Cardiomyopathy News and Research

RSS

Cardiomyopathy is a group of diseases with primary, usually diffuse, involvement of the myocardium. The myocardial disease is not secondary to ischaemic, valvular, congenital or pericardial disease.

Final results from Alnylam’s ALN-TTR01 Phase I trial on TTR-mediated amyloidosis

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today final results from its completed Phase I clinical trial with ALN-TTR01, an RNAi therapeutic targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis.

11 May 2012

Ixmyelocel-T shows promise against progressive heart failure

An investigational therapy derived from a patient's own bone marrow stem cells improves heart function in some patients with progressive heart failure due to dilated cardiomyopathy (DCM), according to the results of a Phase 2a study presented today as a late-breaking clinical trial at the SCAI 2012 Scientific Sessions.

11 May 2012

Researchers discover location and effect of abnormal heart proteins

University of Guelph researchers have found the location and effect of abnormal heart proteins that can cause cardiac failure, a discovery that points to potential new ways to treat the most costly health problem in the world.

9 May 2012

Seattle Children's Hospital performs 100th heart transplant on 5-month-old baby

On Saturday, April 28, a 5-month-old baby received the 100th heart transplant performed at Seattle Children's Hospital, a significant milestone for him as well as the hospital's Heart Center and Heart Transplant Program teams.

7 May 2012

Reducing levels of SUN1 protein increases life span of mice with progeria, heart disease

Scientists have discovered that they can dramatically increase the life span of mice with progeria (premature ageing disease) and heart disease (caused by Emery-Dreifuss muscular dystrophy) by reducing levels of a protein called SUN1.

30 Apr 2012

First study to look at link between gender and mother's cardiac disease

Women with heart disease are more likely to give birth to female rather than male babies according to a new study presented today at the World Congress of Cardiology. The study found that three-quarters of the 216 children born to 200 pregnant women with diagnosed heart disease were female.

20 Apr 2012

LVHT more common in afro-Caribbean athletes

Left-ventricular hyper-trabeculation (LVHT) - a feature of certain cardiomyopathies (chronic disease of the heart muscle) - has been found to be more common in black, male athletes according to a new study presented today at the World Congress of Cardiology.

19 Apr 2012

Latest fad ‘feeding tube’ diet concerns experts

The New York Times reports that some women with upcoming weddings are opting for a calorie-restricted crash diet consisting of shakes siphoned through a medically implanted feeding tube. It is the so-called “K-E diet” that's given by Dr. Oliver R. Di Pietro in his clinic in Bay Harbor Islands, Fla.

18 Apr 2012

SMART Heart improves cardiovascular surgical outcomes

Two years ago, 57-year-old Allus Brown underwent a simultaneous heart-kidney transplant and spent months in and out of the hospital after battling dilated cardiomyopathy, a condition that enlarges and weakens the heart. Now fully recovered, Brown is still in and out of Northwestern Memorial Hospital's Bluhm Cardiovascular Institute each week. Only nowadays when he visits, he's laughing it up, playing board games, and sharing accounts of his own struggles with heart disease as part of the Bluhm Institute's new and innovative program, SMART Heart, stress management and recreational therapy for heart patients.

16 Apr 2012

Higher blood glucose levels may improve survival rates for heart failure patients with diabetes

Lowering glucose levels for people with diabetes is normally critical to improving health outcomes. But for those with heart failure, that might not always be the case, say UCLA researchers.

10 Apr 2012

RNA binding motif protein 20 regulates titin splicing

Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown.

2 Apr 2012

Cambridge Heart fourth quarter total revenue decreases to $557,000

Cambridge Heart, Inc., a developer of non-invasive diagnostic tests for cardiac disease, today reported results for its fourth quarter and full year ended December 31, 2011. Full financial statements and corresponding commentary can be found in the Company's Form 10-K, which will be filed with the Securities and Exchange Commission on March 30, 2012.

31 Mar 2012

Researchers identify genetic causes in nearly 1 in 5 patients with dilated cardiomyopathy

Researchers have identified genetic causes in nearly 1 in 5 patients who suffer a type of heart failure called dilated cardiomyopathy.

28 Mar 2012

CRT-D appropriate for patients with left ventricular dysfunction

Cardiac resynchronization therapy with defibrillators (CRT-D) is appropriate for patients who have left ventricular dysfunction and require chronic ventricular pacing, based on the findings of an observational study that being presented March 26 that the 61st annual American College of Cardiology (ACC) scientific session.

27 Mar 2012

New method to easily identify cause of rare diseases

Sanford Health Children's Research Center researcher, Kyle Roux, PhD, has revealed a new method of research that will allow the cause of disease—particularly rare diseases—to become more easily identified.

23 Mar 2012

New method for in vivo study of unknown selenium metabolism

Spanish and Danish researchers have developed a method for the in vivo study of the unknown metabolism of selenium, an essential element for living beings. The technique can help clarify whether or not it possesses the anti-tumour properties that have been attributed to it and yet have not been verified through clinical trials.

22 Mar 2012

Alnylam commences dosing in ALN-TTR02 Phase I clinical trial for TTR-mediated amyloidosis

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has initiated dosing in its Phase I clinical trial with ALN-TTR02, an RNAi therapeutic targeting the transthyretin (TTR) gene for the treatment of TTR-mediated amyloidosis (ATTR). The study is aimed at evaluating the safety and tolerability of ALN-TTR02 in healthy volunteers.

19 Mar 2012

Japan's MHLW provides reimbursement coverage for MTWA test

Cambridge Heart, Inc., a developer of non-invasive diagnostic tests for cardiac disease, today announced that its Microvolt T-Wave Alternans (MTWA) test received reimbursement coverage from Japan's Ministry of Health, Labor and Welfare (MHLW).

17 Mar 2012

New recovery protocol treats heart failure patients with LVADs

Some patients with advanced heart failure caused by cardiomyopathy, the deterioration of function of the heart muscle, are benefitting from a new recovery protocol at the University of Louisville and Jewish Hospital, a part of KentuckyOne Health.

13 Mar 2012

International effort to define ECG interpretation standards in athletes

On Feb. 13-14, the American Medical Society for Sports Medicine (AMSSM) partnered with the ESC Sports Cardiology Section, the PACES, other leading U.S. cardiologists, BJSM, and F-MARC in an effort to define ECG interpretation standards in athletes and develop a comprehensive online training module for physicians around the world to gain expertise in ECG interpretation and the proper evaluation of ECG abnormalities suggestive of a pathologic cardiovascular disorder.

22 Feb 2012