Cell Adhesion News and Research

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Cell adhesion essential for cells to survive stress

Cell-to-cell contacts are necessary for the survival of human cells under protein-damaging conditions and stress.

16 Jan 2020

Interplay between relaxin and Wnt signaling has positive effects on aging heart

As a healthy heart ages, it becomes more susceptible to cardiovascular diseases. Though researchers have discovered that relaxin, an insulin-like hormone, suppresses atrial fibrillation (AF), inflammation, and fibrosis in aged rats, the underlying mechanisms of these benefits are still unknown.

7 Jan 2020

Researchers investigate NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies

The cover for issue 63 of Oncotarget features Figure 6, "Inverse relationship between ETV7 and SERPINE1 in OSCC," by Salameti, et al.

4 Dec 2019

Inhibition of a protease could improve the treatment of IBD, study shows

Scientists at the Centro Nacional de Investigaciones Cardiovasculares and the Centro de Investigaciones Biológicas of the Consejo Superior de Investigaciones Científicas have identified the protease MT1-MMP as a possible future target for drugs to treat inflammatory bowel disease.

3 Dec 2019

CD44 protein helps identify mother cells responsible for aggressive nature of neuroblastoma

A group of researchers from the University of Seville and the Seville Biomedicine Institute (Instituto de Biomedicina de Sevilla - IBiS) has published a study in which they determine that a protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old.

27 Nov 2019

Study shows how fiber spacing could control cell sticking

Researchers from the Mechanobiology Institute at the National University of Singapore have shown that cells can attach to the fibrous protein meshwork that surrounds them only if the fibers are spaced close enough.

26 Nov 2019

Blocking a molecule could delay the progression of multiple sclerosis

Over 77,000 Canadians are living with multiple sclerosis, a disease whose causes still remain unknown. Presently, they have no hope for a cure.

14 Nov 2019

Genes linked to autism spectrum disorder may play role in eye movements

Researchers studying zebrafish have found that genes linked to autism spectrum disorder and other developmental brain abnormalities may be playing a role in people who cannot control their eye movements.

4 Nov 2019

GW researchers show connection between bacteria in the microbiome and colon cancer

A mutant protein found in humans with colon cancer blocks a pathway that regulates proliferation and expansion of cells, increasing amounts of bacterial species associated with the development of colon cancer.

4 Oct 2019

New method for single-step fabrication of spatially functionalized scaffolds

Organs, muscles and bones are composed of multiple types of cells and tissues that are carefully organized to carry out a specific function.

30 Sep 2019

Using everyday materials as tissue scaffolds

As the global demand for tissue and organ transplants significantly outstrips supply, tissue engineering might provide a potential solution. But one of the significant challenges in tissue engineering is growing tissue in 3D, and the scaffolds used to position cells to develop tissue-specific functions are often challenging or prohibitively expensive to develop.

17 Sep 2019

Insulin drug could treat glioblastoma

A research team from the University of Georgia's Regenerative Bioscience Center has found that a compound molecule used for drug delivery of insulin could be used to treat glioblastoma, an aggressive, usually fatal form of brain cancer.

12 Sep 2019

Cell adhesion protein promotes metastasis in breast cancer, study reveals

Researchers at the Johns Hopkins Kimmel Cancer Center discovered that a cell adhesion protein, E-cadherin, allows breast cancer cells to survive as they travel through the body and form new tumors, a process termed metastasis.

From Johns Hopkins Medicine 11 Sep 2019

Existing drug could be used to treat glioblastoma

11 Sep 2019

Protein implicated in neuron growth and cell adhesion appears crucial for pain sensitization

Researchers from Japan's Osaka University have made an important leap in our understanding of how chronic pain conditions develop.

20 Aug 2019

Ultrasensitive method for direct detection of circulating tumor cells in blood

Tumor cells circulating in blood are markers for the early detection and prognosis of cancer. However, detection of these cells is challenging because of their scarcity.

8 Aug 2019

PDIA1 enzyme levels could help diagnose individuals’ predisposition to cardiovascular disease

Measuring the blood plasma levels of an enzyme called PDIA1 could one day become a method of diagnosing a person's predisposition to cardiovascular disease even if they are healthy, i.e., not obese, diabetic or a smoker, and with normal cholesterol.

20 May 2019

Walnut consumption could change gene expression in pathologically-confirmed breast cancers

New research from Marshall University links walnut consumption as a contributing factor that could suppress growth and survival of breast cancers.

29 Mar 2019

Tumor biomarker EpCAM shown to be promising target for cancer immunotherapy

Researchers have shown that cancer immunotherapy targeting the tumor biomarker epithelial cell adhesion molecule is safe and nontoxic in mice and can significantly delay tumor formation and growth.

28 Mar 2019

Researchers unravel biomechanics of Ebola virus-host cell adhesion

It was recently reported that the number of Ebola cases in the Democratic Republic of Congo has surpassed 1,000, making it the second-worst outbreak in history after the 2014 outbreak in West Africa in which 29,000 people were infected and more than 11,000 died.

27 Mar 2019