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Novel method can edit genes with substantially fewer errors

Gene therapy is an emerging strategy to treat diseases caused by genetic abnormalities. One form of gene therapy involves the direct repair of a defective gene, using genome-editing technology such as CRISPR-Cas9. Despite its therapeutic potential, genome editing can also introduce unwanted and potentially harmful genetic errors that limit its clinical feasibility.

5 Feb 2018

UCSF researchers find new way to attack common drivers of 'undruggable' cancers

Cancer researchers have made great strides in developing targeted therapies that treat the specific genetic mutations underlying a patient's cancer.

24 Jan 2018

Chinese researchers develop multifunctional vehicle to transport gene therapeutics

Gene editing is one of the hottest topics in cancer research. A Chinese research team has now developed a gold-nanoparticle-based multifunctional vehicle to transport the "gene scissors" to the tumor cell genome.

22 Jan 2018

Research provides insights into mechanisms governing healthy longevity

Keio University Global Research Institute, Tokyo publishes the January 2018 issue of KGRI Research Frontiers that includes researcher video profiles of Keio University researchers and research highlights from high impact publications including 'Regenerative medicine needs collaboration in and out of science in order to face current and future challenges; ‘Does eating fish protect you from depression?’; ‘Insights into the molecular mechanisms leading to kidney dysfunction in diabetic patients’; and ‘Ageing to 100 and beyond: Insights from demographic, phenotypic and genetic studies.

12 Jan 2018

Researchers discover genetic mechanism for resistance to immunotherapy drugs

An urgent question for cancer scientists is why immunotherapy achieves dramatic results in some cases but doesn't help most patients.

5 Jan 2018

Salk scientists find simpler way to derive functioning cardiac cells from stem cells

The process by which embryonic stem cells develop into heart cells is a complex process involving the precisely timed activation of several molecular pathways and at least 200 genes.

22 Dec 2017

Researchers use a gene-editing complex to preserve hearing in animal model of progressive deafness

Researchers have developed a CRISPR-Cas9 gene-editing complex that can be delivered directly into hair cells of the inner ear to prevent hearing loss.

21 Dec 2017

Genome editing approach prevents progressive hearing loss in animals

Using molecular scissors wrapped in a greasy delivery package, researchers have disrupted a gene variant that leads to deafness in mice.

20 Dec 2017

Gene editing shows promise to help people at risk of hearing loss

Gene editing could someday help people at risk of hearing loss from genetic mutations, according to research by a new Rice University faculty member.

20 Dec 2017

Study shows vital role for maternally inherited gene in embryonic development

A new study indicates an essential role for a maternally inherited gene in embryonic development. The study found that zebrafish that failed to inherit specific genetic instructions from mom developed fatal defects earlier in development, even if the fish could make their own version of the gene.

18 Dec 2017

Researchers generate 3D cell cultures to investigate mechanisms of drug resistance in breast cancer

An international research team headed by the University of Bern and the Netherlands Cancer Institute has developed 3D cell cultures in which genes can be specifically modified. They allow the study of genes that may cause therapy resistance in breast cancer.

11 Dec 2017

UT Southwestern researchers develop improved gene-editing technique to correct DMD mutations

Regenerative medicine researchers at UT Southwestern Medical Center developed an improved and simplified gene-editing technique using CRISPR/Cas9 tools to correct a common mutation that causes Duchenne muscular dystrophy.

30 Nov 2017

Using AFM to characterize cancer cells

An interview with Dr. Jim Gimzewski, UCLA conducted by April Cashin-Garbutt, MA (Cantab).

From Bruker Nano Surfaces and Metrology 28 Nov 2017

Study finds unexpected new drug target for acute myeloid leukemia

A study has found an unexpected new drug target for acute myeloid leukemia (AML) that could open new avenues to develop effective treatments against this potentially lethal disease.

27 Nov 2017

CRISPR shows potential to reduce diseases spread by mosquitoes

Research at the University of California, Riverside, have shown that it is possible for transgenic mosquitos to stably express the Cas9 enzyme in their germline. Cas9 addition will allow the utilization of the CRISPR gene editing tool to carry out efficient and highly targeted changes to the DNA of the mosquitoes.

16 Nov 2017

Researchers visualize mechanism of CRISPR-Cas9 genetic-engineering technique

Researchers at Kanazawa University and the University of Tokyo report in Nature Communications the visualization of the dynamics of ‘molecular scissors’ — the main mechanism of the CRISPR-Cas9 genetic-engineering technique.

15 Nov 2017

Nanoparticles carrying CRISPR gene editing tools for genetic modifications

Researchers from MIT have now developed nanoparticles that could carry CRISPR genetic editing systems deep within the cells and perform their functions on the DNA. The paper was published in the November issue of Nature Biotechnology.

14 Nov 2017

UCR researchers develop transgenic mosquitoes to help reduce spread of infectious diseases

Researchers at the University of California, Riverside have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9 will enable the use of the CRISPR gene editing tool to make efficient, targeted changes to the mosquitoes' DNA.

14 Nov 2017

Advances in genetic and stem cell techniques help identify therapeutic targets for neurological disorders

Research released today highlights advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and addiction.

13 Nov 2017

New model could provide understanding of how HIV infection damages the brain

HIV infects certain cells in the brain called microglia, and infected microglia release toxic and inflammatory molecules that can impair or kill surrounding neurons.

8 Nov 2017