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Stem cells from umbilical cord blood, given intravenously with mannitol drug reduce stroke size and damage

Researchers first gave the drug, mannitol, to provide temporary passage through the blood-brain barrier then transfused human umbilical cord blood cells into a stroke animal model. When used in the first hours and days following a stroke, stroke size decreased by 40 percent and resulting disability was significantly reduced.

26 Sep 2004

Histamine is key to narcolepsy

Narcolepsy is a disorder of sleep regulation that affects control of wakefulness and sleep and renders the patient subject to disabling sleepiness during the day.

23 Sep 2004

New gene therapy technique may help treat Alzheimer's disease

Investigators at Rush University Medical Center have successfully initiated a new technique that uses gene therapy to deliver nerve growth factor into regions of the brain where neurons are degenerating, in order to prevent cell death and reverse cell atrophy, two hallmarks of Alzheimer's disease.

21 Sep 2004

Discovery of dopamine terminal injury in brains of people with HIV dementia

Scientists at the U.S. Department of Energy’s Brookhaven National Laboratory have discovered a key mechanism in the brains of people with human immunodeficiency virus (HIV) dementia.

20 Sep 2004

Non-human primates should never be considered as source animals for any future clinical trials of animal-to-human transplantation

Australia’s leading health advisory body, the National Health and Medical Research Council, says there should be a five-year moratorium on any clinical research into animal-to-human whole organ transplants in Australia.

20 Sep 2004

New culprit behind the brain injury suffered by stroke victims

Researchers have uncovered a new culprit behind the brain injury suffered by stroke victims. Their new study, published in the Sept. 17 issue of Cell, links brain cell damage to a rise in brain acidity following the oxygen depletion, or ischemia, characteristic of stroke.

18 Sep 2004

Protein that causes juvenile Batten disease also plays a key role in normal cell function

The aberrant protein that causes juvenile Batten disease, a fatal neurodegenerative disorder of childhood, also plays a key role in normal cell function, Duke University Medical Center researchers have found.

16 Sep 2004

Researchers are making inroads to understanding what makes brain tumors so hard to treat

When he's not in the operating room performing surgery, Donald M. O'Rourke, M.D., Associate Professor of Neurosurgery at the University of Pennsylvania School of Medicine is fighting brain tumors from the research laboratory bench.

16 Sep 2004

Researchers get a grip on marijuana

Now researchers at Stanford University School of Medicine are a step closer to understanding how the drug's active ingredients - tetrahydrocannabinol and related compounds, called cannabinoids - may exert their effects.

16 Sep 2004

Disruption of protein folding causes neurodegeneration, mental retardation

Excess accumulation in brain cells of a fat molecule called GM1-ganglioside (GM1) disrupts the folding of newly assembled proteins into their proper shapes, triggering nerve degeneration and mental retardation in children.

10 Sep 2004

Pig tissue may help reduce the damage and disability of stroke

A tiny capsule containing tissue that secretes a cocktail of brain-nourishing neurotrophic factors may one day help reduce the damage and disability of stroke, according to research published in the September issue of Stroke.

7 Sep 2004

First Parkinson’s gene therapy patient well after 1 year suggesting that the therapy is safe and effective

The first ever patient to have undergone gene therapy for Parkinson’s appears to have come through phase I without a hitch, suggesting that the therapy is safe and effective, reports Marina Murphy in Chemistry & Industry.

2 Sep 2004

Hormone leptin could play a key role in treating bone loss, anorexia and infertility in women

A new study has found that the hormone leptin plays a key role in women’s reproductive and neuroendocrine health and suggests a future for the hormone in treating a number of conditions including exercise-induced bone loss, anorexia and in some cases of infertility.

2 Sep 2004

Alcohol in moderation maintains a healthy heart and reduces tissue damage following a heart attack

For years researchers have tried to determine why the French have such a lower rate of cardiovascular disease, given the amount of fat consumed in their diets.

30 Aug 2004

Further evidence of a genetic link to schizophrenia

Mice with specific genetic mutations exhibit behavior similar to human psychosis, report UT Southwestern Medical Center at Dallas researchers, providing further support to the notion of a genetic link to schizophrenia.

30 Aug 2004

Gray matter in brain associated with language processing among people with a family history of dyslexia

Italian researchers have observed significant reductions of gray matter volume in areas of the brain associated with language processing among people with a family history of dyslexia in comparison with controls with no reading problems.

24 Aug 2004

Stem cell research may one day help cerebral palsy

Natural chemicals that assist healing may one day help transplanted adult stem cells integrate into an injured brain, helping children with cerebral palsy recover lost function, according to researchers at the Medical College of Georgia.

18 Aug 2004

Newly discovered protein switch may be key to understanding sleep disorders, anxiety, and depression

University of California researchers have found that a newly discovered protein switch which they named neuropeptide S appears to work in the brain to enhance wakefulness and reduce anxiety in laboratory animals. According to Rainer Reinscheid and his colleagues, the protein could help in the understanding of sleep disorders, anxiety, and depression.

18 Aug 2004

The prion appears to function as an evolutionary stepping stone

“This prion,” explains Lindquist, “has a capacity to hide and release genetic information throughout the entire genome that can contribute to new traits in a complex way.”

16 Aug 2004

Study on RNAi technology targeting neurodegenerative diseases

Sirna Therapeutics has announced the publication of preclinical studies evaluating RNA interference-based therapies for a class of inherited neurodegenerative diseases of the central nervous system (CNS) in the current issue of Nature Medicine.

16 Aug 2004

Brain Cell News and Research

Stem cells from umbilical cord blood, given intravenously with mannitol drug reduce stroke size and damage

Histamine is key to narcolepsy

New gene therapy technique may help treat Alzheimer's disease

Discovery of dopamine terminal injury in brains of people with HIV dementia

Non-human primates should never be considered as source animals for any future clinical trials of animal-to-human transplantation

New culprit behind the brain injury suffered by stroke victims

Protein that causes juvenile Batten disease also plays a key role in normal cell function

Researchers are making inroads to understanding what makes brain tumors so hard to treat

Researchers get a grip on marijuana

Disruption of protein folding causes neurodegeneration, mental retardation

Pig tissue may help reduce the damage and disability of stroke

First Parkinson’s gene therapy patient well after 1 year suggesting that the therapy is safe and effective

Hormone leptin could play a key role in treating bone loss, anorexia and infertility in women

Alcohol in moderation maintains a healthy heart and reduces tissue damage following a heart attack

Further evidence of a genetic link to schizophrenia

Gray matter in brain associated with language processing among people with a family history of dyslexia

Stem cell research may one day help cerebral palsy

Newly discovered protein switch may be key to understanding sleep disorders, anxiety, and depression

The prion appears to function as an evolutionary stepping stone

Study on RNAi technology targeting neurodegenerative diseases

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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