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Scientists find key step in a signaling pathway that helps orchestrate embryonic development

The study, reported in Nature (Oct. 13, 2005), focuses on the Hedgehog family of signaling molecules, which play a central role in directing development of the early embryo's growth and spatial plan, as well as its later organ and limb development. Defects in Hedgehog signaling are a significant cause of some birth defects and cancers.

25 Oct 2005

New model important step toward understanding the molecular basis of cell membrane mechanics

A human red blood cell is a dimpled ballerina, ceaselessly spinning, tumbling, bending, and squeezing through openings narrower than its width to dispense life-giving oxygen to every corner of the body.

24 Oct 2005

Blocking a signaling lipid can keep nerves from developing and may even cause neurons to die

Blocking a signaling lipid can keep nerves from developing the arm-like extensions they need to wire the body and may even cause neurons to die, researchers have found.

24 Oct 2005

Research has important implications for autism

New research from Melbourne's Howard Florey Institute helps to explain why children with autism spectrum disorders (autism) have problem-solving difficulties.

24 Oct 2005

Possible new directions for treatments for addiction to cocaine

Cocaine causes specific alterations in the brain's circuitry at a genetic level, including short-term changes that result in a high from the cocaine, as well as long-term changes seen in addiction, researchers from UT Southwestern Medical Center have found.

23 Oct 2005

Menin is a key player in the development of some forms of acute leukemia

Tumor-suppressor proteins work to inhibit tumor growth in our bodies and when they win, they spare us a battle with cancer. But one such protein, menin, appears to have a split personality.

20 Oct 2005

Discovery of a new kind of messenger RNA molecule

Researchers at Cold Spring Harbor Laboratory have discovered a new kind of messenger RNA molecule that is converted from non-protein coding status to protein coding status in response to cellular stress such as viral infection.

20 Oct 2005

Spliceosome crucial for processing non-coding RNA

The discovery in 1977 that the coding regions of a gene could appear in separate segments along the DNA won the 1993 Nobel Prize in Physiology or Medicine for Richard J. Roberts and Phillip A. Sharp. The active segments of a gene were termed exons, separated from each other within the gene by inactive introns.

20 Oct 2005

Newly discovered role of MECP2 gene in Rett Syndrome

Huda Zoghbi, of Baylor College of Medicine and the Howard Hughes Medical Institute and Juan Young, also of Baylor and colleagues report in the online Early Edition of the Proceedings of the National Academy of Science, posted the week of October 17, 2005, that the Rett Syndrome gene, MECP2, regulates RNA splicing.

18 Oct 2005

Researchers shed light on a key molecular switch in T helper cells

Defects in immune system cells called T helper cells may lead to diseases characterized by a faulty inflammatory response such as autoimmunity and asthma. Understanding the molecular steps involved in how T helper cells mature may help researchers develop treatments for these diseases.

17 Oct 2005

Chromosomes in the nucleus of the cell carry the material of heredity, or genes

Abnormal cell division that yields cells with an extra set of chromosomes can initiate the development of tumors in mice, researchers at Dana-Farber Cancer Institute have shown, validating a controversial theory about cancer causation put forth by a scientific visionary nearly 100 years ago.

12 Oct 2005

Protein called CPSF73 performs a necessary step in the production of human chromosomes

The study found that a protein called CPSF73 acts like scissors to cut strands of histone messenger RNA (mRNA) in the cell nucleus. This cutting action produces the mRNA needed to create histone proteins that combine with DNA to form chromosomes.

12 Oct 2005

New treatments for health conditions related to abnormal iron metabolism

A new study conducted by scientists at Children's Hospital Oakland Research Institute could help researchers develop new treatments for a variety of health conditions that are all related to abnormal iron metabolism. More than one million Americans have abnormal iron levels in their bodies.

10 Oct 2005

Cells have developed a surprising transportation system for their endosomes

...according to research published today in Physical Review Letters, "Dynamics and Spatial Organization of Endosomes in Mammalian Cells."

5 Oct 2005

First recordings from medial mammillary body cells in awake animals

It's often said that the key to Bill Bradley's basketball success was summed up in the title of the 1965 book by John McPhee, "A sense of where you are." Bradley always seemed to know where all nine other players were, where Bradley himself was in relation to the basket – and where the open spot was to be found for his stylized jump shot.

4 Oct 2005

Greasing the gears that drive the interferon signal

Interferon -- a critical protein that mediates the body's defense against a wide variety of infectious agents and tumors -- may soon have greater therapeutic value as the result of a new study by researchers at Washington University School of Medicine in St. Louis.

3 Oct 2005

New Stat1 and interferon findings

By altering a molecule called Stat1, which is involved in cellular immune signaling, scientists have succeeded in making the molecule more responsive and thus more efficient. This old protein with a new twist may eventually be used to improve the body's defense against infection.

28 Sep 2005

Possibility of tailored treatments for addiction based on how a person's genes behave

Scientists have learned how a genetic variation long suspected in making some people susceptible to alcoholism and narcotic drug addiction actually does so.

27 Sep 2005

Pursuit of potential drugs and small molecules that target the IGF-1 receptor

Pharmaceutical companies around the world still come knocking on Renato Baserga, M.D.,'s door. And for good reason.

27 Sep 2005

New method to measure circadian cycles

Everyone knows morning people and late-night owls. The variation in individual circadian rhythms is an anecdotal as well as experimentally verified fact. But, until now, to systematically study circadian differences (and thereby hope to rout out the underlying genetic causes), scientists have had to rely on prolonged behavioural observation.

27 Sep 2005