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Key role of ion and water influx in T cell migration uncovered

Research reveals that T cell migration relies on ion and water influx for actin polymerization and movement, with the WNK1 kinase playing a critical role in regulating these processes, offering new insights into adaptive immunity.

10 Dec 2023

Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

A recent review in the journal Immunity delves into the crucial role of dendritic cells (DCs) in shaping T-cell responses in cancer, highlighting their importance in both priming anti-tumor immunity and in ongoing immune interactions within tumors. The findings underscore the potential of DCs as key targets for next-generation cancer immunotherapies.

18 Sep 2023

Self-directed autoantibodies against certain chemokines may protect against long-COVID

A recent study published in the journal Nature Immunology discovered autoantibodies against chemokines following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

8 Mar 2023

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy.

8 Jun 2021

Sex-differential COVID-19 responses are mediated by kynurenic acid

Now, a new study by a research team from Yale University, USA, Edith Cowan University, Australia, and the University of Strathclyde, Scotland, and published on the preprint server medRxiv in September 2020 shows that kynurenic acid is the underlying factor which is responsible for these differences.

9 Sep 2020

Newly designed hydrogels allow the culture of T-cells for use in cancer immunotherapy

A team with the participation of researchers from the Spanish National Research Council has designed new hydrogels that allow the culture of T-cells or T-lymphocytes, cells of the immune system that are used in cancer immunotherapy since they have the capacity to destroy tumor cells.

31 Aug 2020

Specific forms of lymphoma create their own survival niche

Cancer cells do not grow equally well everywhere in the body. Often, they first create the conditions in which they can grow. Many years ago researchers discovered that solid tumors attract blood vessels to ensure their supply of nutrients by secreting specific factors.

7 Jun 2011

New nano-vault delivery system can fight cancer

UCLA scientists have discovered a way to wake up the immune system to fight cancer by delivering an immune system-stimulating protein in a nanoscale container called a vault directly into lung cancer tumors, harnessing the body's natural defenses to fight disease growth.

4 May 2011