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Method to comprehensively characterize human embryonic stem cell lines and iPS cell lines

Ever since researchers devised a recipe for turning adult cells into cells that look and act like embryonic stem cells, there has been lingering doubt in the field about just how close to embryonic stem cells each of those cell lines really is at a molecular and functional level. Now, researchers reporting in the February 4th issue of the journal Cell, a Cell Press publication, have developed a systematic way to lay those doubts about quality to rest.

4 Feb 2011

How body's first line of defence distinguishes between microbes and own structures

This week, the highly-respected US Academy of Sciences journal (PNAS) published an article describing how the first line of defence of the human immune system distinguishes between microbes and the body's own structures.

4 Feb 2011

New 'skin gun' treats burns with stem cells

A revolutionary new "skin gun" developed to treat burns could be the latest in a remarkable string of stem-cell breakthroughs poised to change the face of medicine, says Emerging Healthcare Solutions President and CEO Cindy Morrissey.

4 Feb 2011

Research unmasks long sought stem cell origin of carcinoma

A constellation of different stem cell populations within our skin help it to cope with normal wear and tear. By constantly proliferating, the stem cells allow skin to replenish itself, allowing each cell to be replaced by a new one about once a month. But the normal cycle of division and death within one or more of these stem cell types can sometimes be derailed by genetic mishaps. Such events are believed to spawn carcinomas and other deadly skin cancers, which are the mostly frequently diagnosed cancers in the United States.

4 Feb 2011

Researchers identify regulatory defect that drives lupus

Researchers at Dana-Farber Cancer Institute in Cambridge, Mass., in collaboration with Jackson Laboratory scientists, have identified a regulatory defect that drives lupus.

4 Feb 2011

Cholesterol efflux capacity may protect against heart disease: Study

The discovery that high levels of high-density lipoprotein cholesterol are associated with reduced risk of cardiovascular disease has fostered intensive research to modify HDL levels for therapeutic gain. However, recent findings have called into question the notion that pharmacologic increases in HDL cholesterol levels are necessarily beneficial to patients.

4 Feb 2011

New discovery: miR-429 regulatory RNA may be effective in fighting ovarian cancer

Cancer researchers have discovered that a type of regulatory RNA may be effective in fighting ovarian cancer. Ovarian cancer isn't typically discovered until it's in the advanced stages, where it is already spreading to other organs and is very difficult to fight with chemotherapy.

4 Feb 2011

Data generated on Ion Torrent PGM sequencer to be presented at AGBT

Life Technologies Corporation, today announced that just six weeks following the launch of the Ion Torrent PGM sequencer, independent researchers will present data they generated with the system at the annual Advances in Genome Biology and Technology (AGBT) conference.

4 Feb 2011

Scientists reprogram marrow cells from patient with chronic myeloid leukemia

By coaxing healthy and diseased human bone marrow to become embryonic-like stem cells, a team of Wisconsin scientists has laid the groundwork for observing the onset of the blood cancer leukemia in the laboratory dish.

4 Feb 2011

Treg therapy ensures success of hematopoietic stem cell transplantation, without triggering GVHD

For blood cancer patients at high risk of relapse, hematopoietic stem cell transplantation (HSCT), the transplantation of blood-forming stem cells, is one of best options for treatment and a potential cure. Unfortunately, the most common complication of HSCT is graft-versus-host disease (GVHD), a serious and often deadly post-transplant complication that occurs when the newly transplanted donor cells recognize the recipient's own cells as foreign and react by attacking the cells in the patient's body.

4 Feb 2011

New study finds link between mealtime family interactions and children's health

The amount of time families spend eating meals together has been linked to the health and well-being of children and teens, with families who eat together regularly reporting declines in substance abuse, eating disorders, and unhealthy weight in their children. Now, a new study that looks at children with asthma has found that the quality of family interactions during mealtime affected the children's health.

4 Feb 2011

Cell signaling hormone boosts immune response to clear HIV-like infection

Australian scientists have successfully cleared a HIV-like infection from mice by boosting the function of cells vital to the immune response.

4 Feb 2011

New study provides insight into mechanism behind breast cancer mutation

A new study sheds light on why individuals who inherit a particular family of mutations have a high risk of developing a very aggressive form of breast cancer. The research, published by Cell Press on February 4th in the journal Cell Stem Cell, shows that breast tissue cells from these individuals make abnormal cell-fate decisions even before cancer develops and provides exciting new insights into the mechanisms behind one of the most lethal types of breast cancer.

4 Feb 2011

Stem cells delivered intranasally improve motor function in Parkinson's disease

Stem cells, delivered intranasally, were found to substantially improve motor function in Parkinson's disease in a study co-authored by William H. Frey II, Ph.D, Director of the Alzheimer's Research Center, part of HealthPartners Research Foundation. Frey collaborated with Lusine Danielyan, MD, of University Hospital of Tubingen in Germany.

4 Feb 2011

JDRF, Eli Lilly sign agreement to fund type 1 diabetes research for re-generative medicine

Eli Lilly and Company and the Juvenile Diabetes Research Foundation today announced that they have signed an agreement to fund early-stage research that could enable patients with type 1 diabetes to regenerate insulin-producing cells destroyed by the disease.

4 Feb 2011

Scientists unravel mystery about how new tumors in individuals with breast cancer take root

In a discovery that may lead to a new treatment for breast cancer that has spread to the bone, a Princeton University research team has unraveled a mystery about how these tumors take root.

4 Feb 2011

FDA approves Hospira's topotecan for SCLC

Hospira, Inc., the world leader in generic injectable pharmaceuticals, today announced U.S. Food and Drug Administration (FDA) approval of Topotecan Injection, the first solution formulation of the oncology drug approved in the United States.

3 Feb 2011

Ceregene initiates enrollment and dosing in CERE-120 Phase 2b trial for Parkinson's disease

Ceregene, a biopharmaceutical company, announced today that it is progressing with enrollment and dosing in its CERE-120 Phase 2b multi-center, sham-surgery, double-blinded controlled trial in Parkinson's disease.

3 Feb 2011

ZIOPHARM prices underwritten public offering of 9,600,000 shares of common stock

ZIOPHARM Oncology, today announced the pricing of an underwritten public offering of 9,600,000 shares of its common stock at a price to the public of $5.75 per share.

3 Feb 2011

AVEO receives USAN, WHO generic name approval for ficlatuzumab

AVEO Pharmaceuticals, Inc. today announced that the United States Adopted Names (USAN) Council, in consultation with the World Health Organization (WHO) International Nonproprietary Names Expert Committee, has approved the use of the nonproprietary generic name "ficlatuzumab" (pronounced fye" kla tue' zue mab) for AV-299, a potent, functional anti-HGF/c-MET antibody internally discovered at AVEO.

3 Feb 2011

Cell News and Research

Method to comprehensively characterize human embryonic stem cell lines and iPS cell lines

How body's first line of defence distinguishes between microbes and own structures

New 'skin gun' treats burns with stem cells

Research unmasks long sought stem cell origin of carcinoma

Researchers identify regulatory defect that drives lupus

Cholesterol efflux capacity may protect against heart disease: Study

New discovery: miR-429 regulatory RNA may be effective in fighting ovarian cancer

Data generated on Ion Torrent PGM sequencer to be presented at AGBT

Scientists reprogram marrow cells from patient with chronic myeloid leukemia

Treg therapy ensures success of hematopoietic stem cell transplantation, without triggering GVHD

New study finds link between mealtime family interactions and children's health

Cell signaling hormone boosts immune response to clear HIV-like infection

New study provides insight into mechanism behind breast cancer mutation

Stem cells delivered intranasally improve motor function in Parkinson's disease

JDRF, Eli Lilly sign agreement to fund type 1 diabetes research for re-generative medicine

Scientists unravel mystery about how new tumors in individuals with breast cancer take root

FDA approves Hospira's topotecan for SCLC

Ceregene initiates enrollment and dosing in CERE-120 Phase 2b trial for Parkinson's disease

ZIOPHARM prices underwritten public offering of 9,600,000 shares of common stock

AVEO receives USAN, WHO generic name approval for ficlatuzumab

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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