Cell Death News and Research

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Quark Pharmaceuticals' siRNAs examined alone and in xombination with chemotherapy

Quark Pharmaceuticals, Inc. has announced that the journal Cancer Research published results on efficacy of siRNA targeting its proprietary target gene against non-small cell lung cancer (NSCLC) in the edition dated October 1, 2008.

12 Oct 2008

On the trail of a targeted therapy for blood cancer

Investigators from the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine are focusing on a family of blood proteins that they hope holds a key to decreasing the toxic effects of chemotherapy in children and adults.

12 Oct 2008

Ginkgo biloba may prevent brain cell damage after a stroke

Working with genetically engineered mice, researchers at Johns Hopkins have shown that daily doses of a standardized extract from the leaves of the ginkgo tree can prevent or reduce brain damage after an induced stroke.

12 Oct 2008

Eli Lilly starts second global phase III trial of investigational Alzheimer's disease compound

Eli Lilly and Company today announced it will begin enrolling patients in a second Phase III study of LY450139, a gamma-secretase inhibitor being investigated as a potential treatment to delay the progression of mild to moderate Alzheimer's disease.

2 Oct 2008

Multifunctional polymer nanoparticles pass critical in vivo test

In an effort to overcome the drug resistance that often occurs in cancer, a team of investigators has developed a nanoparticle made of a blend of polymers that first releases a powerful anticancer drug and then delivers an agent that tricks a drug-resistant cell into committing suicide. Now, tests in mice with human breast cancer have shown that these blended nanoparticles are effective in maintaining high levels of both drugs in the vicinity of tumors.

28 Sep 2008

Sun exposure may have an anti-melanoma effect

Italian researchers have found a link between vitamin D and the risk of developing a melanoma and they say that individuals with certain variants in a vitamin D-related gene, called BsmI, may be at an increased risk of developing melanoma.

22 Sep 2008

Study identifies immune response that enables TB bacteria to multiply, provides new target for TB drugs

Researchers have identified an immune system response to tuberculosis that enables TB bacteria to spread through the lungs, providing a new target for TB drug development, according to a study published Sunday in Nature Immunology, AFP/Washington Times reports.

16 Sep 2008

Scientists identify ependymoma genes

Scientists at The University of Nottingham have isolated three important genes involved in the development of a type of childhood brain cancer. The breakthrough is revealed in a study published in the British Journal of Cancer.

15 Sep 2008

Newly discovered molecule promises better treatments for heart attacks, heart surgery

Scientists have discovered a compound that could lead to new treatments for heart attacks as well as methods to protect hearts during open heart surgery and other situations in which blood flow to the heart is interrupted.

11 Sep 2008

New ependymoma genes identified

Scientists have isolated three important genes involved in the development of a type of childhood brain cancer- reveals a study published in the British Journal of Cancer.

10 Sep 2008

New technique in blood analysis may speed diagnosis of heart attacks

Someday doctors may be able to use a blood test to confirm within minutes, instead of hours, if a patient is having a heart attack, allowing more rapid treatment that could limit damage to heart muscle.

9 Sep 2008

'Black sheep protein' key to cancer cell death

A neglected member of an important family of proteins could boost the effectiveness of an exciting new group of cancer drugs - reveals a study in Cancer Cell.

8 Sep 2008

Unsuccessful drug against anxiety opens a novel gateway for the treatment of cancer

According a new study, unsatisfying drug for anxiety reveals scientists a promising novel anti-cancer drug target.

4 Sep 2008

Oxidative stress: mechanism of cell death clarified

Dr. Marcus Conrad of the Institute of Clinical Molecular Biology and Tumor Genetics at the Helmholtz Zentrum Munchen has decrypted the molecular mechanism through which the death of cells is caused by oxidative stress.

3 Sep 2008

New discovery on growth factor - breakthrough for cancer research

A research team at the Ludwig Institute and Uppsala University has discovered an entirely new signal path for a growth factor that is of crucial importance for the survival and growth of cancer cells.

2 Sep 2008

The effects of A2 inhibitor Darapladib on human coronary athlerosclerotic plaque

A twelve month study of treatment with darapladib concluded that,Lp-PLA2 inhibition with darapladib prevented necrotic core expansion, a key determinant of plaque vulnerability.

2 Sep 2008

Why transplanted insulin cells die

New research can enhance survival of islets transplants and improve treatment of type 1 diabetes. Transplantation of insulin-producing cell islets, so-called islets of langerhans is an appealing strategy for treatment of type 1 diabetes. But it turns out that these are short-lived, and the procedure needs to be repeated.

28 Aug 2008