Bone Marrow Transplant News and Research

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Editing away cancer and HIV in China: win or lose?

Scientists in China recently edited out the CCR5 gene from a patient with HIV's stem cells, but the research has sparked ethical debate.

13 Sep 2019

Bone marrow cells contribute to pregnancy success in mouse model

Scientists report that stem cells derived from the adult bone marrow can dictate whether a woman becomes pregnant.

13 Sep 2019

Scientists attempt to cure HIV using CRISPR, with varying results

Scientists have used the gene-editing technology CRISPR in an attempt to cure a person infected with HIV, with some success.

12 Sep 2019

Gene coding error likely responsible for rare form of inherited 'short telomere' disease

By combing through the entire genetic sequences of a person with a lung scarring disease and 13 of the person’s relatives, Johns Hopkins Medicine researchers say they have found a coding error in a single gene that is likely responsible for a rare form of the disease and the abnormally short protective DNA caps on chromosomes long associated with it.

From Johns Hopkins Medicine 11 Sep 2019

New therapy found to be effective for patients with a particular type of bone marrow cancer

Mount Sinai researchers have found a new type of therapy to be effective for patients with a particular type of bone marrow cancer that is resistant to several standard therapies, according to results of a clinical trial published in The New England Journal of Medicine in August.

22 Aug 2019

Despite failed promises, stem cell advocates again want taxpayers to pony up billions

Californians voted in 2004 to shell out billions of dollars in taxpayer money to fund cutting-edge stem cell treatments.

16 Aug 2019

First ever American gene-editing treatment using CRISPR for genetic disease

In a pathbreaking experiment, a 34-year-old mother of four from Mississippi is in the limelight for volunteering to be the subject of CRISPR-mediated gene editing in the hope of achieving a cure for the painful sickle cell anemia with which she has suffered all her life.

30 Jul 2019

Henry Ford Cancer Institute treats its first patient with CAR T-cell therapy

Henry Ford Cancer Institute has treated its first patient with CAR T-cell therapy, an approach that uses engineered cells from a patient's immune system to destroy cancer.

18 Jun 2019

More screening and new treatments needed for sickle cell disease

The promise of new treatments for sickle cell disease, a group of inherited red blood cell disorders, has never been so great, but it will only be realized if there is constant investment in health policies such as programs for screening newborns, especially in sub-Saharan Africa, where most cases occur.

13 Jun 2019

WVU researcher studies stubborn blood disease that strikes children

Treating a stubborn blood disease that strikes children may come down to tweaking energy production in stem cells, suggests research out of West Virginia University.

14 May 2019

Overlooked part of cell’s internal machinery may hold key to treating acute myeloid leukemia

Many individuals forced to fight an exceptionally aggressive form of the blood cancer acute myeloid leukemia (AML) don't survive more than five years.

22 Apr 2019

Study compares use of breast milk to formula in children who underwent bone marrow transplant

A new pilot study compared the use of human breast milk to formula in children less than 5 years of age who underwent bone marrow transplant (BMT), measuring the levels of inflammatory and pro-inflammatory biomarkers in the stool and blood to assess inflammatory injury to the intestinal microbiome.

5 Apr 2019

Surprising discovery offers clues to limit graft-vs.-host disease

A protein that protects people with inflammatory bowel disease has quite a different effect in graft-vs.-host disease, a common and challenging side effect of bone marrow transplants.

22 Mar 2019

Deadly inherited blood disorders cured with bone marrow transplant

Doubling the low amount of total body radiation delivered to patients undergoing bone marrow transplants with donor cells that are only "half-matched" increased the rate of engraftment from only about 50 percent to nearly 100 percent, according to a new study by Johns Hopkins researchers.

15 Mar 2019

Scientists move one step closer to a HIV cure

Scientists found no rebound of HIV in two patients who stopped taking their HIV medication after they received stem cell transplants for a hematological [blood] disease. Both patients underwent stem cell transplantation as part of their cancer treatment.

6 Mar 2019

British man with HIV becomes second person ever to enter remission

A man in Britain has become the second person in the world to be cleared of HIV after receiving a stem cell transplant from an HIV-resistant donor.

5 Mar 2019

11th IAS Conference on HIV Science to take place at Messe Berlin in 2021

Berlin is the host city of the 11th IAS Conference on HIV Science, the International AIDS Society announced today. The city hosted the 9th International AIDS Conference in 1993, but this is the first time that it will host the IAS Conference on HIV Science.

28 Feb 2019

New bioengineered device enhances the production of T-cells

Bone marrow transplants, also known as hematopoietic stem cell transplants, are life-saving treatments for aggressive diseases, such as leukemia and multiple myeloma, and infections such as HIV. The procedure entails infusion of blood stem cells from a matched donor into the patient to 'reset' the blood and immune system.

12 Feb 2019

New drug compounds show promise in treating acute myeloid leukemia

Researchers have been struggling for years to find a treatment for patients who have a recurrence of acute myeloid leukemia (AML), an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year, and about 10,670 people a year die from it, according to the American Cancer Society.

29 Jan 2019

Targeting Sirt-1 enzyme shows promise in controlling graft-vs-host disease

Bone marrow transplant offers patients with leukemia and lymphoma a potentially curative treatment. Bone marrow from the donor contains healthy immune cells, whose mission is to protect the body from invaders.

28 Jan 2019