resistant multiple myeloma cells in the laboratory and could open a new form of attack on the deadly blood cancer, they report.

2 Jun 2005

Long-term outcomes studied for stem cell transplant recipients

Improved techniques and supportive care have resulted in a growing number of long-term survivors of stem cell transplants, though little is known about the impact transplants have on patients’ lives long after treatment.

23 May 2005

Novel way of administering an anti-cancer drug to bone-marrow transplant patients using continuous infusion

The new method achieves more predictable, stable drug levels in patients than the current method and could eventually allow doctors to more accurately adjust doses to accommodate individual differences in metabolism, thus increasing treatment effectiveness while avoiding side effects, said University of North Carolina at Chapel Hill researchers.

20 May 2005

Infants with Krabbe disease saved by cord blood stem cells

Children with a fatal genetic disorder called Krabbe Disease can be saved and their brain development preserved if they receive stem cells from umbilical cord blood before symptoms of the disease develop, according to a study published in the current issue of the New England Journal of Medicine.

20 May 2005

Bone Marrow News and Research

Further Reading

Researchers clarifiy role of Notch protein in T-cell development

Discovery of genes that impact the development and function of blood stem cells

Functional analysis of human hematopoietic stem cell gene expression using zebrafish

Scientists discover identifying markers for primitive blood-forming stem cells - simplifies cell identification

Researchers successfully treat laboratory model of a lysosomal storage disease called GM1

Simple analysis of a bone marrow transplant patient's oral rinse indicates whether infection will develop

Scientists successfully isolate stem cells from human skin

Researchers develop method that can help doctors choose the best combination of drugs for fighting cancer

Thalidomide may be a potent anti-cancer treatment

Many pitfalls of aging result from either older stem cells or stem cells responding to their older environment

Stem cells grown in lab mirror normal developmental steps

Stem cells to solve blood shortage problems

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Scientists create new brain cells - in a dish

Half of 580 women diagnosed with breast cancer in one study experienced lymphedema

Genetics may play a role in the effectiveness of chemotherapy drugs

Novel strategy proves highly effective in killing drug-resistant multiple myeloma cells

Long-term outcomes studied for stem cell transplant recipients

Novel way of administering an anti-cancer drug to bone-marrow transplant patients using continuous infusion

Infants with Krabbe disease saved by cord blood stem cells

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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