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Protein signaling in embryos is far more complex than previously thought

How cells in developing embryos communicate depends a great deal on context, according to scientists at Rice University.

2 Mar 2019

Researchers discover new and rare skeletal disease

Researchers at Karolinska Institutet in Sweden have discovered a new and rare skeletal disease. In a study published in the journal Nature Medicine they describe the molecular mechanism of the disease, in which small RNA molecules play a role that has never before been observed in a congenital human disease.

25 Feb 2019

Using CRISPR to regulate genes in the rat brain

Neuroscientists have used CRISPR/Cas9 genome editing technology to regulate genes in the rat brain. Described in eNeuro, this technique paves the way for researchers to probe genetic influences on brain health and disease in model organisms that more closely resemble human conditions.

From Society for Neuroscience 25 Feb 2019

Newly developed gene therapy helps decelerate aging process

Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer's disease, to name a few. This makes the need for anti-aging therapies all the more urgent. Now, Salk Institute researchers have developed a new gene therapy to help decelerate the aging process.

20 Feb 2019

Single CRISPR treatment can safely and stably correct genetic disease

Researchers at Duke University have shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes.

18 Feb 2019

CRISPR technology creates pluripotent stem cells that are 'invisible' to the immune system

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally "invisible" to the immune system, a feat of biological engineering that, in laboratory studies, prevented rejection of stem cell transplants.

18 Feb 2019

Researchers study animal venoms to identify new medicines for treating diseases

Animal venoms are the subject of study at research center based at the Butantan Institute in São Paulo. But in this case, the idea is not to find antidotes, but rather to use the properties of the venoms themselves to identify molecular targets of diseases and, armed with that knowledge, develop new compounds that can be used as medicines.

15 Feb 2019

Study discovers new therapy for aggressive blood cancer

Acute myeloid leukemia is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells.

13 Feb 2019

Vilcek Foundation prizes awarded to immigrants for their work on human biology and disease

The Vilcek Foundation is pleased to announce the winners of the 2019 Vilcek Foundation Prizes for Biomedical Science, awarded to immigrants who have made significant contributions to the field. Dr. Angelika Amon will receive the $100,000 Vilcek Prize, while Drs. Amit Choudhary, Jeanne T. Paz, and Mikhail G. Shapiro will each receive the $50,000 Vilcek Prize for Creative Promise.

8 Feb 2019

Mutations in folliculin gene affect embryo implantation

New information is unfolding on the genetic controls of an early turning point in pregnancy. As the tiny, dividing cell mass, the blastocyst, travels from the oviduct and lodges in the wall of the uterus, the cells must exit their pre-implantation state and be ready for post-implantation development.

7 Feb 2019

Promega signs license agreement with Broad Institute to access CRISPR-Cas9 technology

Promega announce non-exclusive license agreement with the Broad Institute of MIT and Harvard to sell tools and reagents for CRISPR-Cas9 gene editing.

From Promega Corporation 30 Jan 2019

Using bivalves as model organisms offers promising avenues for medical research

Shellfish like oysters and mussels have the potential to revolutionize human health research, according to a new paper in Developmental and Comparative Immunology.

30 Jan 2019

Megaphages detected in the intestinal tract of humans who eat high-fiber, low-fat diet

Viruses plague bacteria just as viruses like influenza plague humans. Some of the largest of these so-called bacteriophages have now been found in the human gut, where they periodically devastate bacteria just as seasonal outbreaks of flu lay humans low, according to a new study led by University of California, Berkeley, scientists.

29 Jan 2019

Gluten-free wheat can be produced for people with celiac disease by using gene editing

One to two per cent of the population has Celiac Disease (CD), an immune reaction to gluten. Wheat grains contain gluten, a mixture of glutenin and gliadin proteins, which build a network that gives wheat bread its unique properties and quality.

28 Jan 2019

Researchers identify new peptide that helps lateral roots to grow with right spacing

How do plants space out their roots? A Japanese research team has identified a peptide and its receptor that help lateral roots to grow with the right spacing.

21 Jan 2019

Researchers use gene-editing tool CRISPR/Cas9 to limit impact of parasitic diseases

For the first time, researchers at the George Washington University, together with colleagues at institutes in Thailand, Australia, the U.K. and the Netherlands, and more, have successfully used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for schistosomiasis and for liver fluke infection, which can cause a diverse spectrum of human disease including bile duct cancer.

16 Jan 2019

CRISPR-Cas9 circular permutants can sense and respond to viral proteases

Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse applications beyond simple DNA cutting, such as base editing and epigenetic modifications.

11 Jan 2019