Cancer diagnostics News and Research

RSS

Oxford COVID vaccine technology has the potential to revolutionize cancer treatment

Scientists from the University of Oxford and the Ludwig Institute for Cancer Research are building on the success of the Oxford-AstraZeneca vaccine against SARS-CoV-2 to develop a vaccine to treat cancer.

21 Sep 2021

'Cold' tumors can be turned 'hot' with extremely low doses of radiation, study shows

A Ludwig Cancer Research study conducted in both mice and a small group of patients with advanced cancers has shown that so-called “cold” tumors that are nearly devoid of immune cells—and therefore unresponsive to immunotherapy—can be turned “hot” with extremely low doses of radiation and the rational use of existing therapies.

9 Sep 2021

Transient chromosomal errors can spur the formation of tumors, study finds

A Ludwig Cancer Research study has found that inducing random chromosome instability (CIN) events in mice for as little as one week is enough to trigger harmful chromosomal patterns in cells that spur the formation of tumors.

16 Jul 2021

MIT engineers create new diagnostic nanoparticle that can pinpoint tumor location

Most of the tests that doctors use to diagnose cancer -- such as mammography, colonoscopy, and CT scans -- are based on imaging. More recently, researchers have also developed molecular diagnostics that can detect specific cancer-associated molecules that circulate in bodily fluids like blood or urine.

16 Jul 2021

MRI screening and targeted biopsies could reduce overdiagnoses of prostate cancer

Most countries have not introduced nationwide prostate-cancer screening, as current methods result in overdiagnoses and excessive and unnecessary biopsies. A new study by researchers at Karolinska Institutet in Sweden, which is published in The New England Journal of Medicine, indicates that screening by magnetic resonance imaging (MRI) and targeted biopsies could potentially cut overdiagnoses by half.

9 Jul 2021

Mutations in HER2 gene can spur tumor growth in breast cancer

Mutations in a gene related to HER2, a gene frequently implicated in breast cancers and a variety of other malignancies, can amplify activity that spurs tumor growth, a new study led by UT Southwestern researchers suggests.

25 Jun 2021

Foresight Diagnostics to demonstrate utility of PhasED-Seq technology at ICML meeting

Foresight Diagnostics, the emerging leader in blood-based lymphoma disease monitoring, announced today that clinical performance of its minimal residual disease (MRD) detection platform in diffuse large B-cell lymphoma (DLBCL) will be presented at the 16th International Conference on Malignant Lymphoma (ICML) on June 18-22, 2021.

18 Jun 2021

Macrophages can aid tumor growth by distracting cancer-killing CD8+ T cells

A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid tumor growth by distracting the immune system's cancer-killing CD8+ T cells.

11 Jun 2021

Pancreatic cancer cells de-differentiate to spawn highly aggressive tumors, study shows

A Ludwig Cancer Research study has identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert-or "de-differentiate"-to a progenitor, or immature, state of cellular development to spawn highly aggressive tumors that are capable of metastasis to the liver and lymph nodes.

29 Apr 2021

Impact of proposed law would increase regulatory oversight of certain diagnostic tests

Legislation currently under consideration in the U.S. Congress would increase regulatory oversight of certain diagnostic tests, and a new study by researchers at Massachusetts General Hospital (MGH) and colleagues from several other institutions demonstrates that its potential impact will depend on key details in the bill's final language.

22 Apr 2021

Researchers confirm a threshold value for non-invasive imaging biomarker

Breast cancer is the commonest fatal cancer in women. Early detection increases a woman's chances of recovery. Magnetic Resonance Imaging (MRI) is an accurate technique for detecting and classifying tumors in breast tissue.

2 Mar 2021

Study suggests a new way to personalize anti-CTLA-4 therapy for cancers

A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors.

15 Feb 2021

Algorithm for skin cancer diagnosis performs on par with dermatologists

A study has now been presented that boosts the evidence for using AI solutions in skin cancer diagnostics.

13 Feb 2021

Better design of deep learning studies can lead to faster transformation of medical practices

A new Perspective article in Nature Reviews Cancer discusses reasons for the moderate progress and describes remedies designed to facilitate the transition to the clinic.

5 Feb 2021

Study shows how gut bacteria can dull the efficacy of radiotherapy

A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients.

26 Jan 2021

New study helps understand molecular profile of tumors in cancer patients

Researchers from the University Hospitals in Zurich and Basel, ETH Zurich, University of Zurich and the pharmaceutical company Roche have set out to improve cancer diagnostics by developing a platform of state-of-the-art molecular biology methods.

21 Jan 2021

Researchers immunoengineer nanobead system for circulating tumor cell detection

A team of researchers has immunoengineered a nanobead system for the isolation and detection of circulating tumor cells.

21 Jan 2021

Study offers a differentiated patient-specific solution in minimal residual disease testing

Exact Sciences Corp. today announced that it has acquired a worldwide exclusive license to the proprietary TARDIS technology from the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.

15 Jan 2021

Researchers investigate prognostic role of diversity of chromatin compartments in gynecological cancers

A novel marker might contribute to selecting high-risk stage I ovarian carcinoma patients for adjuvant chemotherapy and low-risk endometrial carcinoma patients for less extensive surgery.

8 Jan 2021

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to generate drug resistance in cancer.

24 Dec 2020