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New vaccine shows promise against toughest HIV strains

A new study reports successful immunization against a so-far invincible “death star” strain of an HIV-related laboratory virus (SIVmac239) and another tough strain. The new approach also achieves long-term protection with a single dose, showing that gene therapy could allow broad and durable protection, based on a modified form of the CD4 protein that allows HIV entry into human cells.

24 Jul 2019

Researchers identify encephalitis as rare toxicity of immunotherapy treatment

After a cancer patient receiving an immunotherapy developed encephalitis and died 18 months into treatment, researchers at Vanderbilt-Ingram Cancer Center investigated why the complication occurred, performing a molecular analysis of the disease's pathology and mining data to determine the incidence of similar occurrences.

22 Jul 2019

Study reveals how aggressive prostate cancer metastasizes by evading the immune system

Researchers at The University of Texas MD Anderson Cancer Center have discovered how an aggressive form of prostate cancer called double-negative prostate cancer (DNPC) metastasizes by evading the the immune system.

18 Jul 2019

HIV therapy leaves unrepaired holes in the immune system's wall of defense

If they don't receive antiretroviral therapy (ART), most HIV patients see a progressive weakening of their immune system.

16 Jul 2019

Patients with HIV DNA in cerebrospinal fluid have high risk of experiencing cognitive deficits

Investigators from the AIDS Clinical Trials Group, the world's largest and longest-established HIV research network, today announced that the Journal of Clinical Investigation published new findings from the ACTG HIV Reservoirs Cohort Study.

16 Jul 2019

WHO's 'Treat All' HIV recommendation widely adopted globally

Faced with a global epidemic of HIV, the World Health Organization advised back in 2015 that a new health policy, summed up as “Treat All”, be adopted in all health facilities around the world that deal with HIV patients.

16 Jul 2019

Reprogramming cells to control HIV infection

Cells from the rare individuals who naturally control HIV infection have been the focus of investigation for nearly 15 years with the aim of elucidating their specific features.

14 Jul 2019

Researchers discover new immune cells that are at the frontline of HIV infection

Researchers at The Westmead Institute for Medical Research have discovered brand new immune cells that are at the frontline of HIV infection. Known as CD11c+ dendritic cells, these new cells are more susceptible to HIV infection and can then transmit the virus to other cells.

24 Jun 2019

Most preferred drug for HIV may not be as safe as suggested

A study lead by researchers at the Institute of HIV Research, Medical Faculty of UDE and University Hospital Essen, stumbled over a potential toxicity of integrase inhibitors.

21 Jun 2019

Researchers find more effective way to treat drug-resistant cancers

Researchers at SMU's Center for Drug Discovery, Design and Delivery have succeeded in lab testing the use of chemotherapy with a specific protein inhibitor so that the chemotherapeutic is better absorbed by drug-resistant cancer cells without harming healthy cells.

10 Jun 2019

Increasing access to mental health services improves outcomes for people with HIV

Increasing access to mental health services improves HIV outcomes among vulnerable patients, a new study from the University of Virginia School of Medicine suggests.

21 May 2019

Finding potential treatments for autoimmune diseases

More than 50 million Americans are affected by an autoimmune disease, with women at an increased risk for developing one.

7 May 2019

Scientists identify rare, paradoxical response to antiretroviral therapy

Antiretroviral therapy is usually very effective at suppressing HIV in the body, allowing a person's immune system to recover by preventing the virus from destroying CD4+ T cells.

19 Apr 2019

Breakthrough antibody treatment suppresses HIV without antivirals

A new research paper describes how an antibody that prevents HIV binding to human immune cells was shown to be able to suppress levels of HIV for up to four months.

18 Apr 2019

Sexual behavior could affect gut microbiome and immune system

A person's sexual behavior could affect their microbiome and immune system, potentially elevating their risk of HIV infection, according to a new study from researchers at the University of Colorado Anschutz Medical Campus.

10 Apr 2019

Study finds no major epigenetic differences between space astronaut and his earthbound twin brother

In a landmark study, a group of U.S. scientists from Johns Hopkins, Stanford University and other institutions has found no long-lasting, major differences between the epigenomes of astronaut Scott Kelly, who spent a year in space aboard the International Space Station, and his twin brother, Mark, who remained on Earth.

9 Apr 2019

Gut microbiome may drive HIV transmission risk in high-risk men

Gut microbes from high HIV-risk men who have sex with men drive immune activation in mice and HIV infection in cells, according to a study published April 4 in the open-access journal PLOS Pathogens by Brent Palmer and Catherine Lozupone of the University of Colorado Anschutz, and colleagues.

8 Apr 2019