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Conference to focus on preventing and reversing consequences of sickle cell disease

Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American Physiological Society, will explore SCD- the world's most prevalent single-gene mutation disease-; and new research on preventing and reversing its deadly consequences.

1 Nov 2017

New gene drive approach helps pinpoint combination therapies against fungal pathogens

Candida albicans is a notorious human fungal pathogen that causes thrush and serious systemic infections. Opportunistic C. albicans fungi, which often live inconspicuously in the normal flora of human skin and gut, can switch from their harmless stealth mode to become aggressive pathogens, especially in people whose immune systems are already compromised by pre-existing diseases or harsh drug therapies.

30 Oct 2017

Penn study sheds light on genetic cause of early hearing loss

From the moment a baby is born, they are put through a battery of screenings to test for all sorts of characteristics, which includes the sense of hearing.

26 Oct 2017

New enzyme may one day enable genome surgery that erases harmful mutations

DNA editing just got a sharp, new pencil. Researchers have built an enzyme that can perform a previously impossible DNA swap, directly changing the DNA base pair from an A•T to a G•C.

26 Oct 2017

CRISPRy bacon ! Genetically modified leaner low-fat pigs

Genetically modified leaner pigs are on the cards soon. Researchers in china used the gene-editing technology, CRISPR, to create pigs that are less fatty and leaner with more muscle. This could mean genetically modified bacon on the plates.

24 Oct 2017

Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing disease.

24 Oct 2017

Study identifies predictors of poor outcomes in Duchenne muscular dystrophy patients

A new study from UT Southwestern suggests that more people with Duchenne muscular dystrophy could live longer by identifying and more aggressively treating patients with certain risk factors.

20 Oct 2017

Researchers identify strategies to mitigate disturbed axonal transport in ALS patients

A team of researchers at VIB and KU Leuven used stem cell technology to generate motor neurons from ALS patients carrying mutations in FUS. They found disturbed axonal transport in these motor neurons, but also identified genetic and pharmacological strategies that mitigate this defect.

17 Oct 2017

MIT researchers develop new technique to screen for genes that protect against diseases

Using a modified version of the CRISPR genome-editing system, MIT researchers have developed a new way to screen for genes that protect against specific diseases.

12 Oct 2017

Study documents gene mutation as cause of cancer form in the liver

There is no effective treatment for the cancer form found in the liver called fibrolamellar hepatocellular carcinoma, which is mainly found among children and young people.

12 Oct 2017

Genetic discovery provides strong lead for future research on male contraception

When it comes to birth control, many males turn to two options: condoms or vasectomies. While the two choices are effective, both methods merely focus on blocking the transportation of sperm.

10 Oct 2017

TTUHSC El Paso researcher receives $420,000 grant to study mosquito-borne Zika virus

Haoquan Wu, Ph.D., associate professor in the Paul L. Foster School of Medicine, has received a two-year, $420,000 grant from the National Institute of Allergy and Infectious Disease to study the mosquito-borne virus Zika.

10 Oct 2017

New microcapsules represent promising vectors for application of genome-editing tools

Researchers from Tomsk Polytechnic University jointly with their colleagues from St. Petersburg, Hamburg and London have conducted a study in the course of which it was found out that polymer and hybrid silica-coated microcapsules are more efficient in genome-editing when applying CRISPR-Cas9 system.

6 Oct 2017

Study uses ferret model to elucidate key mechanisms for gyrus formation

The human brain is highly developed with higher functions compared to other animals, thanks to which humans are believed to have acquired special abilities. One of the important factors considered to contribute to the development of the brain is the gyrus, the fold on the cerebral cortex surface.

5 Oct 2017

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

Scientists at the University of California, Berkeley, have engineered a new way to deliver CRISPR-Cas9 gene-editing technology inside cells and have demonstrated in mice that the technology can repair the mutation that causes Duchenne muscular dystrophy, a severe muscle-wasting disease.

4 Oct 2017

“Chemical surgery” on embryos to free them of a gene causing thalassemia

A team of Chinese researchers have for the first time “mended” defective embryos using chemical surgery to free them of a faulty gene that leads to beta thalassemia. Until now this defect was found to be incorrigible caused due to a single misspelling in the DNA code. Beta thalassemia is a dreaded blood disorder wherein the child is unable to make healthy blood needing blood transfusions on a regular basis. The study was published this week in the journal Protein and Cell.

2 Oct 2017

Cas9 News and Research

Conference to focus on preventing and reversing consequences of sickle cell disease

New gene drive approach helps pinpoint combination therapies against fungal pathogens

Penn study sheds light on genetic cause of early hearing loss

New enzyme may one day enable genome surgery that erases harmful mutations

CRISPRy bacon ! Genetically modified leaner low-fat pigs

Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

Study identifies predictors of poor outcomes in Duchenne muscular dystrophy patients

Researchers identify strategies to mitigate disturbed axonal transport in ALS patients

MIT researchers develop new technique to screen for genes that protect against diseases

Study documents gene mutation as cause of cancer form in the liver

Genetic discovery provides strong lead for future research on male contraception

TTUHSC El Paso researcher receives $420,000 grant to study mosquito-borne Zika virus

New microcapsules represent promising vectors for application of genome-editing tools

Study uses ferret model to elucidate key mechanisms for gyrus formation

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

“Chemical surgery” on embryos to free them of a gene causing thalassemia

Drug approved to treat parasitic infections also exerts anti-tumor effect on EOC cells

Gene editing technique helps uncover potential new drug targets for KRAS-driven cancers

Understanding molecular mechanisms and metabolic pathways of yeast for drug discovery

Scientists use genome editing to understand role of a gene key to human embryonic development

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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