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Research unravels how cytokines prevent multi-organ damage during parasitic infection

Cytokines are proteins secreted by several types of immune cells in response to infection, inflammation, or injury. Interleukin-17 (IL-17) is one such cytokine that causes inflammation, by controlling the production of other cytokines and mobilizing a type of white blood cell (neutrophil) that fights infections.

3 Apr 2017

Researchers shed light on how immune cells weaken with age

Researchers from the European Bioinformatics Institute, University of Cambridge, the Wellcome Trust Sanger Institute and the Cancer Research UK–Cambridge Institute have shed light on a long-standing debate about why the immune system weakens with age.

3 Apr 2017

City of Hope researchers to highlight basic cancer research and population studies at AACR meeting

City of Hope, a world-renowned independent research and cancer and diabetes treatment center, will highlight a variety of basic research and population studies at the annual meeting of the American Association for Cancer Research at the Walter E. Washington Convention Center in Washington, D.C., April 1 to 5.

28 Mar 2017

One-shot vaccine passes key preclinical test in newborn monkey models

Newborns are highly vulnerable to infections and don't respond optimally to most vaccines because their young immune systems typically mount weak antibody responses.

24 Mar 2017

Penn researcher receives $16.3 million NIAID grant to develop long-sought-after HIV vaccine

Building on earlier work in designing chimeric human-simian immunodeficiency viruses (SHIVs) that serve as a model of HIV infection of humans, George M. Shaw, MD, PhD, a professor of Hematology/Oncology and Microbiology in the Perelman School of Medicine at the University of Pennsylvania, has received $16.3 million over five years from the National Institute of Allergy and Infectious Diseases to develop a long-sought-after HIV vaccine.

22 Mar 2017

CD4+ T-cell count may not be helpful to assess ART response in HTLV-1/HIV co-infected patients

The authors compared the CD4+ T-cell counts and HIV-1 RNA viral loads of 383 patients who were either mono-infected with HIV or co-infected with HTLV-1/HIV.

17 Mar 2017

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

New research findings published in the Journal of Leukocyte Biology, suggest that synovial CD4+ T cells that produce IL-21 contribute to joint inflammation by activating synovial fibroblasts in rheumatoid arthritis patients.

2 Mar 2017

Activated T-cells promote heart failure after heart attack

Chronic inflammation after a heart attack can promote heart failure and death. University of Alabama at Birmingham researchers have now shown that activated T-cells — part of the immune system's inflammatory response — are both necessary and sufficient to produce such heart failure.

28 Feb 2017

Only subset of mother's HIV virus infects infants during pregnancy or breastfeeding, research shows

In the transmission of HIV-1 from mother to child only a subset of a mother's viruses infects their infants either in utero or via breastfeeding, and the viruses that are transmitted depend on whether transmission occurs during pregnancy or through breastfeeding, according to UCLA-led research.

15 Feb 2017

New Zika vaccine candidate shows potential to protect against virus with single dose

A new Zika vaccine candidate has the potential to protect against the virus with a single dose, according to a research team led by scientists from the Perelman School of Medicine at the University of Pennsylvania.

2 Feb 2017

UAB researchers find how gut fails to prevent HIV-1 infection

The barrier between the gut and the bloodstream is severely damaged in the first few weeks of infection by HIV-1 virus.

28 Jan 2017

New genital herpes vaccine candidate shows promising results in preclinical tests

Approximately 500 million people around the world are infected with the genital herpes virus known as herpes simplex virus 2 (HSV2).

20 Jan 2017

Research findings could lead to development of novel therapeutic approaches against viral infections

Life is a question of balance, and the body is no exception. Expression levels of certain proteins can affect the immune system's ability to neutralize a virus.

12 Jan 2017

Researchers identify sub-population of HIV-1 strains with biological properties to transmit new infections

Upon sexual exposure, the AIDS virus must overcome some mighty barriers to find the right target cell and establish a new infection.

11 Jan 2017

Blocking protein that initiates immune response against viral infections may help combat HIV

In findings they call counterintuitive, a team of UCLA-led researchers suggests that blocking a protein, which is crucial to initiating the immune response against viral infections, may actually help combat HIV.

23 Dec 2016

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Investigators from Whitehead Institute, the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used CRISPR-Cas9 gene-editing technology to identify three promising new targets for treatment of HIV infection.

20 Dec 2016

Researchers create 2-for-1 vaccine that protects mice from MERS and rabies

In a new study, researchers have modified a rabies virus, so that it has a protein from the MERS virus; this altered virus works as a 2-for-1 vaccine that protects mice against both Middle East Respiratory Syndrome (MERS) and rabies.

7 Dec 2016

Project to help those living with HIV launched by Beckman Coulter

Beckman Coulter Life Sciences is launching an international HIV/AIDS award at the 2016 conference for the African Society for Laboratory Medicine (ASLM) being held in Cape Town, South Africa (December 3 to 8).

From Beckman Coulter Diagnostics 5 Dec 2016

Scientists develop genetically engineered T cells with fusion inhibitor to disrupt HIV's harpoon

When HIV attacks a T cell, it attaches itself to the cell's surface and launches a "harpoon" to create an opening to enter and infect the cells.

18 Nov 2016

NIH researchers identify antibody that potently neutralizes 98% of HIV strains

Scientists from the National Institutes of Health have identified an antibody from an HIV-infected person that potently neutralized 98 percent of HIV isolates tested, including 16 of 20 strains resistant to other antibodies of the same class.

15 Nov 2016