Carcinogenesis News and Research

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Suspect protein HMGB1 found to promote DNA repair, prevent cancer

An abundant chromosomal protein that binds to damaged DNA prevents cancer development by enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in the Proceedings of the National Academies of Science.

21 Jul 2008

Vitamin D protects cells from stress that can lead to cancer

By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report.

13 May 2008

Whole-organ genomic survey depicts journey from normal to malignant cell

Whole-organ maps that superimpose genetic information over the terrain of cancerous bladders chart the molecular journey from normal cell to invasive cancer, an international research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports online at the journal Laboratory Investigation.

5 May 2008

Small molecule nutlin-3a activates an important cancer suppressor gene

By activating a cancer suppressor gene, a small molecule called nutlin-3a can block cancer cell division, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health.

1 May 2008

Early treatment of Helicobacter pylori infection may prevent cancer

Based on research using a new mouse model of gastritis and stomach cancer, researchers from the Massachusetts Institute of Technology (MIT) say that prompt treatment of Helicobacter pylori (H. pylori) infections reverses damage to the lining of the stomach that can lead to cancer.

1 May 2008

Discovery of primary driver of tumor development in the stomach

In a discovery that could lead to the development of new treatments for gastric cancer, scientists at the Melbourne Branch of the international Ludwig Institute for Cancer Research (LICR) have discovered what appears to be the primary driver of tumor development in the stomach.

22 Apr 2008

Restricted calorie diets prevent pancreatic inflammation and cancer

Prevention of weight gain with a restricted calorie diet sharply reduced the development of pancreatic lesions that lead to cancer in preclinical research reported today by researchers from The University of Texas at Austin and The University of Texas M. D. Anderson Cancer Center at the American Association for Cancer Research annual meeting.

16 Apr 2008

Restricted-calorie diets limit development of epithelial cancers

A restricted-calorie diet inhibited the development of precancerous growths in a two-step model of skin cancer, reducing the activation of two signaling pathways known to contribute to cancer growth and development, researchers at The University of Texas M. D. Anderson Cancer Center report today at the American Association for Cancer Research annual meeting.

15 Apr 2008

What we eat and drink affects our risk of cancer

A healthy diet and lifestyle protect against a wide range of diseases, and new research presented at the American Association for Cancer Research 2008 Annual Meeting, April 12-16, shows that cancer is no exception.

13 Apr 2008

Periodontitis and human papillomavirus combined increase risk for tongue cancer

Persons with periodontitis who also are infected with human papillomavirus (HPV) are at increased risk of developing tongue cancer, new research conducted at the University at Buffalo School of Dental Medicine has shown.

7 Apr 2008

Replacing absent microRNAs could make tumors less invasive, more treatable

One group of small, non-coding RNA molecules could serve as a marker to improve cancer staging and may also be able to convert some advanced tumors to more treatable stages, report a University of Chicago-based research team in the April 1, 2008, issue of the journal Genes & Development.

1 Apr 2008

Increased hepcidin expression: A novel oncogenic signalling mechanism

Historically anaemia, which is associated with colorectal cancer, has been attributed to blood loss.

19 Mar 2008

Cruciferous vegetables may lower risk for breast cancer

When your mother told you to eat your vegetables it appears that maternal wisdom had a scientific basis.

10 Mar 2008

Discovery of family of genes linked to the development of liver cancer

An interdisciplinary team of researchers at Stony Brook University Medical Center has identified a family of genes linked to the development of liver cancer.

28 Feb 2008

Newly discovered ERK pathway proteins related to CagA induced disease

Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases, especially gastric cancer.

25 Feb 2008

New understanding of cancer initiation

Researchers at the University of Nebraska Medical Center (UNMC) in Omaha have assisted in a significant discovery - the understanding of a common mechanism of cancer initiation - that could result in better cancer assessment, prevention and detection.

7 Feb 2008

Discovery of novel molecular pattern linked to colon cancer prognosis

An international research team has identified a link between the expression patterns of a class of molecules called microRNAs and how a patient's colon cancer may progress.

29 Jan 2008

Acanthus ilicifolius plant may combat liver cancer

Liver cancer is the fifth most common cancer in the world with a poor prognosis. About three quarters of the cases of liver cancer are found in Southeast Asia, including China, Hong Kong, Taiwan, Korea, India, and Japan.

17 Jan 2008

New biomarker for predicting liver cancer spread and survival discovered

New research has shown that a unique pattern of microRNAs, small RNA molecules that regulate gene activity, can accurately predict whether liver cancer will spread and whether liver cancer patients will have shorter or longer survival, even patients with early stage disease.

7 Jan 2008

The science of cancer health disparities in racial/ethnic minorities and the medically underserved

The latest biological, clinical and social research behind how cancer affects different racial and ethnic groups will be the focus of the first American Association for Cancer Research conference on the topic, entitled "The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved."

21 Nov 2007