Cell Metabolism News and Research

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Global heartbeat control suggests therapy for beating heart failure

Keeping a healthy heart beating requires the production of a constant supply of energy, a feat depending on the coordination of several genetic programs.

9 May 2007

Plant chemical harmine fights diabetes in mice

After screening hundreds of compounds for their effects on fat development, researchers have discovered that an ingredient found in some plants fights diabetes in mice without some of the side effects attributed to other antidiabetes drugs.

9 May 2007

Study provides better understanding of how to treat individuals affected by copper imbalances

Copper is an essential part of our lives. From copper pipes and wires - to important copper-containing proteins in the body, copper is necessary for healthy growth and neurological development.

2 May 2007

Important new discovery in metabolomics

St. Jude investigators have mapped out many of the dynamic genetic and biochemical changes that make up a cell's response to a shortage of a molecule called Coenzyme A (CoA), a key player in metabolism.

27 Apr 2007

Researchers identify new player in the 'fat from food' game

UCLA investigators have identified a new molecule that may help regulate the delivery of fats to cells for energy and storage.

4 Apr 2007

Scientists identify new molecule that may help regulate the delivery of fats to cells

Published in the April issue of the journal Cell Metabolism, the finding could lead to a better understanding of how we utilize fats from the foods we eat.

4 Apr 2007

New 'platform' for processing dietary fat discovered

A new "platform" with a crucial role in the body's ability to process and take up fat from the diet has been found, according to a report in the April issue of the journal Cell Metabolism, published by Cell Press.

3 Apr 2007

Researchers discover factor that controls blood sugar's manufacture in a novel way

Researchers have discovered a factor that controls blood sugar's manufacture in a novel way: by limiting the supply of its building blocks. The findings are reported in the April issue of the journal Cell Metabolism, published by Cell Press.

3 Apr 2007

Researchers spot molecular player in insulin resistance and type 2 diabetes

Scientists at Weill Cornell Medical College have identified a protein called Rab10 as an important partner in the insulin-mediated uptake of glucose by cells, opening the way to potential new drug targets for the prevention and treatment of type 2 diabetes.

3 Apr 2007

Regulator of cholesterol production identified

By first probing the way primitive yeast make cholesterol, a team of scientists has discovered a long-sought protein whose human counterpart controls cholesterol production and potentially drug metabolism.

20 Feb 2007

Power-boosting signal in muscle declines with age

As people age, they may have to exercise even harder to get the benefits afforded to younger folk. That's the suggestion of a report in the February issue of the journal Cell Metabolism, showing that a signal that gives muscles a kind of metabolic boost in response to exercise is blunted in older animals.

6 Feb 2007

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A single protein in brain cells may act as a linchpin in the body's weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, University of Michigan Medical School researchers report.

29 Jan 2007

A central thermogenic-like mechanism in feeding regulation

During periods of fasting, brain cells responsible for stimulating the appetite make sure that you stay hungry.

2 Jan 2007

Researchers uncover new way in which the aging process is linked to DNA damage

Researchers have uncovered a new way in which the aging process is linked to DNA damage--which occurs normally as a result of cell metabolism and environmental influences--and the various ways in which cells repair that damage.

23 Oct 2006

Scientists discover how brain turns on system designed to protect nerve cells from toxic "free radicals"

Scientists at Dana-Farber Cancer Institute report they have found how the brain turns on a system designed to protect its nerve cells from toxic "free radicals," a waste product of cell metabolism that has been implicated in some degenerative brain diseases, heart attacks, strokes, cancer, and aging.

20 Oct 2006

PGC-1 alpha implicated in Huntington's disease neurodegeneration

A metabolic disorder underlies the brain effects found in those with Huntington's disease, researchers report in an advance article publishing online October 19, 2006. The article will appear in the November 2006 issue of the journal Cell Metabolism, published by Cell Press.

20 Oct 2006

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose function was previously unknown-serves as a key regulator of a lipid signaling network that contributes to cancer," said Benjamin F. Cravatt, a Scripps Research professor and a member of its Skaggs Institute for Chemical Biology who led the study.

20 Oct 2006

Cell Metabolism News and Research

Global heartbeat control suggests therapy for beating heart failure

Plant chemical harmine fights diabetes in mice

Study provides better understanding of how to treat individuals affected by copper imbalances

Important new discovery in metabolomics

Researchers identify new player in the 'fat from food' game

Scientists identify new molecule that may help regulate the delivery of fats to cells

New 'platform' for processing dietary fat discovered

Researchers discover factor that controls blood sugar's manufacture in a novel way

Researchers spot molecular player in insulin resistance and type 2 diabetes

Regulator of cholesterol production identified

Power-boosting signal in muscle declines with age

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A central thermogenic-like mechanism in feeding regulation

Researchers uncover new way in which the aging process is linked to DNA damage

Scientists discover how brain turns on system designed to protect nerve cells from toxic "free radicals"

PGC-1 alpha implicated in Huntington's disease neurodegeneration

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

Metabolic syndrome may be treatable thanks to a newly discovered role for a regulatory gene

Researchers discover how genes and diet interact to cause birth defects

The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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